Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 2 hits in this display   

TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

LigandBDBM432484(N-(1-((2-aminoethyl)sulfonyl)piperidin-4- yl)-5-cy...)Copy SMILESCopy InChI

Affinity DataIC50:  398nMAssay Description:Inhibition of recombinant N-terminal FLAG/His-tagged SMYD3 (unknown origin) expressed in baculovirus infected insect cells using 3H-SAM as substrate ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI

TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL

LigandBDBM432484(N-(1-((2-aminoethyl)sulfonyl)piperidin-4- yl)-5-cy...)Copy SMILESCopy InChI

Affinity DataIC50:  1.42E+3nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails US PatentPDB3D Structure (crystal)
Copy BDB DOI