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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display   

TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  80nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant HDAC3 (unknown origin) at 15 uM measured after 60 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  80nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorometric substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  190nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues)/N-terminal GST-tagged recombinant human NCoR2 (395 to 489 residues) c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3/NCOR2 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: <1.00E+3nMAssay Description:The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Boc-Lys(Ac)-AMC as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: <1.00E+3nMAssay Description:The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  3.00E+3nMAssay Description:The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  3.00E+3nMAssay Description:The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  3.00E+3nMAssay Description:The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  3.00E+3nMAssay Description:The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant C-terminal His/FLAG-tagged HDAC1 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC2 using Boc-Lys-(epsilon-Ac)-AMC as fluorogenic substrate incubated for 90 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorometric substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Guizhou Medical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorometric substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorometric substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human recombinant HDAC2 incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50254780(CHEMBL4078477 | US10301323, Compound D2 | US990889...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of human recombinant HDAC1 incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed