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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50:  265nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing APP695 assessed as sAPPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50:  5.10E+3nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of BACE1 (unknown origin) using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon Green]KK-OH as substrate after 3 hrs by fluorescence polarization ass...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142391(US8933221, 1)
Affinity DataIC50:  6.70E+3nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Diseas...More data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Eurofarma Laboratorios

Curated by ChEMBL
LigandPNGBDBM142369(US8933221, 10)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CatD (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed