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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300732((8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300725(8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethox...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300730((8S)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300732((8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300725(8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethox...)
Affinity DataIC50:  1.67E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300732((8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  3.62E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300725(8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethox...)
Affinity DataIC50:  7.87E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300730((8S)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataEC50:  2.56E+3nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300732((8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataEC50:  80nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300725(8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethox...)
Affinity DataEC50:  190nMAssay Description:Inhibition of BACE1 expressed in CHO cells co-expressing human wild type APP protein by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed