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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
35
hits in this display
Target
Carbonic anhydrase 9
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
Ki: 25nM
Assay Description:
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
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Affinity Data
Ki: 45nM
Assay Description:
Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 478nM
Assay Description:
Inhibition of human recombinant CA9 after 6 hrs by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 480nM
Assay Description:
Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 9
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 482nM
Assay Description:
Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
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Affinity Data
Ki: 750nM
Assay Description:
Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assay
More data for this Ligand-Target Pair
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Target
Carbonic anhydrase 12
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
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Affinity Data
Ki: 754nM
Assay Description:
Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
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Target
Zn finger protein
(Nicotiana tabacum)
Università
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
Ki: 754nM
Assay Description:
Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method
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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human))
Dalian University Of Technology
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
Ki: 3.81E+3nM
Assay Description:
Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
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Affinity Data
Ki: 5.84E+4nM
Assay Description:
Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.84E+4nM
Assay Description:
Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.84E+4nM
Assay Description:
Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of human full-length cytosolic CA2 after 6 hrs by stopped flow CO2 hydration assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assay
More data for this Ligand-Target Pair
Target Info
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
University Of Messina
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+5nM
Assay Description:
Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration method
More data for this Ligand-Target Pair
Target Info
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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human))
Dalian University Of Technology
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 2.10E+4nM
Assay Description:
Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...
More data for this Ligand-Target Pair
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Target
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
University Of Toyama
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 2.29E+4nM
Assay Description:
Inhibition human recombinant aldose reductase 1 by spectrophotometric analysis
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Target
Genome polyprotein
(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Umdnj-New Jersey Medical School
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 3.66E+4nM
pH: 7.0 T: 2°C
Assay Description:
Inhibition assay using HCV NS5B.
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Target
Seed linoleate 13S-lipoxygenase-1
(Glycine max (soybean))
Aristotle University Of Thessaloniki
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 4.30E+4nM
Assay Description:
Inhibitory concentration against soybean lipoxygenase upon incubation with sodium linoleate (0.1 mM) at RT
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Target
Acetylcholinesterase
(Homo sapiens (Human))
University Of Monastir
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by s...
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Target
Sorbitol dehydrogenase
(Homo sapiens (Human))
University Of Toyama
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 1.20E+5nM
Assay Description:
Inhibition sorbitol dehydrogenase by spectrophotometric analysis
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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
(Homo sapiens (Human))
Seoul National University
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: >1.23E+5nM
Assay Description:
Inhibitory activity against 5-alpha-reductase type 1 in cell culture system using LNCaP cells (androgen-sensitive human prostatic cancer cell line)
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Acetylcholinesterase
(Electrophorus electricus (Electric eel))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 1.40E+5nM
Assay Description:
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180...
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Target
Xanthine dehydrogenase/oxidase
(Homo sapiens (Human))
Università
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 2.36E+5nM
Assay Description:
Inhibition of xanthine oxidase
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Tyrosinase
(Homo sapiens (Human))
Universidad De Santiago De Compostela
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 4.20E+5nM
Assay Description:
Inhibition of tyrosinase
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Target
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom))
Mazandaran University Of Medical Sciences
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 4.20E+5nM
Assay Description:
Inhibition of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA as substrate preincubated with enzyme for 10 mins follow...
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Target
Dihydroorotate dehydrogenase (fumarate)
(Leishmania major)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: 4.67E+5nM
Assay Description:
Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...
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Target
Cholinesterase
(Equus caballus (Horse))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: >5.00E+5nM
Assay Description:
Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to ...
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Beta-secretase 1
(Homo sapiens (Human))
Kinki University
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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Affinity Data
IC50: >5.00E+5nM
Assay Description:
Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins by fluorescence quenching assay
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Dihydroorotate dehydrogenase (fumarate)
(Leishmania major)
University Of S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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IC50: 5.01E+5nM
Assay Description:
Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...
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Glyceraldehyde-3-phosphate dehydrogenase, glycosomal
(Trypanosoma cruzi)
Universidade De S£O Paulo
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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IC50: 6.17E+5nM
Assay Description:
Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli by spectrophotometry
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Glyceraldehyde-3-phosphate dehydrogenase
(Homo sapiens (Human))
Universidade Federal De Minas Gerais
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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IC50: 6.17E+5nM
Assay Description:
Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50
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Acetylcholinesterase
(Homo sapiens (Human))
University Of Monastir
Curated by
ChEMBL
Ligand
BDBM50174558
(7-hydroxy-2H-1-benzopyran-2-one | 7-hydroxy-2H-chr...)
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IC50: 2.90E+7nM
Assay Description:
Inhibition of AChE by spectrophotometry
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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PubMed
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