Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  100nMAssay Description:Inhibition of SCD1 in rat liver microsomes assessed as formation of oleoyl-CoA from 9,10-3H-steroyl-CoAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  100nMAssay Description:Inhibition of rat SCD by rat microsomal assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA desaturase 1(Rattus norvegicus (Rat))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  106nMAssay Description:Inhibition of SCD1 in Wistar rat liver microsome assessed as [3H]stearoyl-CoA to [3H]oleoyl-CoA conversion pretreated 1 hr before [3H]stearoyl-CoA ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  254nMAssay Description:Inhibition of SCD1 in human HepG2 cells assessed as [14C]stearic acid to [14C]oleic acid conversion pretreated 15 mins before [14C]stearic acid addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50:  300nMAssay Description:Inhibition of SCD1 in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA 6-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to delta-6 saturase in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50301057(2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)th...)
Affinity DataIC50: >5.00E+4nMAssay Description:Binding affinity to delta-5 saturase in human HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed