Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 23 hits in this display
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
IC50: 0.330nMAssay Description:Inhibition of MEK1 in mouse colon 26 cells assessed as reduction in ERK1/2 phosphorylation after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
IC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged human BRAF/MEK1/RAF1 Y340D/Y341D double mutant measured after 2 hrs in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
IC50: 13.8nMAssay Description:The IC50 for MEK1 and 2 can be measured by methods in references such as [Yamaguchi et al. (2011) International Journal of Oncology 39:23-31].More data for this Ligand-Target Pair
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
IC50: 25nMAssay Description:Inhibition of inactive ERK2 (unknown origin) coupled with human MEK1 using IMAP peptide substrate after 30 mins by coupled ERK2 assayMore data for this Ligand-Target Pair
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)
BDBM104963(CHEMBL507361 | US11147816, PD0325901 | US11701360,...)