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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human cathepsin S by ADAM-28 substrate-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as invariant chain-li degradationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50314218((S)-2-(3-(3-(2-(4-fluoropiperidin-1-yl)ethylthio)-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of cathepsin S in human JY cells assessed as accumulation of invariant chain p10 fragment after 24 hrs by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed