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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
22
hits in this display
Target
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor
(Homo sapiens (Human))
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
Ki: 12nM
Assay Description:
Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
Ki: 35nM
Assay Description:
Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligand
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
Ki: 80nM
Assay Description:
Displacement of [3H]clonidine from adrenergic alpha 2 receptor of rat cerebral cortical membranes
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
Ki: 650nM
Assay Description:
Binding affinity against alpha-1 adrenergic receptor in rat using [3H]prazosin as radioligand
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranes
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.50E+3nM
Assay Description:
Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101
More data for this Ligand-Target Pair
Target Info
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Target
Beta-1 adrenergic receptor
(GUINEA PIG)
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
Ki: >3.00E+3nM
Assay Description:
Binding affinity against beta-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of Dihydro-[3H]-alprenolol
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Target
Beta-2 adrenergic receptor
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50087513
((R)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,...)
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Affinity Data
Ki: 1.58E+4nM
Assay Description:
Displacement of [3H]prazosin from human adrenergic beta2 receptor expressed in CHO cell membrane
More data for this Ligand-Target Pair
Target Info
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50087513
((R)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,...)
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Affinity Data
Ki: 2.40E+4nM
Assay Description:
Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes
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Target
Beta-2 adrenergic receptor
(Canis familiaris)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50087513
((R)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,...)
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Affinity Data
Ki: 2.80E+4nM
Assay Description:
Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes
More data for this Ligand-Target Pair
Target Info
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Target
Beta-2 adrenergic receptor
(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Copy InChI
Affinity Data
Ki: 2.90E+4nM
Assay Description:
Binding affinity against adrenergic beta 2 receptor versus 1 nM [3H]dihydroalprenolol in rat cerebral cerebellar membranes
More data for this Ligand-Target Pair
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.50E+4nM
Assay Description:
Displacement of [3H]dihydroalprenolol from adrenergic beta 1 receptor of rat cerebral cortical membranes
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Beta-2 adrenergic receptor
(Canis familiaris)
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.80E+4nM
Assay Description:
Binding of [3H]-dihydroalprenolol to beta-2 adrenergic receptor of rat cerebral cortical membranes
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.30E+4nM
Assay Description:
Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by
ChEMBL
Ligand
BDBM50087513
((R)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,...)
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Affinity Data
Ki: 1.34E+5nM
Assay Description:
Displacement of [3H]prazosin from human adrenergic Alpha-1B receptor expressed in CHO cell membrane
More data for this Ligand-Target Pair
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Target
Beta-1/Beta-2/Beta-3 adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Affinity Data
EC50: >1.00E+5nM
Assay Description:
Agonist activity at beta-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectros...
More data for this Ligand-Target Pair
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Target
Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
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Copy InChI
Affinity Data
EC50: 3.00E+3nM
Assay Description:
Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membrane
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(Rattus norvegicus (rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 5.00E+3nM
Assay Description:
Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Beta-1 adrenergic receptor
(GUINEA PIG)
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 3.60E+4nM
Assay Description:
Beta-1 adrenergic receptor agonist activity by stimulation of contraction rate of isolated guinea pig atrial preparations
More data for this Ligand-Target Pair
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Target
Beta-1/Beta-2/Beta-3 adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: >1.00E+5nM
Assay Description:
Displacement of [3H]dihydroalprenolol from beta-adrenergic receptor in Sprague-Dawley rat cerebral cortical membrane
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
National Institute Of Diabetes
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.25E+5nM
Assay Description:
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...
More data for this Ligand-Target Pair
Target Info
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Target
Beta-1/Beta-2/Beta-3 adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
ChEMBL
Ligand
BDBM50019061
((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: >1.00E+4nM
Assay Description:
Stimulation of cyclic AMP accumulation in C6 glioma cells expressing adrenergic beta receptor
More data for this Ligand-Target Pair
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