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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
29
hits in this display
Target
Sentrin-specific protease 6
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 345nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
KEGG
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Target
Sentrin-specific protease 8
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 899nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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Target
Caspase-3
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 1.02E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Target
Caspase-9
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 1.72E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Glycoprotein 42
(Human herpesvirus 4 type 2)
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 1.73E+3nM
Assay Description:
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...
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Target Info
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 2.22E+3nM
Assay Description:
The Cdc25B Phosphatase probe assessment dose response reproducibility assay has been developed to re-confirm actives that were identified in the Cdc2...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 3.28E+3nM
Assay Description:
The Cdc25B Phosphatase HTS dose response confirmation has been developed to confirm actives identified in the Cdc25B HTS AID 368, screened at the Uni...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Apoptotic protease-activating factor 1
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 3.31E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Sentrin-specific protease 8
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >5.00E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Cysteine protease ATG4B
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 9.22E+3nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Dual specificity protein phosphatase 1
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 1.07E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Dual specificity protein phosphatase 6
(Rattus norvegicus)
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 1.26E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment MKP-1 dose response selectivity assay has been developed to test the phosphatase specificity of actives that ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Cathepsin B
(Homo sapiens (Human))
Pcmd
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 1.76E+4nM
pH: 6.8 T: 2°C
Assay Description:
Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Mothers against decapentaplegic homolog 3
(Homo sapiens (Human))
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
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Affinity Data
IC50: 1.96E+4nM
Assay Description:
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: F.M. Hoffmann, University ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Serine/threonine-protein phosphatase
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 3.16E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 4.58E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment dose response assay in Catalase has been developed to assess actives that were identified in the Cdc25B HTS A...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.80E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT has been developed to assess actives that were identified in the Cdc25B HTS ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment dose response assay in 25 mM DTT with Catalase has been developed to assess actives that were identified in t...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment dose response assay in Glutathione (GSH) has been developed to assess actives that were identified in the Cdc...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
M-phase inducer phosphatase 2
(Homo sapiens (Human))
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
The Cdc25B Phosphatase probe assessment dose response assay in Beta-Mercaptoethanol (BME) has been developed to assess actives that were identified i...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Procathepsin L
(Homo sapiens (Human))
Pcmd
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 6.70E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Protein-tyrosine kinase 2-beta
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >6.95E+4nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
More data for this Ligand-Target Pair
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PDB
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Target
Focal adhesion kinase 1
(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >7.00E+4nM
Assay Description:
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Phospholipase A2
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >8.00E+4nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Dual specificity protein phosphatase 6
(Rattus norvegicus)
University of Pittsburgh
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...
More data for this Ligand-Target Pair
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Target
Bcl-2-related protein A1
(Mus musculus (Mouse))
Sanford-Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...
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Target
Apoptotic protease-activating factor 1
(Homo sapiens (Human))
Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Bcl-2-related protein A1
(Mus musculus (Mouse))
Sanford-Burnham Center For Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM34182
(3-anilino-2H-isoquinolin-1-one | 3-anilinoisocarbo...)
Copy SMILES
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Affinity Data
IC50: >1.00E+5nM
pH: 7.0 T: 2°C
Assay Description:
The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...
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