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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Metallo-beta-lactamase type 2
(Klebsiella pneumoniae)
Merck Sharp & Dohme
US Patent
Ligand
BDBM530908
((R)-N1-(3-amino- 2-hydroxypropyl)- 4-(4-(3- hydrox...)
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Affinity Data
IC50: 3.07nM
Assay Description:
The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Beta-lactamase
(Pseudomonas aeruginosa)
Merck Sharp & Dohme
US Patent
Ligand
BDBM530908
((R)-N1-(3-amino- 2-hydroxypropyl)- 4-(4-(3- hydrox...)
Copy SMILES
Affinity Data
IC50: 3.56nM
Assay Description:
The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
VIM-1 metallo-beta-lactamase
(Klebsiella pneumoniae)
Merck Sharp & Dohme
US Patent
Ligand
BDBM530908
((R)-N1-(3-amino- 2-hydroxypropyl)- 4-(4-(3- hydrox...)
Copy SMILES
Affinity Data
IC50: 5.87nM
Assay Description:
The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Metallo-beta-lactamase VIM-2
(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme
US Patent
Ligand
BDBM530908
((R)-N1-(3-amino- 2-hydroxypropyl)- 4-(4-(3- hydrox...)
Copy SMILES
Affinity Data
IC50: 7.36nM
Assay Description:
The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI