Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  2.08E+4nMAssay Description:Inhibition of human recombinant renin by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataEC50:  90nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed