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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50:  44nMT: 2°CAssay Description:Activity was assessed by measuring the human PPAR ligand binding domain with the co-activator protein. Europium labeled anti-GST antibody, streptavid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50: >1.00E+4nMT: 2°CAssay Description:PPAR gamma activity was assessed by using the IRBA in mouse 3T3-L1 cells. This assay measures the ability of test compound to cause an increase in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GAL4 fused PPARalpha-LBD expressed in human HepG2 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GAL4 fused PPARgamma-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Bayer Healthcare Pharmaceuticals

LigandPNGBDBM21753(2-[(1S)-5-(3-phenoxypropoxy)-2,3-dihydro-1H-inden-...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human GAL4 fused PPARdelta-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed