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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-secretase 2(Rattus norvegicus)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50428340(CHEMBL2331712)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE2 in rat INS-1E cells assessed as TMEM27 cleavage preincubated for 2 hrs followed by doxycycline addition measured after 46 hrs by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Rattus norvegicus)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50428340(CHEMBL2331712)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Rattus norvegicus)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50428339(CHEMBL2331714)
Affinity DataIC50:  11nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50428339(CHEMBL2331714)
Affinity DataIC50:  12nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP695 assessed as decrease in amyloid beta 40 level after 18 to 20 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50428340(CHEMBL2331712)
Affinity DataIC50:  26nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APP695 assessed as inhibition of amyloid beta (1 to 40) production after 18 to 20 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50428340(CHEMBL2331712)
Affinity DataIC50:  26nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP695 assessed as decrease in amyloid beta 40 level after 18 to 20 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed