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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
25
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Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 34nM
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Target
Norepinephrine transporter
(RAT)
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 72.5nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 106nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 1.56E+3nM
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 5.90E+3nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: >1.70E+4nM
Assay Description:
Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptor
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
TBA
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 2.30E+4nM
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Target
D(4) dopamine receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: >3.50E+4nM
Assay Description:
Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptor
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 1.60E+5nM
Assay Description:
Affinity towards Dopamine receptor D2
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Target
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine))
University Of Kansas
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 2.94E+5nM
Assay Description:
The compound was tested for In vitro inhibitory activity against Phenylethanolamine N-Methyltransferase (PNMT)
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
University Of Texas At Austin
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Ki: 3.90E+5nM
Assay Description:
Affinity towards Dopamine receptor D1
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Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
Copy InChI
Affinity Data
IC50: 882nM
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Target
Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
IC50: >2.99E+4nM
More data for this Ligand-Target Pair
Target Info
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Target
Guanine nucleotide-binding protein subunit alpha-15
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
Copy InChI
Affinity Data
EC50: >2.99E+4nM
More data for this Ligand-Target Pair
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Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
EC50: 731nM
Assay Description:
Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...
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Target
Beta-secretase 1
(Homo sapiens (Human))
F. Hoffmann-La Roche
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
Kd: 2.00E+6nM
Assay Description:
Binding affinity to BACE1 by surface plasmon resonance method
More data for this Ligand-Target Pair
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3D Structure (crystal)
Copy BDB DOI
Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
Copy InChI
Affinity Data
EC50: 178nM
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Howard Hughes Medical Institute
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
EC50: 2.60E+4nM
Assay Description:
Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay
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Target
Trace amine-associated receptor 1
(Mus musculus (Mouse))
University Of Copenhagen
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
EC50: 280nM
Assay Description:
Agonist activity at mouse TAAR1 stably expressed in HEK293 cells incubated for 30 mins by cAMP assay
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
EC50: 69nM
Assay Description:
Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr
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Target
TyR1
(Chilo suppressalis)
Zhejiang University
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
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Affinity Data
EC50: 369nM
Assay Description:
Agonist activity at Chilo suppressalis (rice stem borer) tyramine receptor TyR1 expressed in HEK293 cells assessed as reduction in forskolin-induced ...
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Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
Copy InChI
Affinity Data
EC50: 76nM
Assay Description:
Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analys...
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Target
Trace amine-associated receptor 1
(Homo sapiens (Human))
Synaptic Pharmaceutical
Curated by
PDSP K
i
Database
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
Copy InChI
Affinity Data
EC50: 990nM
Assay Description:
Agonist activity at human TAAR1 stably expressed in HEK293 cells incubated for 30 mins by cAMP assay
More data for this Ligand-Target Pair
Target Info
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Target
Trace amine-associated receptor 1
(Rattus norvegicus (Rat))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
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Affinity Data
EC50: 30nM
Assay Description:
Agonist activity at rat TAAR1 stably expressed in HEK293 cells incubated for 30 mins by cAMP assay
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 2B
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Copy SMILES
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Affinity Data
Kd: 7.94E+3nM
Assay Description:
Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor
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