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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetHistone deacetylase 6(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human HDAC6 expressed in HEK293/T17 cells using pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  0.870nMAssay Description:Evaluated for inhibition of Protease after after resynthesis and purificationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  148nMAssay Description:Inhibition of human HDAC1 expressed in HEK293/T17 cells pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  268nMAssay Description:Inhibition of human HDAC2 expressed in HEK293/T17 cells pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  478nMAssay Description:Inhibition of human HDAC8 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  581nMAssay Description:Inhibition of human HDAC3 expressed in HEK293/T17 cells pre-incubated for 10 mins before Ac-GAK(Ac)-AM substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibition of human HDAC7 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  2.91E+3nMAssay Description:Inhibition of recombinant human full length HDAC1 expressed in baculovirus infected Sf9 insect cells using p53 (379 to 382 residues) derived RHKKAc a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  9.13E+3nMAssay Description:Inhibition of human HDAC5 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human HDAC4 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50:  2.97E+4nMAssay Description:Inhibition of human HDAC9 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The George Washington University

Curated by ChEMBL
LigandPNGBDBM50279258(CHEMBL4177129)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human HDAC11 expressed in HEK293/T17 cells pre-incubated for 10 mins before Boc-Lys(TFA)-AM substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed