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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM139026(US8884017, 51)
Affinity DataKi:  3.90nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM50173952(Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  14.6nMAssay Description:Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM50173952(Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  14.6nMAssay Description:Binding affinity towards human nicotinic acetylcholine receptor alpha 7 expressed in GH4C1 cell using [3H]methyllycaconitineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Targacept

Curated by ChEMBL
LigandPNGBDBM50173952(Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  49.8nMAssay Description:Inhibition of human 5HT3RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50173952(Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo...)
Affinity DataKi:  49.8nMAssay Description:Binding affinity for human 5-hydroxytryptamine 3 serotonin membrane receptor using [3H]GR-65630More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed