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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
49
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Target
Carbonic anhydrase 14
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 52nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 62nM ΔG°: -41.1kJ/mole
pH: 7.4 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 65nM ΔG°: -41.0kJ/mole
pH: 7.4 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 6
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 245nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 261nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 5B, mitochondrial
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 322nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 420nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 5A, mitochondrial
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 499nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 7
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 513nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 13
(Mus musculus (mouse))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 550nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
Carbonic anhydrase 4
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 564nM
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Target
CDGSH iron-sulfur domain-containing protein 1
(Homo sapiens (Human))
West Virginia University
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 2.29E+3nM
Assay Description:
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...
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Target
G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 3.27E+3nM
Assay Description:
Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis
Checked by Author
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Target
Solute carrier family 22 member 6
(Rattus norvegicus)
Kyoto University Hospital
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 9.50E+3nM
Assay Description:
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
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Target
Solute carrier organic anion transporter family member 2A1
(Rattus norvegicus (Rat))
Albert Einstein College Of Medicine
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 4.70E+4nM
Assay Description:
TP_TRANSPORTER: inhibition of PGF2alpha uptake in PGT-expressing HeLa cells
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 6.20E+4nM ΔG°: -24.0kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 6.50E+4nM ΔG°: -23.9kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...
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Target
Adenosine receptor A2a/A2b
(Rattus norvegicus)
Kyowa Hakko Kogyo
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 5...
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Target
Adenosine receptor A1
(GUINEA PIG)
Kyowa Hakko Kogyo
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand
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Target
6-phosphogluconate dehydrogenase, decarboxylating
(Homo sapiens (Human))
Ataturk University
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 1.27E+5nM IC50: 1.25E+5nM
Assay Description:
In order to determine the effects of some drugs on human 6PGD, concentrations of ketotifen (0.0018-0.0282 mM), dacarbazine (0.0049-0.054 mM), meloxic...
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Target
Albumin
(Homo sapiens (Human))
Molecular Discovery
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 1.38E+5nM
Assay Description:
Binding affinity towards human serum albumin
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Target
Glucose-6-phosphate 1-dehydrogenase
(Homo sapiens (Human))
Ataturk University
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 1.87E+5nM IC50: 3.15E+5nM
Assay Description:
Ketotifen, dacarbazine, thiocolchicoside, meloxicam, methotrexate, furosemide, olanzapine, methylprednizolone acetate, paricalcitol, ritodrine hydroc...
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Target
Carbonic anhydrase 3
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: >2.00E+5nM ΔG°: >-21.1kJ/mole
pH: 7.4 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...
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Carbonic anhydrase 12
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 2.61E+5nM ΔG°: -20.5kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...
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Carbonic anhydrase 9
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 4.20E+5nM ΔG°: -19.3kJ/mole
pH: 7.5 T: 2°C
Assay Description:
An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...
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Target
Serum paraoxonase/arylesterase 1
(Homo sapiens (Human))
AtatÜRk University
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Ki: 7.02E+5nM IC50: 3.60E+5nM
Assay Description:
The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...
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Carbonic anhydrase 1
(Homo sapiens (Human))
Universita Degli Studi Di Firenze
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 80nM
Assay Description:
Compounds which are CAIs are well known in the art, see for example, Pastorekova et al, Journal of Enzyme Inhibition and Medicinal Chemistry, 19(3), ...
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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
(Homo sapiens (Human))
Federal University Of Parana
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 3.20E+3nM
Assay Description:
Inhibition of ABCG2 (unknown origin) expressed in human HEK293-A cells membrane vesicles assessed inhibition of ABCG2-mediated urate transport activi...
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse))
Institute Of Materia Medica
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 3.76E+3nM
Assay Description:
Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...
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Target
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human))
Institute Of Materia Medica
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 3.76E+3nM
Assay Description:
Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay in...
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Target
Aquaporin-4
(Rattus norvegicus)
TBA
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 1.00E+4nM
Assay Description:
Inhibition of rat AQP4 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 to ...
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Holo-[acyl-carrier-protein] synthase
(Bacillus subtilis)
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 1.27E+4nM
Assay Description:
Inhibitory activity against Bacillus subtilis AcpS by HTRF assay
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Sodium/bile acid cotransporter
(Homo sapiens (Human))
Vanderbilt University School Of Medicine
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 1.50E+4nM
Assay Description:
TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
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Target
Cytochrome P450 2J2
(Homo sapiens (Human))
Tongji University
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method
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CDGSH iron-sulfur domain-containing protein 1
(Homo sapiens (Human))
West Virginia University
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 5.35E+4nM
Assay Description:
Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...
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Target
CDGSH iron-sulfur domain-containing protein 1
(Homo sapiens (Human))
West Virginia University
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: 1.02E+5nM
Assay Description:
Binding affinity to mitoNEET (unknown origin) by fluorescence based assay
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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Target
ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >5.00E+5nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >9.65E+5nM
Assay Description:
Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Ability to inhibit the binding of [125I]RT155 to hNET in HEK cells
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Bile salt export pump
(Rattus norvegicus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...
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Target
Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
IC50: >1.00E+6nM
Assay Description:
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
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CDGSH iron-sulfur domain-containing protein 1
(Homo sapiens (Human))
West Virginia University
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
Kd: 5.30E+4nM
Assay Description:
Binding affinity to mitoNEET (unknown origin) by SPR method
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G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
EC50: 1.12E+4nM
Assay Description:
Agonist activity at C-terminal beta-galactosidase tagged human recombinant GPR35 expressed in CHO cells after 90 mins by beta-arrestin recruitment as...
Checked by Author
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G-protein coupled receptor 35
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM25902
(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
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Affinity Data
EC50: 6.20E+3nM
Assay Description:
Agonist activity at human GPR35 by Ca+2 release assay
Checked by Author
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