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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 21 hits in this display   

TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  26nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(Ac)-AMC as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  90nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using fluor de lys SIRT1 as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  160nMAssay Description:Inhibition of class 1 HDAC in human HeLa cell nuclear extract using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  160nMAssay Description:Inhibition of HDAC in human HeLa nuclear extracts using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  330nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  330nMAssay Description:Inhibition of human recombinant C-terminal His-tagged HDAC3 (1 to 428 residues)/N-terminal GST-tagged NCOR2 (395 to 489 residus) expressed in baculov...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  480nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  480nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC2 (1 to 488 residues) expressed in Sf9 insect cells using fluor de lys SIRT1 as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  880nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged AChE (Glu32 to Leu614 residues) expressed in CHO cells using acetylthiocholine iodide as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation after 24 hrs by thioflavin-T fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  5.51E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  5.51E+3nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 (604 to 1066 residues) expressed in baculovirus-infected Sf9 cells using Boc Lys(TFA)-AMC as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  7.19E+3nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC5 (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cells using fluorogen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  7.85E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus expression system u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  7.85E+3nMAssay Description:Inhibition of N-terminal GST-tagged and C-terminal His-tagged human HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 cells using Bo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  9.13E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 (518 to end residues) expressed in baculovirus-infected Sf9 cells using Boc Lys(TFA)-AMC as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataIC50:  9.13E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using fluorogenic HDAC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataEC50:  580nMAssay Description:Inhibition of Class 1 HDAC in human Neuro2a cells assessed as increase in acetylated Histone H3 level measured after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50551544(CHEMBL4796066)
Affinity DataEC50:  8.00E+3nMAssay Description:Inhibition of HDAC6 in human Neuro2a cells assessed as increase in alpha-tubulin acetylation measured after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed