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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetPapain(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  62nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  77nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  126nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Bos taurus (bovine))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  230nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi: >330nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo Avenue Trabalhador Sancarlense

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Covalent inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-7-amidomethylcoumarin as substrate measured after 5 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo Avenue Trabalhador Sancarlense

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of S£O Paulo Avenue Trabalhador Sancarlense

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin K(Homo sapiens (Human))
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  1.50E+3nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product AMC at the wavelengths for excitation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataIC50:  360nMAssay Description:Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed