BDBM747700 US12325697, Compound ALI-2
- Yang, T; Yang, Y; Chen, Y; Tang, M; Shi, M; Tian, Y; Yuan, X; Yang, Z; Chen, L Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI). Eur J Med Chem 250: (2023)
- Tang, L; Gao, XH; Zhao, B; Luo, JR; Shi, XY; Ge, R; Ban, SR; Li, QS Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI). Bioorg Med Chem 28: (2020)
- Ali, A; Lo, MM; Metzger, E; Yin, L; Hartmann, R; Hu, Q; Heim, R; Zimmer, C US Patent US9745282 (2017)
- Ihmaid, S; Ahmed, HEA; Ali, AA; Sherif, YE; Tarazi, HM; Riyadh, SM; Zayed, MF; Abulkhair, HS; Rateb, HS Bioorg Chem 72: 234-247 (2017)
- Rappas, M; Ali, AAE; Bennett, KA; Brown, JD; Bucknell, SJ; Congreve, M; Cooke, RM; Cseke, G; de Graaf, C; Doré, AS; Errey, JC; Jazayeri, A; Marshall, FH; Mason, JS; Mould, R; Patel, JC; Tehan, BG; Weir, M; Christopher, JA J Med Chem 63: 1528-1543 (2020)
- Ali AH
- Ali AR
- Maghraby, MT; Abou-Ghadir, OMF; Abdel-Moty, SG; Ali, AY; Salem, OIA Bioorg Med Chem 28: (2020)
- Kumar, JA; Tiwari, AK; Ali, AZ; Madhusudhana, K; Reddy, BS; Ramakrishna, S; China Raju, B J Enzyme Inhib Med Chem 25: 80-6 (2010)
- Salar, U; Khan, KM; Taha, M; Ismail, NH; Ali, B; Qurat-Ul-Ain, na; Perveen, S; Ghufran, M; Wadood, A Eur J Med Chem 125: 1289-1299 (2017)
- Abdel-Maksoud, MS; Ali, EMH; Ammar, UM; Mersal, KI; Yoo, KH; Oh, CH Bioorg Med Chem 28: (2020)
- Ali, F; Khan, KM; Salar, U; Iqbal, S; Taha, M; Ismail, NH; Perveen, S; Wadood, A; Ghufran, M; Ali, B Bioorg Med Chem 24: 3624-35 (2016)
- Huffman, WF; Ali, FE; Bryan, WM; Callahan, JF; Moore, ML; Silvestri, JS; Yim, NC; Kinter, LB; McDonald, JE; Ashton-Shue, D J Med Chem 28: 1759-60 (1986)
- Elwaie, TA; Abbas, SE; Aly, EI; George, RF; Ali, H; Kraiouchkine, N; Abdelwahed, KS; Fandy, TE; El Sayed, KA; Abd Elmageed, ZY; Ali, HI J Med Chem 63: 15906-15945 (2020)
- Temirak, A; Shaker, YM; Ragab, FA; Ali, MM; Ali, HI; El Diwani, HI Eur J Med Chem 87: 868-80 (2014)
- Lee, K; Choi, G; Ali, I; Lee, JY; Lee, JS; Park, WJ; Kim, YT; Kim, SH; Kim, JH; Lim, J US Patent US11028090 (2021)
- Ali IH
- Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR J Med Chem 55: 8859-78 (2012)
- Evans, CA; Liu, T; Lescarbeau, A; Nair, SJ; Grenier, L; Pradeilles, JA; Glenadel, Q; Tibbitts, T; Rowley, AM; DiNitto, JP; Brophy, EE; O'Hearn, EL; Ali, JA; Winkler, DG; Goldstein, SI; O'Hearn, P; Martin, CM; Hoyt, JG; Soglia, JR; Cheung, C; Pink, MM; Proctor, JL; Palombella, VJ; Tremblay, MR; Castro, AC ACS Med Chem Lett 7: 862-7 (2016)
- Molinari, AJ; Trybulski, EJ; Bagli, J; Croce, S; Considine, J; Qi, J; Ali, K; Demaio, W; Lihotz, L; Cochran, D Bioorg Med Chem Lett 17: 5796-800 (2007)
- Ali KH
- Taha, M; Rashid, U; Imran, S; Ali, M Bioorg Med Chem 26: 3654-3663 (2018)
- Sivakumar, S; Ranjith Kumar, R; Ali, MA; Choon, TS Eur J Med Chem 65: 240-8 (2013)
- Galal, SA; Khairat, SHM; Ali, HI; Shouman, SA; Attia, YM; Ali, MM; Mahmoud, AE; Abdel-Halim, AH; Fyiad, AA; Tabll, A; El-Shenawy, R; El Abd, YS; Ramdan, R; El Diwani, HI Eur J Med Chem 144: 859-873 (2018)
- Afzal, O; Akhtar, MS; Kumar, S; Ali, MR; Jaggi, M; Bawa, S Eur J Med Chem 121: 318-330 (2016)
- Bankeu, JJ; Khayala, R; Lenta, BN; Noungoué, DT; Ngouela, SA; Mustafa, SA; Asaad, K; Choudhary, MI; Prigge, ST; Hasanov, R; Nkengfack, AE; Tsamo, E; Ali, MS J Nat Prod 74: 1370-8 (2011)
- Abadi, AH; Lehmann, J; Piazza, GA; Abdel-Halim, M; Ali, MSM International Journal of Medicinal Chemistry 2011: 1-9 (2011)
- Seong, SH; Ali, MY; Kim, HR; Jung, HA; Choi, JS Bioorg Med Chem 25: 3964-3970 (2017)
- Joossens, J; Van der Veken, P; Surpateanu, G; Lambeir, AM; El-Sayed, I; Ali, OM; Augustyns, K; Haemers, A J Med Chem 49: 5785-93 (2006)
- Sultan, S; Choudhary, MI; Khan, SN; Fatima, U; Atif, M; Ali, RA; Rahman, AU; Fatmi, MQ Eur J Med Chem 62: 764-70 (2013)
- D'Angelo, DD; Davis, MG; Ali, S; Dorn, GW J Pharmacol Exp Ther 271: 1034-41 (1994)
- Yates, SL; Phillips, JG; Gregory, R; Pawlowski, GP; Fadnis, L; Khan, MA; Ali, SM; Tedford, CE J Pharmacol Exp Ther 289: 1151-9 (1999)
- Ali SS
- Radwan, MO; Ciftci, HI; Ali, TFS; Koga, R; Tateishi, H; Nakata, A; Ito, A; Yoshida, M; Fujita, M; Otsuka, M Bioorg Med Chem Lett 30: (2020)
- Buckley, BJ; Aboelela, A; Minaei, E; Jiang, LX; Xu, Z; Ali, U; Fildes, K; Cheung, CY; Cook, SM; Johnson, DC; Bachovchin, DA; Cook, GM; Apte, M; Huang, M; Ranson, M; Kelso, MJ J Med Chem 61: 8299-8320 (2018)
- Ali, W; Więcek, M; Łażewska, D; Kurczab, R; Jastrzębska-Więsek, M; Satała, G; Kucwaj-Brysz, K; Lubelska, A; Głuch-Lutwin, M; Mordyl, B; Siwek, A; Nasim, MJ; Partyka, A; Sudoł, S; Latacz, G; Wesołowska, A; Kieć-Kononowicz, K; Handzlik, J Eur J Med Chem 178: 740-751 (2019)
- Abdelall, EKA; Lamie, PF; Ali, WAM Bioorg Med Chem Lett 26: 2893-2899 (2016)
- Haider, S; Alam, MS; Hamid, H; Shafi, S; Dhulap, A; Hussain, F; Alam, P; Umar, S; Pasha, MA; Bano, S; Nazreen, S; Ali, Y; Kharbanda, C Eur J Med Chem 81: 204-17 (2014)
- Muhammad, A; Anis, I; Ali, Z; Awadelkarim, S; Khan, A; Khalid, A; Shah, MR; Galal, M; Khan, IA; Iqbal Choudhary, M Bioorg Med Chem Lett 22: 610-2 (2011)
- Lee, CC; Liu, FL; Chen, CL; Chen, TC; Liu, FC; Ahmed Ali, AA; Chang, DM; Huang, HS Bioorg Med Chem 23: 4522-32 (2015)
- Elagawany, M; Ibrahim, MA; Ali Ahmed, HE; El-Etrawy, ASh; Ghiaty, A; Abdel-Samii, ZK; El-Feky, SA; Bajorath, J Bioorg Med Chem Lett 23: 2007-13 (2013)
- Sajid-Ur-Rehman, na; Saeed, A; Saddique, G; Ali Channar, P; Ali Larik, F; Abbas, Q; Hassan, M; Raza, H; Fattah, TA; Seo, SY Bioorg Med Chem 26: 3707-3715 (2018)
- Al-Sanea, MM; Elkamhawy, A; Paik, S; Lee, K; El Kerdawy, AM; Syed Nasir Abbas, B; Joo Roh, E; Eldehna, WM; Elshemy, HAH; Bakr, RB; Ali Farahat, I; Alzarea, AI; Alzarea, SI; Alharbi, KS; Abdelgawad, MA Bioorg Med Chem 28: (2020)
- Saraswati, AP; Ali Hussaini, SM; Krishna, NH; Babu, BN; Kamal, A Eur J Med Chem 144: 843-858 (2018)
- Sajid-Ur-Rehman, na; Saeed, A; Saddique, G; Ali Channar, P; Ali Larik, F; Abbas, Q; Hassan, M; Raza, H; Fattah, TA; Seo, SY Bioorg Med Chem 26: 3707-3715 (2018)
- Mahmood, A; Ali Shah, SJ; Iqbal, J Eur J Med Chem 231: (2022)
- Ali Shah SW
- Thur, Y; Bhalerao, A; Munshi, Z; Pansare, N; Mann, K; Hanauer, G; Kley, HP; Nappe, S; Weiss-Haljiti, C; Ostermann, C; Zitt, C; Schaefer, M; Mondal, D; Ali Siddiki, A; Armugam, V; Gudaghe, V; Gupta, M; Rayudu, P; Dautzenberg, FM; Das Sarma, K Bioorg Med Chem Lett 22: 7314-21 (2012)
- Daskalakis, N; Guttke, CD; Kwon, MC; Ferrante, LA; Packman, KE; Pietsch, EC; Philippar, U; Verhulst, TA; Ali-Ahmed, S; Bhogal, B; Sun, Y; Cai, W; Dai, X; Querolle, OA; Thuring, JW; Liu, Y; Liu, L; Xu, Y; Fu, L; Li, M; Fang, L; Deng, X; Ng, AT; Darville, NF; Pande, V US Patent US20240261292 (2024)
- Bharkavi, C; Vivek Kumar, S; Ashraf Ali, M; Osman, H; Muthusubramanian, S; Perumal, S Bioorg Med Chem 24: 5873-5883 (2016)
- Ayub Ali M
- Elzien Alamin Ali, H; Ozalp, L; Danış, Ö; Odabaş, Z Bioorg Med Chem Lett 74: (2022)
- Çalişkan, B; Luderer, S; Özkan, Y; Werz, O; Banoglu, E Eur J Med Chem 46: 5021-33 (2011)
- ChEMBL_36632 (CHEMBL652343) Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rabbit aortic membrane (AT1 receptor)
- ChEMBL_36768 (CHEMBL650291) Tested for its ability to displace the specific binding ligand [125I]-Sar 1,lle8-AlI from rat midbrain membrane (AT2 receptor)
- In Vitro Measure of Sodium Channel Blocking Activity and Reversibility One assay used to assess mechanism of action and/or potency of the compounds of the present invention involves the determination of lumenal drug inhibition of airway epithelial sodium currents measured under short circuit current (ISC) using airway epithelial monolayers mounted in Using chambers. This assay is described in detail in Hirsh, A. J., Zhang, J., Zamurs, A., et al. Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N′-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for CF lung disease. J. Pharmacol. Exp. Ther. 2008; 325(1): 77-88. Cells obtained from freshly excised human, dog, sheep or rodent airways are seeded onto porous 0.4 micron Snapwell Inserts (CoStar), cultured at air-liquid interface (ALI) conditions in hormonally defined media, and assayed for sodium transport activity (ISC) while bathed in Krebs Bicarbonate Ringer (KBR) in Using chambers. All test drug additions are to the lumenal bath with half-log dose addition protocols (from 1×10−11 M to 3×10−5 M), and the cumulative change in ISC (inhibition) recorded. All drugs are prepared in dimethyl sulfoxide as stock solutions at a concentration of 1×10−2 M and stored at −20° C. Eight preparations are typically run in parallel; two preparations per run incorporate amiloride and/or benzamil as positive controls. After the maximal concentration (5×10−5 M) is administered, the lumenal bath is exchanged three times with fresh drug-free KBR solution, and the resultant ISC measured after each wash for approximately 5 minutes in duration. Reversibility is defined as the percent return to the baseline value for sodium current after the third wash. All data from the voltage clamps are collected via a computer interface and analyzed off-line.Dose-effect relationships for all compounds are considered and analyzed by the Prism 3.0 program. IC50 values, maximal effective concentrations, and reversibility are calculated and compared to amiloride and benzamil as positive controls.