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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 15 hits in this display   

TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  52nMAssay Description:Inhibition of human MLK3 using myelin basic protein as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  53nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  57nMAssay Description:Inhibition of human BLK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  87nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 4(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  92nMAssay Description:Inhibition of human RIPK4 using histone H2A as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  168nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  179nMAssay Description:Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  186nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  240nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  356nMAssay Description:Inhibition of human TAK1 using casein as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  398nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  794nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells after 2 hrs by Cy3b-Dofetilide-based fluorescence polarisation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibition of human recombinant Flag-6His-Thr-tagged Aurora B assessed as phosphorylation of 5FAM-PKA-tide substrate after 150 mins by fuorescence po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50419254(CHEMBL1835063)
Affinity DataIC50:  9.13E+3nMAssay Description:Inhibition of human CK2a using RRRDDDSDDD as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed