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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Procathepsin L
(Homo sapiens (Human))
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 126nM
Assay Description:
Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...
More data for this Ligand-Target Pair
Target Info
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Target
Procathepsin L
(Bos taurus (bovine))
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 180nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
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Target
Procathepsin L
(Homo sapiens (Human))
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 230nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Cathepsin K
(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 260nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: >330nM
pH: 6.0
Assay Description:
Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysis
More data for this Ligand-Target Pair
Target Info
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Target
Papain
(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 360nM ΔG°: -36.8kJ/mole
pH: 6.5 T: 2°C
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...
More data for this Ligand-Target Pair
Target Info
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Target
Cruzipain
(Trypanosoma cruzi)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 501nM
Assay Description:
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...
More data for this Ligand-Target Pair
Target Info
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Target
Cruzipain
(Trypanosoma cruzi)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 501nM
Assay Description:
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-phe-Arg-7-amido-4-methylcoumarin as substrate by fluorometric method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Cruzipain
(Trypanosoma cruzi)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 501nM
Assay Description:
Covalent inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-7-amidomethylcoumarin as substrate measured after 5 mins by fluorometric analysis
More data for this Ligand-Target Pair
Target Info
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Target
Cathepsin S
(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
Ki: 510nM
Assay Description:
Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
IC50: 6.20E+4nM
Assay Description:
Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.
More data for this Ligand-Target Pair
Target Info
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Target
Cathepsin B
(Homo sapiens (Human))
University Of Bonn
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.20E+4nM
Assay Description:
Inhibition of recombinant human cathepsin B expressed in baculovirus expression system using Z-Arg-Arg-AMC as substrate incubated for 20 mins by fluo...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Cysteine protease ATG4B
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assay
More data for this Ligand-Target Pair
Target Info
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Target
Cysteine protease ATG4B
(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by
ChEMBL
Ligand
BDBM20096
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
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Affinity Data
IC50: >2.00E+5nM
Assay Description:
Inhibition of ATG4B (unknown origin) using His-GATE-16-GST as substrate preincubated for 30 mins followed by substrate addition measured after 30 min...
More data for this Ligand-Target Pair
Target Info
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MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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CHEMBL
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