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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Sunshine Lake Pharma
US Patent
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
Ki: 0.5nM
pH: 7.4
Assay Description:
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22° C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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Details
US Patent
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Sunshine Lake Pharma
US Patent
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
IC50: 0.230nM
pH: 7.4
Assay Description:
The synaptosomes (150 μg) prepared from a rat brain were incubated at 37° C. for 15 minutes with 0.1 μCi [3H]5-HT in the absence or presenc...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
GoogleScholar
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PC sid
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US Patent
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
Sunshine Lake Pharma
Curated by
ChEMBL
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
IC50: 0.230nM
Assay Description:
Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins ...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Sunshine Lake Pharma
US Patent
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of 5-HT1a (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
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Article
PubMed
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Sunshine Lake Pharma
Curated by
ChEMBL
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of 5-HT2a (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
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Article
PubMed
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Target
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human))
Sunshine Lake Pharma
Curated by
ChEMBL
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of 5-HT2c (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC sid
In Depth
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Article
PubMed
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Sunshine Lake Pharma
Curated by
ChEMBL
Ligand
BDBM264118
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of 5-HT3 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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