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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 7 hits in this display   

TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human recombinant HDAC3/GST-tagged NCOR1 DAD (397 to 503 residues) expressed in baculovirus expression system after 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of recombinant human full length C-terminal flag-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells after 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  19nMAssay Description:Inhibition of NAMPT (unknown origin) using NAM as substrate incubated for 5 mins followed by substrate addition measured after 15 mins by fluorometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  33nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant full length human C-terminal His/flag-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells after 30 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  351nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in baculovirus infected Sf9 insect cells after 30 mins by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50286560(CHEMBL4163681)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC4 (612 to end residues) expressed in baculovirus infected Sf9 insect cells after 30 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed