Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataKi:  4.30nMAssay Description:Inhibitory activity against wild-type dihydrofolate reductase (S108N DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataKi:  116nMAssay Description:Inhibitory activity against double mutant dihydrofolate reductase (C59R+S108N DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 250nMAssay Description:In vitro antimalarial activity relative to trimethoprim against Plasmodium falciparum Vl/S with quadruple DHFR mutant (N51I/C59R/S108N/I164L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 360nMAssay Description:In vitro antimalarial activity relative to trimethoprim against Plasmodium falciparum TM4/8.2 wtDHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 370nMAssay Description:In vitro antimalarial activity against Plasmodium falciparum K1CB1 double DHFR mutation (C59R/S108N) relative to trimethoprimMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 420nMAssay Description:In vitro antimalarial activity against Plasmodium falciparum Csl-2 triple DHFR mutant (C59R/S108N/I164L) relative to trimethoprimMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataKi:  467nMAssay Description:Inhibitory activity against triple mutant dihydrofolate reductase (C59R S108 NI164L DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataKi:  698nMAssay Description:Inhibitory activity against quadruple mutant dihydrofolate reductase (N51I C59R S108N I164L DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 2.40E+3nMAssay Description:In vitro antimalarial activity against Plasmodium falciparum TM4/8.2 wtDHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro antimalarial activity against Plasmodium falciparum Csl-2 triple DHFR mutant (C59R/S108N/I164L)/More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro antimalarial activity against Plasmodium falciparum Vl/S with quadruple DHFR mutant (N51I/C59R/S108N/I164L) More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
National Center For Genetic Engineering and Biotechnology At Thailand

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50138703BDBM50138703(6-ethyl-5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-d...)
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro antimalarial activity against Plasmodium falciparum K1CB1 double DHFR mutant (C59R/S108N)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed