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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetCarbonic anhydrase 7(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human CA7 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  45nMAssay Description:Inhibition of recombinant human CA12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  58nMAssay Description:Inhibition of recombinant human CA2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 6(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  98nMAssay Description:Inhibition of recombinant human CA6 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  126nMAssay Description:Inhibition of recombinant human CA9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  172nMAssay Description:Inhibition of recombinant human CA13 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  677nMAssay Description:Inhibition of recombinant human CA14 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  922nMAssay Description:Inhibition of recombinant human CA1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  939nMAssay Description:Inhibition of recombinant human CA4 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibition of recombinant human CA5a preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5B, mitochondrial(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi:  5.33E+3nMAssay Description:Inhibition of recombinant human CA5b preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 3(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human CA3 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPOU domain, class 5, transcription factor 1(Homo sapiens (Human))
Shin Nippon Biomedical Laboratories

US Patent
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50:  6.76E+4nMAssay Description:An existing amount of the OCT3 protein can be estimated from an amount of a compound free in the extracellular fluid in a method similar to a method ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50103514(CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed