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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  16nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  20nMAssay Description:The compound was tested for inhibition of human urokinase type plasminogen activator (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  20nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  190nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  350nMAssay Description:The compound was tested for inhibition of human plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  350nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  660nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  750nMAssay Description:The compound was tested for inhibition of human coagulation factor VIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  980nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1/Trypsin-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  1.10E+3nMAssay Description:The compound was tested for inhibition of human trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  1.10E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  1.30E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity against human coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  1.60E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  3.60E+3nMAssay Description:The compound was tested for inhibition of human tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  3.60E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  6.30E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

LigandPNGBDBM14150(APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-...)
Affinity DataKi:  7.50E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

LigandPNGBDBM50106239(6-Fluoro-2-(2-hydroxy-biphenyl-3-yl)-1H-indole-5-c...)
Affinity DataKi:  7.50E+3nMAssay Description:The compound was tested for inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed