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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetCarbonic anhydrase 12(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  31nMAssay Description:Inhibitiory activity against human Carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 5A, mitochondrial(Mus musculus (mouse))
Universita Degli Studi Di Firenze

LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  74nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  112nMAssay Description:Inhibitiory activity against human Carbonic anhydrase IX (hCA IX)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  133nMAssay Description:Inhibitiory activity against human Carbonic anhydrase II (hCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  133nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi Di Firenze

LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  2.10E+3nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  1.46E+4nMAssay Description:Inhibitiory activity against human Carbonic anhydrase I (hCA I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16644(2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetamide | 4...)
Affinity DataKi:  1.46E+4nM ΔG°:  -27.6kJ/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed