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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
Ki: 0.0600nM
Assay Description:
Inhibition of poricne brain POP in expressed in Escherichia coli TOP10 competent cells pre-incubated for 2 hrs before Z-Gly-Pro-AMC substrate additio...
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
Ki: 0.0600nM
Assay Description:
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate
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Target
Prolyl endopeptidase
(Rattus norvegicus)
Institut De Recherche Servier
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: 0.100nM
Assay Description:
Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat brain
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Target Info
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibition of pig brain POP
More data for this Ligand-Target Pair
Target Info
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KEGG
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Article
PubMed
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Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 0.200nM
Assay Description:
Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Prolyl endopeptidase
(Sus scrofa)
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: 0.200nM
pH: 7.0
Assay Description:
In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...
More data for this Ligand-Target Pair
Target Info
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Article
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Target
Prolyl endopeptidase
(Rattus norvegicus)
Institut De Recherche Servier
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: 0.830nM
Assay Description:
Inhibition of POP in rat brain homogenate
More data for this Ligand-Target Pair
Target Info
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Target
Dipeptidyl peptidase 4
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of DPP4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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Target
Xaa-Pro dipeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of prolidase
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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Target
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of caboxypeptidase P
More data for this Ligand-Target Pair
Target Info
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MMDB
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antibodypedia
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Target
Cytosol aminopeptidase
(Homo sapiens (Human))
Mcgill University
Curated by
ChEMBL
Ligand
BDBM50051495
((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of proline iminopeptidase)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PC cid
PC sid
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In Depth
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Article
PubMed
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