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Found 696 Enz. Inhib. hit(s) with Target = 'GTPase KRas [1-169,G12C,C118A]/Son of sevenless homolog 1 [564-1049]'
LigandPNGBDBM653019((M)-1-(6- ((1S,8R)-5- methyl-6-(1,5,6- trimethyl-1...)
Affinity DataIC50:  3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652997(1-(6-(3-chloro- 4-(1,6-dimethyl- 1H-indazol-7- yl)...)
Affinity DataIC50:  5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652949((1R,9R)-6-(7- hydroxy-5- quinolinyl)- 10,10-dimeth...)
Affinity DataIC50:  6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653472((M)-(7R)-4-(2-methylphenyl)-7-(4- methyl-1,3-thiaz...)
Affinity DataIC50:  8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652946((P)-(1R,8S)-6- (3-hydroxy-1- naphthalenyl)-4- (2-(...)
Affinity DataIC50:  9nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653301(1-(6-((1R,9R)-5-fluoro- 10,10-dimethyl-6-(5- methy...)
Affinity DataIC50:  10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653277((1R,9R)-10,10-dimethyl- 6-(6-methyl-1H-indazol- 7-...)
Affinity DataIC50:  11nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653165((6R,8R)-2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-...)
Affinity DataIC50:  12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653092((7R)-4-(2-chlorophenyl)-7- (1-methyl-1H-pyrazol-5-...)
Affinity DataIC50:  12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653305((M)-1-(6-((1R,9R)-5- fluoro-6-(3-hydroxy-1- naphth...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653180((1R,9R)-6-(3-hydroxy-1- naphthalenyl)-10,10- dimet...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653162(7,7-dimethyl-2-(2-(2- propenoyl)-2,6- diazaspiro[3...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653336((M)-1-(6-(4-(5-chloro- 1,6-dimethyl-1H- indazol-7-...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653439(4-(2-chloro-5- hydroxyphenyl)-7-(4- methyl-1,3-thi...)
Affinity DataIC50:  14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652855((P)-7,7-dimethyl-4-(5- methyl-1H-indazol-4-yl)- 2-...)
Affinity DataIC50:  14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653233((1S,8R)-6-(5-methyl-1H- indazol-4-yl)-4-(2-(2- pro...)
Affinity DataIC50:  14nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652975((1R,9R)-6-(5- hydroxy-2- methylphenyl)- 10,10-dime...)
Affinity DataIC50:  15nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653113(4-(3-hydroxy-1- naphthalenyl)-7,7-dimethyl- 2-(2-(...)
Affinity DataIC50:  16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653320(4-(5-chloro-6-methyl- 1H-indazol-7-yl)-7,7- dimeth...)
Affinity DataIC50:  16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653371((P)-1-(6-(4-(6-hydroxy-1- naphthalenyl)-3-methyl- ...)
Affinity DataIC50:  17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653015(8-(5-chloro-1,6- dimethyl-1H- indazol-7-yl)-6- ((5...)
Affinity DataIC50:  17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653233((1S,8R)-6-(5-methyl-1H- indazol-4-yl)-4-(2-(2- pro...)
Affinity DataIC50:  17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653126((P)-6,6-dimethyl-4-(5- methyl-1H-indazol-4-yl)-2- ...)
Affinity DataIC50:  17nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653439(4-(2-chloro-5- hydroxyphenyl)-7-(4- methyl-1,3-thi...)
Affinity DataIC50:  18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653012(8-(5-chloro-1,6- dimethyl-1H- indazol-7-yl)-6- (2-...)
Affinity DataIC50:  18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652984(1-(6-(3-chloro- 4-(3-hydroxy-1- naphthalenyl)- 7,7...)
Affinity DataIC50:  18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653230(US20240059703, Example 14-1)
Affinity DataIC50:  18nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653001(1-(5-methyl-1H- indazol-4-yl)-3- (2-(2- propenoyl)...)
Affinity DataIC50:  19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653473((P)-(7S)-4-(2-methylphenyl)-7-(4-methyl- 1,3-thiaz...)
Affinity DataIC50:  19nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653061((1R,9R)-6-(2-chloro-3- fluoro-5- hydroxyphenyl)-10...)
Affinity DataIC50:  20nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652943(1-(6-(4-(6- chloro-5-methyl- 1H-indazol-4- yl)-3,7...)
Affinity DataIC50:  20nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653000(1-(6-(3-chloro- 4-(6-chloro-5- methyl-1H- indazol-...)
Affinity DataIC50:  21nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652972((1R,9R)-6-(2- chloro-5- hydroxyphenyl)- 10,10-dime...)
Affinity DataIC50:  21nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653244((1S,8R)-6-(1,6-dimethyl- 1H-indazol-7-yl)-4-(2- (2...)
Affinity DataIC50:  22nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653000(1-(6-(3-chloro- 4-(6-chloro-5- methyl-1H- indazol-...)
Affinity DataIC50:  23nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653284(1-(6-(4-(5-chloro-1,6- dimethyl-1H-indazol-7- yl)-...)
Affinity DataIC50:  23nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653529((7S)-4-(3-fluoro-2-pyridinyl)-7-(4-methyl- 1,3-thi...)
Affinity DataIC50:  24nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652997(1-(6-(3-chloro- 4-(1,6-dimethyl- 1H-indazol-7- yl)...)
Affinity DataIC50:  24nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653180((1R,9R)-6-(3-hydroxy-1- naphthalenyl)-10,10- dimet...)
Affinity DataIC50:  24nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653429(4-(2,4-difluorophenyl)- 7-(4-methyl-1,3-thiazol- 5...)
Affinity DataIC50:  25nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653279(1-(6-((1R,9R)-5-fluoro- 6-(5-hydroxy-2- methylphen...)
Affinity DataIC50:  25nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653471((7R)-4-(2-methylphenyl)-7-(4-methyl-1,3- thiazol-5...)
Affinity DataIC50:  26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653088(4-(1,6-dimethyl-1H- indazol-7-yl)-6,6-dimethyl- 2-...)
Affinity DataIC50:  26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653030(1-(6-(4-(3-chloro-5- hydroxy-2- methylphenyl)-3,7,...)
Affinity DataIC50:  26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652960(8-(3-hydroxy-1- naphthalenyl)-6- (2-(2- propenoyl)...)
Affinity DataIC50:  26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653220(4-(5-chloro-1H-indazol-4- yl)-7,7-dimethyl-2-(2-(2...)
Affinity DataIC50:  26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653137(4-(3-hydroxy-1- naphthalenyl)-6,6-dimethyl- 2-(2-(...)
Affinity DataIC50:  27nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM652918((P)-1-(6-(3,7,7- trimethyl-4-(5- methyl-1H- indazo...)
Affinity DataIC50:  27nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653162(7,7-dimethyl-2-(2-(2- propenoyl)-2,6- diazaspiro[3...)
Affinity DataIC50:  27nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM653321(4-(5-chloro-1,6- dimethyl-1H-indazol-7- yl)-7,7-di...)
Affinity DataIC50:  28nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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