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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50152151(CHEMBL3781006)
Affinity DataIC50:  7nMAssay Description:Inhibition of FLAP in human PMNL cells assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50152151(CHEMBL3781006)
Affinity DataIC50:  7nMAssay Description:Inhibition of FLAP in human monocyte assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated with enzyme for 15 mins fol...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Campania "Luigi Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50152151(CHEMBL3781006)
Affinity DataIC50:  65nMAssay Description:Inhibition of 5-LOX (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))TBA
LigandPNGBDBM50152151(CHEMBL3781006)
Affinity DataIC50:  240nMAssay Description:Inhibition of FLAP in Ca+2 ionophore A23187 stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Campania "Luigi Vanvitelli

Curated by ChEMBL
LigandPNGBDBM50152151(CHEMBL3781006)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of recombinant human 5-LO expressed in Escherichia coli BL21 assessed as 5-LO product formation preincubated for 15 mins followed by addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed