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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
30
hits in this display
Target
Hrh3 protein
(RAT)
U. 109
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
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Affinity Data
Ki: 0.100nM
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Target
Hrh3 protein
(RAT)
U. 109
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.100nM
More data for this Ligand-Target Pair
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Target
Hrh3 protein
(RAT)
U. 109
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
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Affinity Data
Ki: 0.150nM
More data for this Ligand-Target Pair
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Target
Hrh3 protein
(RAT)
U. 109
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
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Affinity Data
Ki: 0.300nM
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.570nM
Assay Description:
Displacement of [3H[N-alpha-methylhistamine form human recombinant histamine H3 receptor expressed in CHO cells after 1 hr by liquid scintillation co...
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.600nM
More data for this Ligand-Target Pair
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.700nM
Assay Description:
Displacement of [125I]iodoproxyfan from human full-length histamine H3 receptor expressed in HEK293 cells after 60 mins
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Target
Hrh3 protein
(RAT)
U. 109
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.58nM
Assay Description:
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation counting
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.58nM
Assay Description:
Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting
More data for this Ligand-Target Pair
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.60nM
Assay Description:
Displacement of [3H]histamine from human full-length histamine H4 receptor expressed in HEK293 cells after 60 mins
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3D Structure (crystal)
Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.62nM
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2nM
Assay Description:
Ligand displacement assays were performed on The SK-N-MC/hH3R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...
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Target
Histamine H3 receptor
(Mus musculus)
Tsukuba Research Institute
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
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Affinity Data
Ki: 2nM
Assay Description:
Displacement of 3-([1,1,1-3H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-4(3H)-quinazolinone from mouse histamine H3 receptor expressed in HE...
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
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Affinity Data
Ki: 2.70nM
More data for this Ligand-Target Pair
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.60nM
Assay Description:
Displacement of [3H]histamine from human histamine H4 receptor expressed in SK-NM-C cells
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6nM
Assay Description:
Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.31nM
Assay Description:
Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.31nM
Assay Description:
Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting
More data for this Ligand-Target Pair
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.80E+3nM
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+4nM
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Target
Histamine H3 receptor
(GUINEA PIG)
TBA
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
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Affinity Data
IC50: 4.60nM
Assay Description:
Histamine H3 receptor agonist activity was assessed by the inhibition of the electrically evoked twitch response of the guinea-pig ileum.
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Freie UniversitäT Berlin
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
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Affinity Data
EC50: 1nM
Assay Description:
In vitro intrinsic activity against histamine H3 receptor from synaptosomes of rat cerebral cortex
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 51nM
Assay Description:
Inhibition of human Histamine H4 receptor
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Target
Histamine H4 receptor
(Homo sapiens (Human))
Jagiellonian University Medical College
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 12.6nM
Assay Description:
Agonist activity at human histamine H4 receptor
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 2.40nM
Assay Description:
Agonist activity at human recombinant histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 1 hr by liquid scintillat...
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Target
Histamine H3 receptor
(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute
Curated by
PDSP K
i
Database
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.90nM
Assay Description:
Inhibition of human Histamine H3 receptor using [3H]-N-alpha-methyl histamine
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Freie UniversitäT Berlin
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
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Affinity Data
EC50: 1nM
Assay Description:
The compound was evaluated for agonistic effect on release of [3H]-histamine from rat brain cortical slices with L-[3H]-histidine at 0.3 microM
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Freie UniversitäT Berlin
Curated by
ChEMBL
Ligand
BDBM22911
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Copy SMILES
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Affinity Data
EC50: 2.80nM
Assay Description:
In vitro binding affinity against histamine H3 receptor from synaptosomes of rat cerebral cortex
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