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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Prolyl endopeptidase
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
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Affinity Data
Ki: 0.970nM
Assay Description:
Inhibition of prolyl oligopeptidase (unknown origin)
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
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Affinity Data
IC50: 1.30nM
Assay Description:
Inhibition of pig brain POP
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
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Affinity Data
IC50: 2.20nM
Assay Description:
In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pig brain ;value ranges from (1.9-2.5)
More data for this Ligand-Target Pair
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.20nM
Assay Description:
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate
More data for this Ligand-Target Pair
Target Info
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KEGG
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CHEMBL
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.20nM
Assay Description:
Inhibition of pig brain POP
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.20nM
pH: 7.0
Assay Description:
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...
More data for this Ligand-Target Pair
Target Info
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KEGG
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CHEMBL
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Target
Prolyl endopeptidase
(Mus musculus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
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Affinity Data
IC50: 4.70nM
Assay Description:
Inhibition of mouse brain POP
More data for this Ligand-Target Pair
Target Info
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Target
Prolyl endopeptidase
(Rattus norvegicus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
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Affinity Data
IC50: 7.20nM
Assay Description:
Inhibition of rat brain POP
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 12nM
Assay Description:
Inhibition of recombinant porcine brain PREP expressed in Escherichia coli assessed as formation of 7-amido-4-methylcoumarin using Suc-Gly-Pro-amido-...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
Inhibition of Prolyl endopeptidase
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Rattus norvegicus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Inhibition of POP in Sprague-Dawley rat brain homogenates
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Rattus norvegicus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Inhibitory activity against rat brain Prolyl endopeptidase (PEP)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
Copy BDB DOI
Target
Prolyl endopeptidase
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 49nM
Assay Description:
In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Inhibition of pig PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide substrate
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Homo sapiens (Human))
University Of Helsinki
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 190nM
Assay Description:
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from bovine brain
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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CHEMBL
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Bos taurus)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10E+3nM
Assay Description:
Inhibition of bovine brain POP
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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Article
PubMed
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Target
Dipeptidyl peptidase 2
(Homo sapiens (Human))
University Of Antwerp
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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PubMed
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Target
Dipeptidyl peptidase 4
(Homo sapiens (Human))
University Of Antwerp
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase FAP
(Mus musculus (Mouse))
University Of Antwerp
Curated by
ChEMBL
Ligand
BDBM50051539
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mi...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
Copy BDB DOI