Query String: AnxA6 expression
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- GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes.
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- Su, B; Landini, S; Davis, DD; Brueggemeier, RW Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells. J Med Chem 50: 1635-44 (2007)
- Grinevich, VP; Letchworth, SR; Lindenberger, KA; Menager, J; Mary, V; Sadieva, KA; Buhlman, LM; Bohme, GA; Pradier, L; Benavides, J; Lukas, RJ; Bencherif, M Heterologous expression of human {alpha}6{beta}4{beta}3{alpha}5 nicotinic acetylcholine receptors: binding properties consistent with their natural expression require quaternary subunit assembly including the {alpha}5 subunit. J Pharmacol Exp Ther 312: 619-26 (2005)
- Hayer-Zillgen, M; Brüss, M; Bönisch, H Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol 136: 829-36 (2002)
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- Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers.
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- Warrilow, AG; Melo, N; Martel, CM; Parker, JE; Nes, WD; Kelly, SL; Kelly, DE Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother 54: 4225-34 (2010)
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- Lovenberg, TW; Erlander, MG; Baron, BM; Racke, M; Slone, AL; Siegel, BW; Craft, CM; Burns, JE; Danielson, PE; Sutcliffe, JG Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Proc Natl Acad Sci U S A 90: 2184-8 (1993)
- Inoue, M; Tanabe, H; Nakashima, K; Ishida, Y; Kotani, H Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene. J Nat Prod 77: 1670-7 (2014)
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- Edupuganti, R; Taliaferro, JM; Wang, Q; Xie, X; Cho, EJ; Vidhu, F; Ren, P; Anslyn, EV; Bartholomeusz, C; Dalby, KN Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. Bioorg Med Chem 25: 2609-2616 (2017)
- Lamb, DC; Kelly, DE; Hanley, SZ; Mehmood, Z; Kelly, SL Glyphosate is an inhibitor of plant cytochrome P450: functional expression of Thlaspi arvensae cytochrome P45071B1/reductase fusion protein in Escherichia coli. Biochem Biophys Res Commun 244: 110-4 (1998)
- Wu, Y; Wu, ZR; Chen, P; Yang-Li, na; Deng, WR; Wang, YQ; Li, HY Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorg Med Chem Lett 25: 1476-8 (2015)
- Nikodemova, M; Watters, JJ; Jackson, SJ; Yang, SK; Duncan, ID Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. J Biol Chem 282: 15208-16 (2007)
- Asano, S; Ban, H; Kino, K; Ioriya, K; Muraoka, M Novel 1,4-diarylpiperidine-4-methylureas as anti-hyperlipidemic agents: dual effectors on acyl-CoA:cholesterol O-acyltransferase and low-density lipoprotein receptor expression. Bioorg Med Chem Lett 19: 1062-5 (2009)
- Wilson, KJ; Xiao, J; Chen, CZ; Huang, Z; Agoulnik, IU; Ferrer, M; Southall, N; Hu, X; Zheng, W; Xu, X; Wang, A; Myhr, C; Barnaeva, E; George, ER; Agoulnik, AI; Marugan, JJ Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem 156: 79-92 (2018)
- ChEMBL_2514081 Binding affinity to human ANXA6 incubated for 45 mins by Kinobead based pull down assay
- ChEBML_224214 Inhibition of TNF-alpha-induced VCAM-1 expression
- ChEMBL_305922 (CHEMBL833469) Inhibition of TNFalpha expression in U937 cells
- ChEMBL_312368 (CHEMBL837481) Inhibition of TNFalpha expression in U937 cells
- ChEBML_213807 Ability to inhibit expression of Vascular cell adhesion molecule 1
- ChEMBL_1929414 (CHEMBL4432590) Inhibition of human BRD9 expressed in bacterial expression system
- ChEMBL_1929415 (CHEMBL4432591) Inhibition of human CREBBP expressed in bacterial expression system
- ChEMBL_1929416 (CHEMBL4432592) Inhibition of human EP300 expressed in bacterial expression system
- ChEMBL_2263791 Inhibition of iNOS expression in LPS-induced mouse RAW264.7 cells
- ChEBML_156293 Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression
- ChEBML_213820 Inhibition of TNF-alpha inducible Vascular cell adhesion molecule-1 expression.
- ChEMBL_100745 (CHEMBL710041) Induction of pS2 Gene expression in human MCF-7 cells
- ChEMBL_2028072 (CHEMBL4682230) Binding affinity to human Vps34 expressed in mammalian expression system
- ChEMBL_2270839 Inhibition of human full length PARP1 expressed in baculovirus expression system
- ChEMBL_465171 (CHEMBL945841) Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to red light emiting native luciferase expression
- ChEMBL_100271 (CHEMBL712013) Concentration required to activate luciferase expression in MCF-7-2a cells
- ChEMBL_1282261 (CHEMBL3102610) Inhibition of recombinant IKK2 (unknown origin) expressed in baculovirus expression system
- ChEMBL_156293 (CHEMBL759930) Inhibitory activity against phosphodiesterase 11 (PDE11) obtained from recombinant Sf9 expression
- ChEMBL_1617525 (CHEMBL3859594) Inhibition of recombinant human renin expressed in FreeStyle 293 expression system
- ChEMBL_1929395 (CHEMBL4432571) Inhibition of human TAF1 bromodomain 2 expressed in bacterial expression system
- ChEMBL_1929406 (CHEMBL4432582) Inhibition of human BRD2 bromodomain 1 expressed in bacterial expression system
- ChEMBL_1929407 (CHEMBL4432583) Inhibition of human BRD3 bromodomain 1 expressed in bacterial expression system
- ChEMBL_1929408 (CHEMBL4432584) Inhibition of human BRD4 bromodomain 1 expressed in bacterial expression system
- ChEMBL_1929409 (CHEMBL4432585) Inhibition of human BRDT bromodomain 1 expressed in bacterial expression system
- ChEMBL_1929410 (CHEMBL4432586) Inhibition of human BRD4 bromodomain 2 expressed in bacterial expression system
- ChEMBL_1929411 (CHEMBL4432587) Inhibition of human BRD2 bromodomain 2 expressed in bacterial expression system
- ChEMBL_1929412 (CHEMBL4432588) Inhibition of human BRDT bromodomain 2 expressed in bacterial expression system
- ChEMBL_1929413 (CHEMBL4432589) Inhibition of human BRD3 bromodomain 2 expressed in bacterial expression system
- ChEMBL_1929417 (CHEMBL4432593) Inhibition of human TAF1L bromodomain 2 expressed in bacterial expression system
- ChEMBL_2237044 (CHEMBL5150940) Inhibition EGFR (unknown origin) expressed in baculovirus expression system by ELISA
- ChEMBL_327457 (CHEMBL862761) Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cells
- ChEMBL_327458 (CHEMBL862762) Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cells
- ChEMBL_359728 (CHEMBL869334) Inhibition of rat AR-mediated reporter gene expression in COS7 cells
- ChEMBL_594813 (CHEMBL1042552) Inhibition of mouse recombinant serine racemase transfected in bacterial expression system
- ChEMBL_685215 (CHEMBL1287103) Inhibition of human CYP1A2 transfected in bactosome expression system by spectrofluorimetry
- ChEMBL_685216 (CHEMBL1287104) Inhibition of human CYP2C9 transfected in bactosome expression system by spectrofluorimetry
- ChEMBL_685217 (CHEMBL1287105) Inhibition of human CYP2C19 transfected in bactosome expression system by spectrofluorimetry
- ChEMBL_685218 (CHEMBL1287106) Inhibition of human CYP2D6 transfected in bactosome expression system by spectrofluorimetry
- ChEMBL_685219 (CHEMBL1287107) Inhibition of human CYP3A4 transfected in bactosome expression system by spectrofluorimetry
- ChEMBL_828863 (CHEMBL2060513) Inhibition of human recombinant BTK expressed in baculovirus expression vector system
- ChEMBL_100746 (CHEMBL710042) Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells
- ChEMBL_100747 (CHEMBL710043) Induction of pS2 mRNA expression in human MCF-7 mammary carcinoma cells
- ChEMBL_1563166 (CHEMBL3783995) Inhibition of full length recombinant human ABL1 expressed in Baculovirus expression system
- ChEMBL_1563168 (CHEMBL3783997) Inhibition of recombinant human GST-tagged DDR2 expressed in Baculovirus expression system
- ChEMBL_1614438 (CHEMBL3856507) Inhibition of human recombinant GST-tagged JAK2 expressed in baculovirus expression system
- ChEMBL_1614439 (CHEMBL3856508) Inhibition of human recombinant His-tagged FLT3 expressed in baculovirus expression system
- ChEMBL_1633333 (CHEMBL3876125) Inhibition of human recombinant full length PRKCZ expressed in baculovirus expression system
- ChEMBL_1704923 (CHEMBL4056156) Activation of PXR in human hepatocytes assessed as induction of CYP450 expression
- ChEMBL_1815487 (CHEMBL4315061) Inhibition of recombinant human His-tagged FMS expressed in baculovirus expression system
- ChEMBL_1815513 (CHEMBL4315087) Inhibition of recombinant human GST-tagged RET expressed in baculovirus expression system
- ChEMBL_1855361 (CHEMBL4356090) Inhibition of His-tagged recombinant human PIK3CG expressed in Baculovirus expression system
- ChEMBL_1887879 (CHEMBL4389556) Inhibition of BTK in human PBMC assessed as reduction in CD69 expression
- ChEMBL_1899306 (CHEMBL4401421) Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression system
- ChEMBL_1899307 (CHEMBL4401422) Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression system
- ChEMBL_1983367 (CHEMBL4616773) Inhibition of BTK in human PBMC assessed as reduction in TNFalpha expression
- ChEMBL_2101165 (CHEMBL4809561) Inhibition of BRD4 (unknown origin) assessed as reduction in c-Myc expression
- ChEMBL_2110457 (CHEMBL4819307) Inhibition of human HDAC1 expressed in baculovirus expression system by fluorescence method
- ChEMBL_2424484 Inhibition of BTK in human TMD8 cells assessed as reduction in CD19 expression
- ChEMBL_2424485 Inhibition of BTK in human TMD8 cells assessed as reduction in CD36 expression
- ChEMBL_2496598 Antagonist activity at AR (unknown origin) expressed in chemically activated Luciferase expression system
- ChEMBL_310535 (CHEMBL834430) Effective concentration DP2 mediated expression of the adhesion molecule CD11b in eosinophils
- ChEMBL_327456 (CHEMBL862760) Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cells
- ChEMBL_329857 (CHEMBL870579) Inhibition of the expression of AP1-luciferase by TPA-stimulated NIH3T3 cells
- ChEMBL_741377 (CHEMBL1764903) Induction of human PPARdelta-mediated CPT1a gene expression in human skeletal muscle
- ChEMBL_741378 (CHEMBL1764904) Induction of human PPARdelta-mediated PDK4 gene expression in human skeletal muscle
- ChEMBL_800208 (CHEMBL1947770) Inhibition of wild-type EGFR expressed using baculovirus expression system by ELISA
- ChEMBL_99630 (CHEMBL707544) Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells
- ChEBML_1689486 Inhibition of partial length human MEK5 expressed in mammalian expression system by KINOMEscan assay
- ChEBML_1689487 Inhibition of partial length human RIOK2 expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1691770 (CHEMBL4042419) Inhibition of human full length His-tagged PI3Kdelta expressed in baculovirus expression system
- ChEMBL_1719139 (CHEMBL4134139) Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression
- ChEMBL_1738055 (CHEMBL4153805) Inhibition of human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system
- ChEMBL_1738056 (CHEMBL4153806) Inhibition of human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system
- ChEMBL_1738057 (CHEMBL4153807) Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system
- ChEMBL_1738058 (CHEMBL4153808) Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system
- ChEMBL_1750648 (CHEMBL4185408) Inhibition of human PLK4 (M1 to S273 residues) expressed in mammalian expression system
- ChEMBL_1791729 (CHEMBL4263648) Inhibition of recombinant human Haspin expressed in Baculovirus expression system by Adapta assay
- ChEMBL_1815512 (CHEMBL4315086) Inhibition of recombinant human His-tagged VEGFR 2 expressed in baculovirus expression system
- ChEMBL_1855360 (CHEMBL4356089) Inhibition of His-tagged recombinant human PIK3CA/PIK3R1 expressed in Baculovirus expression system
- ChEMBL_2169143 (CHEMBL5054202) Inhibition of human MUSK expressed in baculovirus expression system by mobility shift assay
- ChEMBL_2302350 Inhibition of EGFR T790M mutant (unknown origin) expressed in baculovirus expression system by ELISA
- ChEMBL_2302351 Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system by ELISA
- ChEMBL_332772 (CHEMBL859110) Effect on transactivation of ALP gene expression in HEK293 cells transfected with hERalpha
- ChEMBL_332773 (CHEMBL859111) Effect on transactivation of ALP gene expression in HEK293 cells transfected with hERbeta
- ChEMBL_462715 (CHEMBL928636) Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system
- ChEMBL_675741 (CHEMBL1272375) Inhibition of Pin1-mediated cyclin D1 expression in serum starved human PC3 cells
- ChEBML_1661461 Inhibition of human full length N-terminal GST-tagged MNK2 expressed in baculovirus expression system
- ChEBML_1661462 Inhibition of human recombinant full length His-tagged PIM-1 expressed in baculovirus expression system
- ChEMBL_100612 (CHEMBL715092) Inhibition of steady-state expression of Raf-1 in MCF-7 breast cancer cells
- ChEMBL_1336810 (CHEMBL3241501) Binding affinity to MDM2 in human SJSA1 cells assessed as induction of p21 expression
- ChEMBL_1503828 (CHEMBL3592812) Activation of aryl hydrocarbon receptor (unknown origin) assessed as induction of CYP1A2 mRNA expression
- ChEMBL_1633245 (CHEMBL3876037) Inhibition of human recombinant full length His-tagged NUAK1 expressed in baculovirus expression system
- ChEMBL_1633247 (CHEMBL3876039) Inhibition of human recombinant full length His-tagged AURKB expressed in baculovirus expression system
- ChEMBL_1633253 (CHEMBL3876045) Inhibition of human recombinant full length His-tagged PDK1 expressed in baculovirus expression system
- ChEMBL_1633260 (CHEMBL3876052) Inhibition of human recombinant full length His-tagged RPS6KA3 expressed in baculovirus expression system
- ChEMBL_1633274 (CHEMBL3876066) Inhibition of human recombinant full length GST-tagged SPHK1 expressed in baculovirus expression system
- ChEMBL_1633278 (CHEMBL3876070) Inhibition of human recombinant full length GST-tagged IKKbeta expressed in baculovirus expression system
- ChEMBL_1633279 (CHEMBL3876071) Inhibition of human recombinant full length GST-tagged IKKepsilon expressed in baculovirus expression system
- ChEMBL_1633281 (CHEMBL3876073) Inhibition of human recombinant full length His-tagged IRAK4 expressed in baculovirus expression system
- ChEMBL_1633282 (CHEMBL3876074) Inhibition of human recombinant full length His-tagged CSNK2A1 expressed in baculovirus expression system
- ChEMBL_1633284 (CHEMBL3876076) Inhibition of human recombinant full length His-tagged SRPK1 expressed in baculovirus expression system
- ChEMBL_1633290 (CHEMBL3876082) Inhibition of human recombinant full length GST-tagged BRAF expressed in baculovirus expression system
- ChEMBL_1633293 (CHEMBL3876085) Inhibition of human recombinant full length His-tagged CHEK2 expressed in baculovirus expression system
- ChEMBL_1633294 (CHEMBL3876086) Inhibition of human recombinant full length GST-tagged MST4 expressed in baculovirus expression system
- ChEMBL_1633295 (CHEMBL3876087) Inhibition of human recombinant full length His-tagged GSK3B expressed in baculovirus expression system
- ChEMBL_1633296 (CHEMBL3876088) Inhibition of human recombinant full length His-tagged STK22D expressed in baculovirus expression system
- ChEMBL_1633300 (CHEMBL3876092) Inhibition of human recombinant full length His-tagged ADRBK1 expressed in baculovirus expression system
- ChEMBL_1633301 (CHEMBL3876093) Inhibition of human recombinant full length His-tagged AKT1alpha expressed in baculovirus expression system
- ChEMBL_1633302 (CHEMBL3876094) Inhibition of human recombinant full length His-tagged AKT2beta expressed in baculovirus expression system
- ChEMBL_1633303 (CHEMBL3876095) Inhibition of human recombinant full length His-tagged AKT3gamma expressed in baculovirus expression system
- ChEMBL_1633306 (CHEMBL3876098) Inhibition of human recombinant full length His-tagged CHEK1 expressed in baculovirus expression system
- ChEMBL_1633307 (CHEMBL3876099) Inhibition of human recombinant full length GST-tagged CSNK1A1 expressed in baculovirus expression system
- ChEMBL_1633309 (CHEMBL3876101) Inhibition of human recombinant full length GST-tagged DYRK1A expressed in baculovirus expression system
- ChEMBL_1633311 (CHEMBL3876103) Inhibition of human recombinant full length GST-tagged GRK4 expressed in baculovirus expression system
- ChEMBL_1633312 (CHEMBL3876104) Inhibition of human recombinant full length GST-tagged GRK6 expressed in baculovirus expression system
- ChEMBL_1633315 (CHEMBL3876107) Inhibition of human recombinant full length His-tagged MAP2K1 expressed in baculovirus expression system
- ChEMBL_1633316 (CHEMBL3876108) Inhibition of human recombinant full length His-tagged MAP2K6 expressed in baculovirus expression system
- ChEMBL_1633317 (CHEMBL3876109) Inhibition of human recombinant full length His-tagged MAPK13 expressed in baculovirus expression system
- ChEMBL_1633319 (CHEMBL3876111) Inhibition of human recombinant full length His-tagged MAPK9 expressed in baculovirus expression system
- ChEMBL_1633321 (CHEMBL3876113) Inhibition of human recombinant full length His-tagged MAPKAPK5 expressed in baculovirus expression system
- ChEMBL_1633322 (CHEMBL3876114) Inhibition of human recombinant full length His-tagged NEK2 expressed in baculovirus expression system
- ChEMBL_1633323 (CHEMBL3876115) Inhibition of human recombinant full length GST-tagged NEK6 expressed in insect expression system
- ChEMBL_1633324 (CHEMBL3876116) Inhibition of human recombinant full length GST-tagged PAK1 expressed in baculovirus expression system
- ChEMBL_1633327 (CHEMBL3876119) Inhibition of human recombinant full length GST-tagged PKN1 expressed in baculovirus expression system
- ChEMBL_1633328 (CHEMBL3876120) Inhibition of human recombinant full length His-tagged PIM1 expressed in baculovirus expression system
- ChEMBL_1633329 (CHEMBL3876121) Inhibition of human recombinant full length His-tagged PLK1 expressed in baculovirus expression system
- ChEMBL_1633331 (CHEMBL3876123) Inhibition of human recombinant full length His-tagged PRKCI expressed in baculovirus expression system
- ChEMBL_1633332 (CHEMBL3876124) Inhibition of human recombinant full length His-tagged PRKCQ expressed in baculovirus expression system
- ChEMBL_1633340 (CHEMBL3876132) Inhibition of human recombinant full length GST-tagged TBK1 expressed in insect expression system
- ChEMBL_1633343 (CHEMBL3876135) Inhibition of human recombinant full length GST-tagged NEK4 expressed in baculovirus expression system
- ChEMBL_1633344 (CHEMBL3876136) Inhibition of human recombinant full length His-tagged MAPK8 expressed in baculovirus expression system
- ChEMBL_1652345 (CHEMBL4001600) Inhibition of full length GST-tagged recombinant human DYRK1A expressed in baculovirus expression system
- ChEMBL_1652346 (CHEMBL4001601) Inhibition of full length GST-tagged recombinant human DYRK1B expressed in baculovirus expression system
- ChEMBL_1652347 (CHEMBL4001602) Inhibition of full length GST-tagged recombinant human CSNK1G3 expressed in baculovirus expression system
- ChEMBL_1661527 (CHEMBL4011139) Inhibition of recombinant full length human His-tagged GSK3B expressed in baculovirus expression system
- ChEMBL_1661528 (CHEMBL4011140) Inhibition of recombinant full length human GST-tagged ITK expressed in baculovirus expression system
- ChEMBL_1661529 (CHEMBL4011141) Inhibition of recombinant human GST-tagged MER cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1661532 (CHEMBL4011144) Inhibition of recombinant human GST-tagged RET cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1661533 (CHEMBL4011145) Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression system
- ChEMBL_1661534 (CHEMBL4011146) Inhibition of recombinant human GST-tagged RON cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1676866 (CHEMBL4027009) Binding affinity wild type human IRAK3 (V147 to E596) expressed in bacterial expression system
- ChEMBL_1676867 (CHEMBL4027010) Binding affinity wild type human IRAK2 (T180 to T519) expressed in mammalian expression system
- ChEMBL_1691771 (CHEMBL4042420) Inhibition of recombinant human full length His-tagged PI3Kalpha expressed in baculovirus expression system
- ChEMBL_1714184 (CHEMBL4124233) Inhibition of recombinant human full length GST-tagged DRAK1 expressed in baculovirus expression system
- ChEMBL_1714185 (CHEMBL4124234) Inhibition of recombinant human full length GST-tagged CLK4 expressed in baculovirus expression system
- ChEMBL_1738054 (CHEMBL4153804) Inhibition of human m-TOR (L1382 to W2549 residues) expressed in mammalian expression system
- ChEMBL_1758805 (CHEMBL4193813) Inhibition of BRD4 in human MV411 cells assessed as reduction in MYC mRNA expression
- ChEMBL_1760957 (CHEMBL4195965) Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system
- ChEMBL_1767519 (CHEMBL4219631) Binding affinity to human full length wild-type TBK1 expressed in mammalian expression system
- ChEMBL_1767530 (CHEMBL4219642) Binding affinity to human full length wild-type IKKepsilon expressed in mammalian expression system
- ChEMBL_1791728 (CHEMBL4263647) Inhibition of recombinant human Dyrk1A expressed in Baculovirus expression system by Z'-LYTE assay
- ChEMBL_1810649 (CHEMBL4310109) Binding affinity to human p38alpha (1 to 360 residues) expressed in bacterial expression system
- ChEMBL_1815514 (CHEMBL4315088) Inhibition of recombinant human full length His-tagged Src expressed in baculovirus expression system
- ChEMBL_1824535 (CHEMBL4324299) Inhibition of recombinant full length human His-tagged ARK5 expressed in baculovirus expression system
- ChEMBL_1830008 (CHEMBL4329882) Inhibition of recombinant human full length GST-tagged BRAF expressed in baculovirus expression system
- ChEMBL_1830009 (CHEMBL4329883) Inhibition of recombinant human GST-tagged BRAF V600E mutant expressed in baculovirus expression system
- ChEMBL_1855359 (CHEMBL4356088) Inhibition of His-tagged recombinant human PI3K p110delta/p85alpha expressed in Baculovirus expression system
- ChEMBL_1899308 (CHEMBL4401423) Binding affinity to human FLT3 ITD/D835V double mutant expressed in baculovirus expression system
- ChEMBL_1899309 (CHEMBL4401424) Binding affinity to human FLT3 ITD/F691L double mutant expressed in baculovirus expression system
- ChEMBL_1906199 (CHEMBL4408557) Inhibition of N-terminal His-tagged human IDO2 expressed in Escherichia coli expression system
- ChEMBL_1906200 (CHEMBL4408558) Inhibition of N-terminal His-tagged human TDO expressed in Escherichia coli expression system
- ChEMBL_2015009 (CHEMBL4668587) Inhibition of human ROCK2 expressed in baculovirus expression system by Kinase-Glo luminescent Assay
- ChEMBL_2015010 (CHEMBL4668588) Inhibition of human ROCK1 expressed in baculovirus expression system by Kinase-Glo luminescent Assay
- ChEMBL_2131659 (CHEMBL4841174) Inhibition of sEH (unknown origin) expressed in baculovirus expression system incubated for 1 hr
- ChEMBL_2184484 (CHEMBL5096566) Inhibition of recombinant full length human His-tagged NUAK1 expressed in Baculovirus expression system
- ChEMBL_2215183 (CHEMBL5128315) Inhibition of human TLR4 expressed in HEK293-Blue hTLR4 cells assessed as SEAP expression
- ChEMBL_2302349 Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system by ELISA
- ChEMBL_2572672 Inhibition of His-tagged recombinant full length FES (unknown origin) expressed in baculovirus expression system
- ChEMBL_2572679 Inhibition of GST-tagged recombinant full length FRK (unknown origin) expressed in baculovirus expression system
- ChEMBL_492929 (CHEMBL946255) Transactivation of ERalpha in human MCF7-2a cells assessed as luciferase reporter gene expression
- ChEMBL_89065 (CHEMBL698852) Tested for inhibition of ICAM expression by ELISA at the dose of 30 uM
- ChEMBL_89066 (CHEMBL698853) Tested for inhibition of ICAM expression by ELISA at the dose of 30 uM
- ChEBML_1622035 Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay
- ChEBML_1687833 Inhibition of human BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEBML_1687835 Inhibition of human CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687836 Inhibition of human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687838 Inhibition of human PCAF (G715 to D831 residues) expressed in mammalian expression system by BROMOscan assay
- ChEBML_1687839 Inhibition of human SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687841 Inhibition of human TAF1L (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687842 Inhibition of human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687843 Inhibition of human CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687844 Inhibition of human BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687845 Inhibition of human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687847 Inhibition of human BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687851 Inhibition of human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1563167 (CHEMBL3783996) Inhibition of GST-tagged human DDR1 (440 to 876 residues) expressed in Baculovirus expression system
- ChEMBL_1622834 (CHEMBL3865186) Binding affinity to STAT3 (unknown origin) expressed in Escherichia coli expression system by SPR assay
- ChEMBL_1625832 (CHEMBL3868301) Inhibition of PI3K-delta in mouse splenocytes assessed as inhibition anti-IgM induced CD86 expression
- ChEMBL_1628980 (CHEMBL3871606) Inhibition of human recombinant full-length His-tagged Aurora B expressed in baculovirus expression system
- ChEMBL_1633248 (CHEMBL3876040) Inhibition of human full length wild type DYKDDDDK-tagged LRRK2 expressed in baculovirus expression system
- ChEMBL_1633298 (CHEMBL3876090) Inhibition of human full length N-terminal GST-tagged GSK3A expressed in baculovirus expression system
- ChEMBL_1652340 (CHEMBL4001595) Inhibition of N-terminal His-tagged truncated recombinant human ECE1 expressed in mammalian expression system
- ChEMBL_1654182 (CHEMBL4003548) Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan method
- ChEMBL_1654194 (CHEMBL4003560) Binding affinity to human partial length BRPF3 expressed in bacterial expression system by BROMOscan method
- ChEMBL_1661462 (CHEMBL4011074) Inhibition of human recombinant full length His-tagged PIM-1 expressed in baculovirus expression system
- ChEMBL_1676865 (CHEMBL4027008) Binding affinity to wild type human IRAK4 (M1 to S460) expressed in mammalian expression system
- ChEMBL_1676869 (CHEMBL4027012) Binding affinity to wild type human IRAK1 (R194 to S712) expressed in mammalian expression system
- ChEMBL_1710134 (CHEMBL4120183) Inhibition of full length recombinant human DMPK expressed in baculovirus expression system by FRET assay
- ChEMBL_1710139 (CHEMBL4120188) Inhibition of recombinant human GST-tagged MLK1 expressed in baculovirus expression system by FRET assay
- ChEMBL_1727506 (CHEMBL4142784) Inhibition of recombinant human GST-tagged ALK expressed in baculovirus expression system by Z'LYTE assay
- ChEMBL_1727507 (CHEMBL4142785) Inhibition of recombinant human GST-tagged ROS1 expressed in baculovirus expression system by Z'LYTE assay
- ChEMBL_1750706 (CHEMBL4185466) Binding affinity to human partial length TRIM24 expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751631 (CHEMBL4186391) Inhibition of P300/CBP in human MV4-11 cells assessed as downregulation of MYC expression
- ChEMBL_1792689 (CHEMBL4264608) Inhibition of recombinant full length His-tagged human CDK1/CyclinB expressed in baculovirus expression system
- ChEMBL_1792690 (CHEMBL4264609) Inhibition of recombinant full length His-tagged human CDK2/CyclinA expressed in baculovirus expression system
- ChEMBL_1792694 (CHEMBL4264613) Inhibition of recombinant full length His-tagged human CDK8/CyclinC expressed in baculovirus expression system
- ChEMBL_1792695 (CHEMBL4264614) Inhibition of recombinant full length His-tagged human CDK9/CyclinT1 expressed in baculovirus expression system
- ChEMBL_1813004 (CHEMBL4312578) Inhibition of human ERG expressed in mammalian expression system by Q-patch clamp electrophysiology method
- ChEMBL_1824537 (CHEMBL4324301) Inhibition of recombinant full length human His-tagged CDK5/p35 expressed in baculovirus expression system
- ChEMBL_1909768 (CHEMBL4412214) Inhibition of human wild type FLT3 (V592 to Y969 residues) expressed in bacterial expression system
- ChEMBL_1922913 (CHEMBL4425869) Binding affinity to human partial length BAZ2A expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1922914 (CHEMBL4425870) Binding affinity to human partial length TRIM24 expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1922915 (CHEMBL4425871) Binding affinity to human partial length EP300 expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1922916 (CHEMBL4425872) Binding affinity to human partial length BAZ2B expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1922918 (CHEMBL4425874) Binding affinity to human partial length SMARCA2 expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1922919 (CHEMBL4425875) Binding affinity to human partial length SMARCA4 expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1929588 (CHEMBL4432764) Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system by kinase-glo luminescence assay
- ChEMBL_1929589 (CHEMBL4432765) Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system by kinase-glo luminescence assay
- ChEMBL_1929590 (CHEMBL4432766) Inhibition of PI3Kgamma (unknown origin) expressed in baculovirus expression system by kinase-glo luminescence assay
- ChEMBL_1929591 (CHEMBL4432767) Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system by kinase-glo luminescence assay
- ChEMBL_1977814 (CHEMBL4610949) Inhibition of recombinant full-length His-tagged human Aurora A expressed in baculovirus expression system
- ChEMBL_1977815 (CHEMBL4610950) Inhibition of recombinant full-length His-tagged human Aurora B expressed in baculovirus expression system
- ChEMBL_1977816 (CHEMBL4610951) Inhibition of recombinant full-length His-tagged human Aurora C expressed in baculovirus expression system
- ChEMBL_1983368 (CHEMBL4616774) Inhibition of BTK in human peripheral B cells assessed as reduction in CD69 surface expression
- ChEMBL_1983369 (CHEMBL4616775) Inhibition of BTK in human peripheral B cells assessed as reduction in CD86 surface expression
- ChEMBL_1983370 (CHEMBL4616776) Inhibition of BTK in human memory B cells assessed as reduction in CD86 surface expression
- ChEMBL_1995441 (CHEMBL4629336) Agonist activity at RORgammat in mouse whole blood assessed as induction of IL-17A expression
- ChEMBL_199710 (CHEMBL802066) Transcriptional repression of IL-1 stimulated IL-6 expression in native cells compared to Dexamethasone
- ChEMBL_2049097 (CHEMBL4703796) Binding affinity to human partial length TRKA expressed in mammalian expression system by kinomescan method
- ChEMBL_2049101 (CHEMBL4703800) Binding affinity to human partial length TRKB expressed in mammalian expression system by kinomescan method
- ChEMBL_2169144 (CHEMBL5054203) Inhibition of human full length SRC expressed in baculovirus expression system by mobility shift assay
- ChEMBL_2220409 (CHEMBL5133743) Inhibition of recombinant His-tagged human TrKA expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_2227453 (CHEMBL5140966) Antagonist activity at Androgen receptor in human LNCaP cells assessed as inhibition of PSA expression
- ChEMBL_2287562 Inhibition of GST-tagged human recombinant CDK11 (1 to 795 residues) expressed in baculovirus expression system
- ChEMBL_2317884 Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression system
- ChEMBL_2349739 Inhibition of TEAD1 mediating gene expression in human MCF7 cells incubated overnight by luciferase reporter assay
- ChEMBL_2426858 Inhibition of human recombinant USP1 expressed in baculovirus expressed in Bac-to-Bac baculovirus expression system
- ChEMBL_596937 (CHEMBL1048878) Inhibition of human recombinant ACC 1 expressed in baculovirus expression system by FAS-coupled assay
- ChEMBL_596938 (CHEMBL1048879) Inhibition of human recombinant ACC 2 expressed in baculovirus expression system by FAS-coupled assay
- ChEMBL_60885 (CHEMBL673532) Tested for inhibition of E-selectin expression by ELISA at the dose of 30 uM
- ChEMBL_60886 (CHEMBL673533) Tested for inhibition of E-selection expression by ELISA at the dose of 30 uM
- ChEMBL_664575 (CHEMBL1260116) Inhibition of human recombinant GST-tagged CDC25A expressed in bacterial expression system after 2 hrs
- ChEMBL_664576 (CHEMBL1260117) Inhibition of human recombinant GST-tagged CDC25C expressed in bacterial expression system after 2 hrs
- ChEMBL_690164 (CHEMBL1634184) Inhibition of human recombinant soluble epoxide hydrolase expressed in baculovirus expression system by fluorimetric assay
- ChEMBL_790695 (CHEMBL1926148) Inhibition of CDK7 in human HT29 cells assessed as reduction in RNA polymerase 2 expression
- ChEMBL_790696 (CHEMBL1926149) Inhibition of CDK9 in human HT29 cells assessed as reduction in RNA polymerase 2 expression
- FXR Activity Assay To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid, reporter plasmid, and pCMVbeta as internal control in each well, using the Lipofectamine 2000 reagent.
- ChEBML_1681144 Inhibition of full length recombinant human His-tagged LCK expressed in Baculovirus expression system by Z'Lyte assay
- ChEBML_1681145 Inhibition of full length recombinant human GST-tagged MKNK2 expressed in Baculovirus expression system by Z'Lyte assay
- ChEMBL_1563169 (CHEMBL3783998) Inhibition of His-tagged recombinant human c-Kit without catalytic domain expressed in mammalian expression system
- ChEMBL_1563171 (CHEMBL3784000) Inhibition of full length recombinant human C-terminal His-tagged SRC expressed in Baculovirus expression system
- ChEMBL_1588043 (CHEMBL3824978) Inhibition of partial-length human FLT3 ITD mutant expressed in bacterial expression system by KINOMEscan assay
- ChEMBL_1588044 (CHEMBL3824979) Inhibition of partial-length human wild type HASPIN expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1588045 (CHEMBL3824980) Inhibition of partial-length human KIT A829P mutant expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1622035 (CHEMBL3864387) Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay
- ChEMBL_1623195 (CHEMBL3865547) Inhibition of N-terminal 6His-tagged full length recombinant human YES expressed in baculovirus expression system
- ChEMBL_1623199 (CHEMBL3865551) Inhibition of N-Terminal His6-tagged full length recombinant human FYN expressed in baculovirus expression system
- ChEMBL_1623201 (CHEMBL3865553) Inhibition of N-terminal 6His-tagged full length recombinant human LCK expressed in baculovirus expression system
- ChEMBL_1633258 (CHEMBL3876050) Inhibition of human recombinant full length GST/His-tagged CDK5/P25 expressed in baculovirus expression system
- ChEMBL_1633265 (CHEMBL3876057) Inhibition of human recombinant full length His-tagged ABL1 cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633270 (CHEMBL3876062) Inhibition of human recombinant full length His-tagged BMX cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633272 (CHEMBL3876064) Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in baculovirus expression system
- ChEMBL_1633273 (CHEMBL3876065) Inhibition of human recombinant full length His-tagged PIK3 P110D/P85A expressed in baculovirus expression system
- ChEMBL_1633289 (CHEMBL3876081) Inhibition of human recombinant full length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633313 (CHEMBL3876105) Inhibition of human recombinant full length GST-tagged ITK cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633334 (CHEMBL3876126) Inhibition of human recombinant full length His-tagged PTK6 cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633342 (CHEMBL3876134) Inhibition of human recombinant full length His-tagged ZAP70 cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1634509 (CHEMBL3877407) Inhibition of human TYK2 (V877 to C1187 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1634510 (CHEMBL3877408) Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1654183 (CHEMBL4003549) Binding affinity to human partial length PCAF bromodomain expressed in mammalian expression system by BROMOscan method
- ChEMBL_1658727 (CHEMBL4008339) Inhibition of human GST-tagged DDR1 catalytic domain expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_1734994 (CHEMBL4150530) Inhibition of human CDK19 (M1 to N360 residues) expressed in bacterial expression system by KINOMEscan assay
- ChEMBL_1792068 (CHEMBL4263987) Inhibition of full length GST-tagged human ACVR2A expressed in Baculovirus expression system by LanthaScreen assay
- ChEMBL_1792692 (CHEMBL4264611) Inhibition of recombinant full length His/GST-tagged human CDK5/p25 expressed in baculovirus expression system
- ChEMBL_1804137 (CHEMBL4276429) Inhibition of human mTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1804138 (CHEMBL4276430) Inhibition of human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1804139 (CHEMBL4276431) Inhibition of human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1804140 (CHEMBL4276432) Inhibition of human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1804141 (CHEMBL4276433) Inhibition of human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1804142 (CHEMBL4276434) Inhibition of human PI4Kbeta (1 to 828 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1804143 (CHEMBL4276435) Inhibition of human VPS34 (282 to 879 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1815517 (CHEMBL4315091) Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_1824536 (CHEMBL4324300) Inhibition of recombinant full length human GST/His-tagged CDK5/p25 expressed in baculovirus expression system
- ChEMBL_1826712 (CHEMBL4326586) Inhibition of human recombinant His-tagged AXL (473 to end residues) expressed in insect expression system
- ChEMBL_1846235 (CHEMBL4346776) Inhibition of human recombinant full-length His-tagged CDK1/cyclin B1 expressed in baculovirus expression system
- ChEMBL_1846239 (CHEMBL4346780) Inhibition of human recombinant full length His-tagged CDK9/cyclin K expressed in baculovirus expression system
- ChEMBL_1874809 (CHEMBL4376098) Binding affinity to KEAP1 (unknown origin) expressed in baculovirus expression system by surface plasmon resonance analysis
- ChEMBL_1922917 (CHEMBL4425873) Binding affinity to human partial length PBRM1(2) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1934063 (CHEMBL4479715) Inhibition of recombinant human His-tagged EGFR expressed in mammalian expression system by Z'-LYTE assay
- ChEMBL_1934064 (CHEMBL4479716) Inhibition of recombinant human His-tagged cytoplasmic EPHA3 expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_1934119 (CHEMBL4479771) Inhibition of full-length recombinant human PRKCZ expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1988887 (CHEMBL4622434) Binding affinity to recombinant human FLT3 ITD mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_1991906 (CHEMBL4625641) Inhibition of human wild type partial length TNIK (D4-K311 residues) expressed in bacterial expression system
- ChEMBL_2047038 (CHEMBL4701737) Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_2169141 (CHEMBL5054200) Inhibition of human DDR1 (444 - 876 residues) expressed in baculovirus expression system by mobility shift assay
- ChEMBL_2169142 (CHEMBL5054201) Inhibition of human ITK (2 - 620 residues) expressed in baculovirus expression system by mobility shift assay
- ChEMBL_2169145 (CHEMBL5054204) Inhibition of human TEC (359 - 631 residues) expressed in baculovirus expression system by mobility shift assay
- ChEMBL_2220449 (CHEMBL5133783) Inhibition of recombinant GST-tagged human FLT3 expressed in baculovirus expression system by tyrosine kinase assay
- ChEMBL_2238563 (CHEMBL5152459) Inhibition of recombinant C-terminal 6-His tagged Plasmodium falciparum SUB1 expressed in baculovirus expression system
- ChEMBL_2285702 Inhibition of recombinant full length His-tagged human PDK1 expressed in baculovirus expression system by FRET assay
- ChEMBL_2424426 Inhibition of human full-length wild type BTK (M1 to S659 residues) expressed in mammalian expression system
- ChEMBL_2572671 Inhibition of His-tagged recombinant FER (541 to 822 residues) (unknown origin) expressed in baculovirus expression system
- ChEMBL_2572678 Inhibition of His-tagged recombinant TRKC (510 to 825 residues) (unknown origin) expressed in baculovirus expression system
- ChEMBL_333818 (CHEMBL864088) Effect on binding to ER in Ad5-wt-ER-infected HAECT1 cells by creatine kinase expression
- ChEMBL_466159 (CHEMBL950163) Antagonist activity at GR in SW1353/MMTV5 cells assessed as inhibition of dexamethasone-induced luciferase expression
- ChEMBL_479547 (CHEMBL931543) Activity at glucocorticoid receptor assessed as repression of TNFalpha and IL1 beta-induced E-selectin expression
- ChEMBL_61626 (CHEMBL673082) In vitro binding affinity towards Dopamine receptor D2L, using [3H]spiroperidol radioligand in Sf9 baculovirus expression.
- ChEMBL_881928 (CHEMBL2212531) Inhibition of HIF-1alpha-mediated VEGF expression in human Hep3b cells by luciferase reporter gene assay
- ChEMBL_986179 (CHEMBL2433084) Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs
- ChEBML_1614096 Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assay
- ChEBML_1614097 Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assay
- ChEBML_1653997 Binding affinity to recombinant human CLK2 (D144 to R498 residues) expressed in bacterial expression system by KinomeScan assay
- ChEBML_1653999 Binding affinity to recombinant human CLK4 (R135 to K481 residues) expressed in bacterial expression system by KinomeScan assay
- ChEBML_1661463 Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system
- ChEBML_1681141 Inhibition of GST-tagged human DDR1 (440 to 876 residues) expressed in Baculovirus expression system by Z'Lyte assay
- ChEBML_1681142 Inhibition of GST-tagged human DDR2 (427 to 855 residues) expressed in Baculovirus expression system by Z'Lyte assay
- ChEBML_1687840 Inhibition of human TRIM24-phd-bromo (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687848 Inhibition of human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687849 Inhibition of human WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1687850 Inhibition of human TRIM33-phd-bromo (D882 to A1087 residues) expressed in bacterial expression system by BROMOscan assay
- ChEBML_1692382 Inhibition of recombinant full length His-tagged human PIM1 expressed in baculovirus expression system by Z'-Lyte assay
- ChEBML_1692383 Inhibition of recombinant full length GST-tagged human PIM2 expressed in baculovirus expression system by Z'-Lyte assay
- ChEMBL_1348183 (CHEMBL3270298) Inhibition of Syk in goat antihuman IgE-induced CD63 expression in human whole blood by FACS analysis
- ChEMBL_1573292 (CHEMBL3804024) Inhibition of wild-type EGFR (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA
- ChEMBL_1588046 (CHEMBL3824981) Inhibition of partial-length human wild type PDGFR-alpha expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1622880 (CHEMBL3865232) Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1622881 (CHEMBL3865233) Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1622882 (CHEMBL3865234) Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1622883 (CHEMBL3865235) Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1622884 (CHEMBL3865236) Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1623194 (CHEMBL3865546) Inhibition of N-terminal FLAG-tagged recombinant human PAK1 (150-end residues) expressed in baculovirus expression system
- ChEMBL_1623216 (CHEMBL3865568) Binding affinity to human PAK1 (S149 to H545 residues) expressed in bacterial expression system by KINOMEscan assay
- ChEMBL_1623217 (CHEMBL3865569) Binding affinity to human PAK2 (P151 to R525 residues) expressed in bacterial expression system by KINOMEscan assay
- ChEMBL_1633261 (CHEMBL3876053) Inhibition of human recombinant full length His-tagged CDK7/cyclin H/MNAT1 expressed in baculovirus expression system
- ChEMBL_1633288 (CHEMBL3876080) Inhibition of human full length N-terminal GST-tagged HCK cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1647794 (CHEMBL3996850) Inhibition of PI3Kdelta in human whole blood assessed as suppression of CD69 expression incubated for 60 mins
- ChEMBL_1669391 (CHEMBL4019279) Binding affinity to human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1669392 (CHEMBL4019280) Binding affinity to human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1669393 (CHEMBL4019281) Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1669394 (CHEMBL4019282) Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1669395 (CHEMBL4019283) Binding affinity to human mTOR (L1382 to W2549 residues) expressed in mammalian expression system at 10 uM
- ChEMBL_1669396 (CHEMBL4019284) Binding affinity to human PI3KC2beta (M1 to L1634 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1669397 (CHEMBL4019285) Binding affinity to human VPS34 (S282 to H879 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1669398 (CHEMBL4019286) Binding affinity to human PI4KCbeta (M1 to M828 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_1670372 (CHEMBL4020260) Binding affinity to human BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1670373 (CHEMBL4020261) Binding affinity to human BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670374 (CHEMBL4020262) Binding affinity to human CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670375 (CHEMBL4020263) Binding affinity to human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670377 (CHEMBL4020265) Binding affinity to human PCAF (G715 to D831 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1670379 (CHEMBL4020267) Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670383 (CHEMBL4020271) Binding affinity to human EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670384 (CHEMBL4020272) Binding affinity to human BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670385 (CHEMBL4020273) Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670386 (CHEMBL4020274) Binding affinity to human BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670387 (CHEMBL4020275) Binding affinity to human BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1701638 (CHEMBL4052871) Inhibition of recombinant human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1701639 (CHEMBL4052872) Inhibition of recombinant human TAF1 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1710128 (CHEMBL4120177) Inhibition of recombinant His-tagged human FLT3 cytoplasmic domain expressed in baculovirus expression system by FRET assay
- ChEMBL_1710129 (CHEMBL4120178) Inhibition of recombinant GST-tagged human PAK4 catalytic domain expressed in baculovirus expression system by FRET assay
- ChEMBL_1710130 (CHEMBL4120179) Inhibition of recombinant full length His-tagged human STK16 expressed in baculovirus expression system by FRET assay
- ChEMBL_1710135 (CHEMBL4120184) Inhibition of recombinant GST-tagged human EphA7 cytoplasmic domain expressed in baculovirus expression system by FRET assay
- ChEMBL_1710137 (CHEMBL4120186) Inhibition of recombinant full length His-tagged human JNK1alpha1 expressed in baculovirus expression system by FRET assay
- ChEMBL_1710138 (CHEMBL4120187) Inhibition of recombinant full length GST-tagged human JNK3 expressed in baculovirus expression system by FRET assay
- ChEMBL_1710140 (CHEMBL4120189) Inhibition of recombinant human full length GST-tagged MLK2 expressed in baculovirus expression system by FRET assay
- ChEMBL_1710141 (CHEMBL4120190) Inhibition of recombinant human full length GST-tagged MLK3 expressed in baculovirus expression system by FRET assay
- ChEMBL_1717888 (CHEMBL4132888) Binding affinity to human BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1717889 (CHEMBL4132889) Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735486 (CHEMBL4151022) Binding affinity to human CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735487 (CHEMBL4151023) Binding affinity to human CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735488 (CHEMBL4151024) Binding affinity to human EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735489 (CHEMBL4151025) Binding affinity to human ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735490 (CHEMBL4151026) Binding affinity to human ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735491 (CHEMBL4151027) Binding affinity to human BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735492 (CHEMBL4151028) Binding affinity to human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735493 (CHEMBL4151029) Binding affinity to human BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735494 (CHEMBL4151030) Binding affinity to human BRD7 (L125 to R254 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735497 (CHEMBL4151033) Binding affinity to human BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735498 (CHEMBL4151034) Binding affinity to human BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735499 (CHEMBL4151035) Binding affinity to human BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735500 (CHEMBL4151036) Binding affinity to human FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735501 (CHEMBL4151037) Binding affinity to human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735504 (CHEMBL4151040) Binding affinity to human PCAF (G715 to D831 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735505 (CHEMBL4151041) Binding affinity to human SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735506 (CHEMBL4151042) Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735509 (CHEMBL4151045) Binding affinity to human TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1740165 (CHEMBL4155915) Binding affinity to human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_1740166 (CHEMBL4155916) Binding affinity to human FLT3 ITD/F691L double mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_1754558 (CHEMBL4189318) Binding affinity to human partial length DNA-tagged BRD7 expressed in mammalian expression system by BROMOscan method
- ChEMBL_1754569 (CHEMBL4189329) Binding affinity to human partial length DNA-tagged PCAF expressed in mammalian expression system by BROMOscan method
- ChEMBL_1755143 (CHEMBL4189903) Binding affinity to DNA-tagged human partial length TrkA expressed in mammalian expression system by qPCR method
- ChEMBL_1755144 (CHEMBL4189904) Binding affinity to DNA-tagged human partial length AURKA expressed in mammalian expression system by qPCR method
- ChEMBL_1792071 (CHEMBL4263990) Inhibition of recombinant N-terminal GST-tagged human TGFbetaR2 expressed in Baculovirus expression system by LanthaScreen assay
- ChEMBL_1792693 (CHEMBL4264612) Inhibition of recombinant full length His-tagged human CDK7/cyclin H/MNAT1 expressed in baculovirus expression system
- ChEMBL_1803683 (CHEMBL4275975) Inhibition of human GST-tagged haspin expressed in baculovirus expression system in presence of 100 uM ATP
- ChEMBL_1815515 (CHEMBL4315089) Inhibition of recombinant human GST-tagged PDGFR alpha (550 to 1089 residues) expressed in baculovirus expression system
- ChEMBL_1826713 (CHEMBL4326587) Inhibition of human recombinant GST-tagged cytoplasmic MER (578 to 872 residues) expressed in baculovirus expression system
- ChEMBL_1826836 (CHEMBL4326710) Inhibition of human full-length GST-fused PTP1B expressed in bacterial expression system using pNPP as substrate
- ChEMBL_1881338 (CHEMBL4382837) Inhibition of recombinant full length GST-tagged human SLK expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_1882260 (CHEMBL4383759) Inhibition of recombinant human GST-tagged EGFR L858R mutant expressed in baculovirus expression system by fluorescence assay
- ChEMBL_1926283 (CHEMBL4429355) Downregulation of ER-alpha expression in human T47D cells measured after 5 days by Western blot analysis
- ChEMBL_1932659 (CHEMBL4478311) Binding affinity to human partial length FLT3 ITD mutant expressed in bacterial expression system after 1 hr
- ChEMBL_1934037 (CHEMBL4479689) Inhibition of full-length human His-tagged ABL1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934045 (CHEMBL4479697) Inhibition of full-length recombinant human His-tagged AURKB expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_1934053 (CHEMBL4479705) Inhibition of full-length recombinant human His-tagged CDK7 expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934058 (CHEMBL4479710) Inhibition of recombinant human His-tagged cytoplasmic CSF1R expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934059 (CHEMBL4479711) Inhibition of recombinant human GST-tagged cytoplasmic CSNK1A1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934061 (CHEMBL4479713) Inhibition of recombinant human GST-tagged DAPK1 catalytic domain expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934065 (CHEMBL4479717) Inhibition of recombinant human GST-tagged cytoplasmic EPHA8 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934066 (CHEMBL4479718) Inhibition of recombinant human GST-tagged cytoplasmic EPHB2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934067 (CHEMBL4479719) Inhibition of recombinant human His-tagged cytoplasmic ERBB2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934068 (CHEMBL4479720) Inhibition of recombinant human His-tagged cytoplasmic FGFR2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934069 (CHEMBL4479721) Inhibition of recombinant human His-tagged cytoplasmic FLT3 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934072 (CHEMBL4479724) Inhibition of full-length human GST-tagged GSK3A expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934085 (CHEMBL4479737) Inhibition of recombinant human His-tagged cytoplasmic KDR expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934086 (CHEMBL4479738) Inhibition of recombinant human His-tagged cytoplasmic KIT expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934088 (CHEMBL4479740) Inhibition of recombinant human GST-tagged LRRK2 catalytic domain expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934089 (CHEMBL4479741) Inhibition of full-length recombinant human His-tagged MAP2K1 expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_1934105 (CHEMBL4479757) Inhibition of recombinant human His-tagged cytoplasmic NTRK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934106 (CHEMBL4479758) Inhibition of recombinant human His-tagged cytoplasmic NTRK3 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934107 (CHEMBL4479759) Inhibition of full-length recombinant human His-tagged NUAK1 expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934128 (CHEMBL4479780) Inhibition of full-length recombinant human His-tagged SRC expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934134 (CHEMBL4479786) Inhibition of recombinant human GST-tagged cytoplasmic TEK expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1935754 (CHEMBL4481513) Binding affinity to human IRAK3 (147 to 596 residues) expressed in bacterial expression system by KINOMEscan assay
- ChEMBL_196627 (CHEMBL798017) Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.
- ChEMBL_197061 (CHEMBL807508) Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.
- ChEMBL_1972143 (CHEMBL4604961) Inhibition of recombinant human DYRK1A (129 to 509 residues) expressed in mammalian expression system by Kinomescan method
- ChEMBL_1972144 (CHEMBL4604962) Inhibition of recombinant human GSK3beta (1 to 433 residues) expressed in mammalian expression system by Kinomescan method
- ChEMBL_197220 (CHEMBL798968) Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.
- ChEMBL_1989199 (CHEMBL4622746) Agonist activity at human TLR7 overexpressed in HEK293 cells assessed as NFkappaB expression by reporter gene assay
- ChEMBL_1989200 (CHEMBL4622747) Agonist activity at human TLR8 overexpressed in HEK293 cells assessed as NFkappaB expression by reporter gene assay
- ChEMBL_1991908 (CHEMBL4625643) Inhibition of human wild type partial length TAK1 (1 to 303 residues) expressed in mammalian expression system
- ChEMBL_1991910 (CHEMBL4625645) Inhibition of human wild type partial length TYRO3 (497 to 814 residues) expressed in bacterial expression system
- ChEMBL_1991911 (CHEMBL4625646) Inhibition of human wild type partial length IRAK3 (147 to 596 residues) expressed in bacterial expression system
- ChEMBL_2014130 (CHEMBL4667708) Binding affinity to human wild type full-length ADCK3 expressed in bacterial expression system by Kinomescan method
- ChEMBL_2014138 (CHEMBL4667716) Binding affinity to wild-type human full length NLK expressed in bacterial expression system by Kinomescan method
- ChEMBL_2055589 (CHEMBL4710590) Binding affinity to wild type TTR (unknown origin) expressed in bacterial expression system by isothermal titration calorimetry
- ChEMBL_2101538 (CHEMBL4809934) Binding affinity to human partial length BRD2 BD 1 expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2105912 (CHEMBL4814587) Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assay
- ChEMBL_2108347 (CHEMBL4817022) Binding affinity to human wild type RIPK3 (M1/Q307) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2108348 (CHEMBL4817023) Binding affinity to human wild type RIPK1 (M1/K305) expressed in bacterial expression system by Kinomescan method
- ChEMBL_213813 (CHEMBL818858) In vitro inhibitory potency compared to PMA induced VCAM-1 expression in human endothelial cells (ELISA assay)
- ChEMBL_2198960 (CHEMBL5111476) Inhibition of full length human KDM5B expressed in baculovirus expression system using (ARTK(me3)QTARKSTGGKAPRKQLA peptide subst
- ChEMBL_2203500 (CHEMBL5116208) Inhibition of human recombinant GST tagged full length CLK4 expressed in Baculovirus expression system at 1 uM
- ChEMBL_2228702 (CHEMBL5142215) Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2228703 (CHEMBL5142216) Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2285703 Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by FRET assay
- ChEMBL_2336657 Inhibition of full length His-tagged METTL3 in baculovirus expression system (unknown origin) measured by mass spectrometric analysis
- ChEMBL_61628 (CHEMBL673084) In vitro binding affinity towards human Dopamine receptor D2L, using [3H]spiroperidol radioligand in Sf9 baculovirus expression.
- ChEMBL_624117 (CHEMBL1103448) Inhibition of human recombinant cathepsin S expressed in baculovirus expression sytem after 15 mins by FRET assay
- ChEMBL_665339 (CHEMBL1261016) Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system
- VDR Ligand-Binding Assay VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.
- ChEBML_1634511 Inhibition of human JAK3 JH1 catalytic domain (I781 to S1124 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEBML_1681140 Inhibition of recombinant human His-tagged CSF1R (538 to 910 residues) expressed in Baculovirus expression system by Z'Lyte assay
- ChEBML_1684757 Inhibition of N-terminal GST-tagged human HDAC11 expressed in baculovirus expression systemRHKAcKAc after 2 hrs by fluorescence assay
- ChEBML_1688534 Binding affinity to human wild type GCK (M1 to G318 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1465194 (CHEMBL3406078) Inhibition of BTK in human whole blood basophils assessed as inhibition of both anti-IgE-stimulated CD63 expression
- ChEMBL_1560208 (CHEMBL3778447) Inhibition of recombinant human GST-tagged CLK3 expressed in baculovirus expression system by lantha screen kinase binding assay
- ChEMBL_1573293 (CHEMBL3804025) Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISA
- ChEMBL_1582203 (CHEMBL3817429) Displacement of [3H]-TTNPB from RARalpha/RXRalpha (unknown origin) expressed in baculovirus expression system by scintillation proximity assay
- ChEMBL_1614096 (CHEMBL3855896) Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assay
- ChEMBL_1614097 (CHEMBL3855897) Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assay
- ChEMBL_1616863 (CHEMBL3858932) Inhibition of BTK in human peripheral B cells assessed as suppression of CD40/CD40L-stimulated CD69 surface expression
- ChEMBL_1627206 (CHEMBL3869727) Inhibition of human recombinant full length His-tagged CHK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1633246 (CHEMBL3876038) Inhibition of human recombinant His-tagged FLT3 cytoplasmic domain (564 to 958 residues) expressed in baculovirus expression system
- ChEMBL_1633249 (CHEMBL3876041) Inhibition of human recombinant His-tagged NTRK3 cytoplasmic domain (510 to 825 residues) expressed in baculovirus expression system
- ChEMBL_1633250 (CHEMBL3876042) Inhibition of human recombinant His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus expression system
- ChEMBL_1633251 (CHEMBL3876043) Inhibition of human recombinant His-tagged KIT cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system
- ChEMBL_1633255 (CHEMBL3876047) Inhibition of human recombinant His-tagged NTRK1 cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system
- ChEMBL_1633256 (CHEMBL3876048) Inhibition of human recombinant His-tagged FGFR2 cytoplasmic domain (403 to 822 residues) expressed in baculovirus expression system
- ChEMBL_1633259 (CHEMBL3876051) Inhibition of human recombinant full length C-terminal His-tagged SRC cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633262 (CHEMBL3876054) Inhibition of human recombinant full length C-terminal His-tagged LCK cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633263 (CHEMBL3876055) Inhibition of human recombinant GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system
- ChEMBL_1633264 (CHEMBL3876056) Inhibition of human recombinant GST-tagged TEK cytoplasmic domain (817 to 1101 residues) expressed in baculovirus expression system
- ChEMBL_1633267 (CHEMBL3876059) Inhibition of human recombinant GST-tagged INSR cytoplasmic domain (1011 to 1382 residues) expressed in baculovirus expression system
- ChEMBL_1633269 (CHEMBL3876061) Inhibition of human recombinant GST-tagged MAP3K8 catalytic domain (30 to 397 residues) expressed in baculovirus expression system
- ChEMBL_1633271 (CHEMBL3876063) Inhibition of human recombinant His-tagged KDR cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system
- ChEMBL_1633275 (CHEMBL3876067) Inhibition of human recombinant GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system
- ChEMBL_1633276 (CHEMBL3876068) Inhibition of human recombinant His-tagged ERBB2 cytoplasmic domain (676 to 1255 residues) expressed in baculovirus expression system
- ChEMBL_1633277 (CHEMBL3876069) Inhibition of human recombinant GST-tagged MINK1 catalytic domain (1 to 320 residues) expressed in baculovirus expression system
- ChEMBL_1633280 (CHEMBL3876072) Inhibition of human recombinant GST-tagged IRAK1 catalytic domain (194 to 712 residues) expressed in baculovirus expression system
- ChEMBL_1633283 (CHEMBL3876075) Inhibition of human recombinant full length N-terminal GST-tagged SYK cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1633285 (CHEMBL3876077) Inhibition of human recombinant His-tagged CDC42BPA catalytic domain (1 to 473 residues) expressed in baculovirus expression system
- ChEMBL_1633286 (CHEMBL3876078) Inhibition of human recombinant His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression system
- ChEMBL_1633292 (CHEMBL3876084) Inhibition of human recombinant GST-tagged EPHB2 cytoplasmic domain (616 to 884 residues) expressed in baculovirus expression system
- ChEMBL_1633297 (CHEMBL3876089) Inhibition of human recombinant GST-tagged JAK3 cytoplasmic domain (781 to 1124 residues) expressed in baculovirus expression system
- ChEMBL_1633304 (CHEMBL3876096) Inhibition of human recombinant GST-tagged ALK4 catalytic domain (150 to 505 residues) expressed in baculovirus expression system
- ChEMBL_1633310 (CHEMBL3876102) Inhibition of human recombinant GST-tagged EPHA8 cytoplasmic domain (565 to 1005 residues) expressed in baculovirus expression system
- ChEMBL_1633314 (CHEMBL3876106) Inhibition of human recombinant GST-tagged JAK1 cytoplasmic domain (866 to 1154 residues) expressed in baculovirus expression system
- ChEMBL_1633325 (CHEMBL3876117) Inhibition of human recombinant GST-tagged PASK catalytic domain (879 to 1323 residues) expressed in baculovirus expression system
- ChEMBL_1633335 (CHEMBL3876127) Inhibition of human recombinant GST-tagged ROCK1 cytoplasmic domain (1 to 535 residues) expressed in baculovirus expression system
- ChEMBL_1633337 (CHEMBL3876129) Inhibition of human recombinant GST-tagged RPS6KB1 cytoplasmic domain (1 to 421 residues) expressed in baculovirus expression system
- ChEMBL_1633338 (CHEMBL3876130) Inhibition of human recombinant GST-tagged SGK cytoplasmic domain (60 to 431 residues) expressed in baculovirus expression system
- ChEMBL_1633339 (CHEMBL3876131) Inhibition of human recombinant GST-tagged TAOK2 cytoplasmic domain (1 to 314 residues) expressed in baculovirus expression system
- ChEMBL_1653997 (CHEMBL4003363) Binding affinity to recombinant human CLK2 (D144 to R498 residues) expressed in bacterial expression system by KinomeScan assay
- ChEMBL_1658759 (CHEMBL4008371) Inhibition of full-length recombinant human His-tagged BTK expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1661463 (CHEMBL4011075) Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1661524 (CHEMBL4011136) Inhibition of recombinant human GST-tagged EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system
- ChEMBL_1661525 (CHEMBL4011137) Inhibition of recombinant human His-tagged EPHA3 cytoplasmic domain (569 to 976 residues) expressed in baculovirus expression system
- ChEMBL_1670381 (CHEMBL4020269) Binding affinity to human TAF1L (2) (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670382 (CHEMBL4020270) Binding affinity to human BRD8 (1) (S700 to F854 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1670389 (CHEMBL4020277) Binding affinity to human WDR9(2) (A1310 to E1430 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1686220 (CHEMBL4036699) Inhibition of recombinant human full length His-tagged BTK expressed in baculovirus expression system by Z-LYTE assay
- ChEMBL_1687837 (CHEMBL4038407) Inhibition of human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1687848 (CHEMBL4038418) Inhibition of human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750874 (CHEMBL4185634) Inhibition of recombinant full length His-tagged human Aurora A expressed in baculovirus expression system by Z'LYTE assay
- ChEMBL_1750875 (CHEMBL4185635) Inhibition of recombinant full length His-tagged human Aurora B expressed in baculovirus expression system by Z'LYTE assay
- ChEMBL_1750876 (CHEMBL4185636) Inhibition of recombinant full length GST-tagged human Aurora C expressed in baculovirus expression system by Z'LYTE assay
- ChEMBL_1771645 (CHEMBL4223757) Inhibition of BRD4-BD1 in human Raji cells assessed as downregulation of MYC gene expression by PCR method
- ChEMBL_1779811 (CHEMBL4236803) Inhibition of recombinant human full length His-tagged JNK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1779812 (CHEMBL4236804) Inhibition of recombinant human full length His-tagged JNK2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1797109 (CHEMBL4269226) Inhibition of recombinant C-terminal FLAG-tagged human GCN5 expressed in a Baculovirus-infected Sf9 cell expression system
- ChEMBL_1801591 (CHEMBL4273883) Binding affinity to recombinant human BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1821787 (CHEMBL4321447) Inhibition of BACE1 (unknown origin) expressed in baculovirus-expression system using Rh-EVNLDAEFK-Quencher substrate by FRET assay
- ChEMBL_1825571 (CHEMBL4325335) Inhibition of recombinant full-length human GST-tagged DYRK1A expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1825572 (CHEMBL4325336) Inhibition of recombinant full-length human GST-tagged DYRK1B expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1848558 (CHEMBL4349099) Inhibition of recombinant human full length His-tagged JNK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1848562 (CHEMBL4349103) Inhibition of recombinant human full length His-tagged JNK2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1848564 (CHEMBL4349105) Inhibition of recombinant human full length GST-tagged DYRK3 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1848568 (CHEMBL4349109) Inhibition of recombinant human full length His-tagged TSSK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1869627 (CHEMBL4370693) Inhibition of human recombinant P-TEFb expressed in baculovirus expression system after 10 mins by SDS-PAGE analysis
- ChEMBL_1881329 (CHEMBL4382828) Inhibition of recombinant His-tagged human ErbB2 cytoplasmic domain expressed in baculovirus expression system by Z-LYTE assay
- ChEMBL_1881333 (CHEMBL4382832) Inhibition of recombinant full length GST-tagged human FAK expressed in baculovirus expression system by Z-LYTE assay
- ChEMBL_1881337 (CHEMBL4382836) Inhibition of recombinant GST-tagged human ROS1 cytoplasmic domain expressed in baculovirus expression system by Z-LYTE assay
- ChEMBL_1905316 (CHEMBL4407674) Binding affinity to wild-type human partial length DDR1 (R565 to V876 residues) expressed in bacterial expression system
- ChEMBL_1926332 (CHEMBL4429404) Inhibition of BTK in human peripheral B cells assessed as suppression of CD40/CD40L stimulated CD69 surface expression
- ChEMBL_1927623 (CHEMBL4430695) Inhibition of full length recombinant human HDAC11 expressed in baculovirus expression system using fluorogenic substrate by fluorescence assay
- ChEMBL_1932663 (CHEMBL4478315) Binding affinity to human partial length FLT3 ITD/D835V mutant expressed in mammalian expression system after 1 hr
- ChEMBL_1932664 (CHEMBL4478316) Binding affinity to human partial length FLT3 ITD/F691L mutant expressed in mammalian expression system after 1 hr
- ChEMBL_1934038 (CHEMBL4479690) Inhibition of full-length recombinant human His-tagged ADRBK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934040 (CHEMBL4479692) Inhibition of full-length recombinant human His-tagged AKT2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934041 (CHEMBL4479693) Inhibition of full-length recombinant human His-tagged AKT3 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934042 (CHEMBL4479694) Inhibition of recombinant human GST-tagged ALK4 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934046 (CHEMBL4479698) Inhibition of full-length recombinant human His-tagged BMX expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934047 (CHEMBL4479699) Inhibition of full-length recombinant human GST-tagged BRAF expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934048 (CHEMBL4479700) Inhibition of full-length recombinant human His-tagged BTK expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934050 (CHEMBL4479702) Inhibition of recombinant human His-tagged CDC42BPA catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934051 (CHEMBL4479703) Inhibition of full-length recombinant human His-tagged CDK2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934055 (CHEMBL4479707) Inhibition of full-length recombinant human His-tagged CHEK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934056 (CHEMBL4479708) Inhibition of full-length recombinant human His-tagged CHEK2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934057 (CHEMBL4479709) Inhibition of recombinant human GST-tagged CLK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934060 (CHEMBL4479712) Inhibition of full-length recombinant human His-tagged CSNK2A1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934062 (CHEMBL4479714) Inhibition of full-length recombinant human GST-tagged DYRK1A expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934070 (CHEMBL4479722) Inhibition of full-length recombinant human GST-tagged GRK4 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934071 (CHEMBL4479723) Inhibition of full-length recombinant human GST-tagged GRK6 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934073 (CHEMBL4479725) Inhibition of full-length recombinant human His-tagged GSK3B expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934080 (CHEMBL4479732) Inhibition of full-length recombinant human His-tagged IRAK4 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934081 (CHEMBL4479733) Inhibition of full-length recombinant human GST-tagged ITK expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934084 (CHEMBL4479736) Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934087 (CHEMBL4479739) Inhibition of full-length recombinant human His-tagged LCK expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934090 (CHEMBL4479742) Inhibition of full-length recombinant human His-tagged MAP2K6 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934091 (CHEMBL4479743) Inhibition of recombinant human GST-tagged MAP3K8 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934093 (CHEMBL4479745) Inhibition of full-length recombinant human His-tagged MAPK13 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934095 (CHEMBL4479747) Inhibition of full-length recombinant human His-tagged MAPK8 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934096 (CHEMBL4479748) Inhibition of full-length recombinant human His-tagged MAPK9 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934098 (CHEMBL4479750) Inhibition of full-length recombinant human His-tagged MAPKAPK5 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934100 (CHEMBL4479752) Inhibition of recombinant human His-tagged MINK1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934101 (CHEMBL4479753) Inhibition of full-length recombinant human GST-tagged MST4 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934102 (CHEMBL4479754) Inhibition of full-length recombinant human His-tagged NEK2 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934103 (CHEMBL4479755) Inhibition of full-length recombinant human GST-tagged NEK4 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934108 (CHEMBL4479760) Inhibition of full-length recombinant human GST-tagged PAK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934109 (CHEMBL4479761) Inhibition of recombinant human GST-tagged PASK catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934110 (CHEMBL4479762) Inhibition of full-length recombinant human His-tagged PDK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934111 (CHEMBL4479763) Inhibition of full-length recombinant human His-tagged PIK3P110D/P85A expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934112 (CHEMBL4479764) Inhibition of full-length recombinant human His-tagged PIM1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934114 (CHEMBL4479766) Inhibition of full-length recombinant human GST-tagged PKN1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934115 (CHEMBL4479767) Inhibition of full-length recombinant human His-tagged PLK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934117 (CHEMBL4479769) Inhibition of full-length recombinant human His-tagged PRKCI expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934118 (CHEMBL4479770) Inhibition of full-length recombinant human His-tagged PRKCQ expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934120 (CHEMBL4479772) Inhibition of full-length recombinant human His-tagged PTK6 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934122 (CHEMBL4479774) Inhibition of recombinant human GST-tagged ROCK1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934124 (CHEMBL4479776) Inhibition of full-length recombinant human His-tagged RPS6KA3 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934126 (CHEMBL4479778) Inhibition of recombinant human GST-tagged SGK catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934129 (CHEMBL4479781) Inhibition of full-length recombinant human His-tagged SRPK1 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934130 (CHEMBL4479782) Inhibition of full-length recombinant human His-tagged STK22D expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934132 (CHEMBL4479784) Inhibition of recombinant human GST-tagged TAOK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_196907 (CHEMBL807369) Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alpha
- ChEMBL_1969952 (CHEMBL4602770) Inhibition of full length recombinant His-tagged human Glycogen synthase kinase-3 beta expressed in Baculovirus expression system
- ChEMBL_197076 (CHEMBL806664) Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-beta
- ChEMBL_197235 (CHEMBL801381) Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gamma
- ChEMBL_1988885 (CHEMBL4622432) Binding affinity to recombinant human CSF1R (564 to 939 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1988886 (CHEMBL4622433) Binding affinity to recombinant human FLT3 (592 to 969 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1988888 (CHEMBL4622435) Binding affinity to recombinant human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_1988889 (CHEMBL4622436) Binding affinity to recombinant human FLT3 ITD/F691L double mutant expressed in bacterial expression system by Kinomescan method
- ChEMBL_1988890 (CHEMBL4622437) Binding affinity to recombinant human KIT (571 to 972 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1988891 (CHEMBL4622438) Binding affinity to recombinant human PDGFRA (575 to 1002 residues) expressed in mammalian expression system by Kinomescan method
- ChEMBL_1988892 (CHEMBL4622439) Binding affinity to recombinant human PDGFRB (582 to 1009 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1988893 (CHEMBL4622440) Binding affinity to recombinant human RET (713 to 1014 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1989201 (CHEMBL4622748) Agonist activity at human TLR9 overexpressed in HEK-Blue cells assessed as NFkappaB expression by reporter gene assay
- ChEMBL_199700 (CHEMBL802928) In vitro inhibitory potency compared to IL1-beta induced Selectin E expression in human endothelial cells (ELISA assay)
- ChEMBL_199702 (CHEMBL803585) In vitro inhibitory potency compared to TNF-alpha induced Selectin E expression in human endothelial cells (ELISA assay)
- ChEMBL_2019294 (CHEMBL4672872) Inhibition of BTK in human peripheral B cells assessed as reduction in CD40/CD40L-induced CD86 surface expression
- ChEMBL_2022300 (CHEMBL4676113) Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha expression by Western blot analysis
- ChEMBL_2025450 (CHEMBL4679263) Inhibition of recombinant mouse sEH expressed in baculovirus expression system using MNPC as substrate by fluorescence-based assay
- ChEMBL_2025451 (CHEMBL4679264) Inhibition of recombinant rat sEH expressed in baculovirus expression system using MNPC as substrate by fluorescence-based assay
- ChEMBL_2025452 (CHEMBL4679265) Inhibition of recombinant human sEH expressed in baculovirus expression system using MNPC as substrate by fluorescence-based assay
- ChEMBL_2045344 (CHEMBL4700043) Inhibition of wild-type human ABL2 (A248 to G542 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2054760 (CHEMBL4709761) Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC as substrate by fluorometric assay
- ChEMBL_2090876 (CHEMBL4772139) Inhibition of mouse recombinant CLK1 expressed in bacterial expression system using GRSRSRSRSRSR as substrate by ADP-glo assay
- ChEMBL_2103830 (CHEMBL4812333) Inhibition of recombinant human N-terminal GST-tagged JAK1 (850 to 1154 residues) expressed in baculovirus expression system
- ChEMBL_2103832 (CHEMBL4812335) Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues) expressed in baculovirus expression system
- ChEMBL_2103835 (CHEMBL4812338) Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in baculovirus expression system
- ChEMBL_2103836 (CHEMBL4812339) Inhibition of recombinant human N-terminal GST-tagged TYK2 (871 to 1187 residues) expressed in baculovirus expression system
- ChEMBL_2116297 (CHEMBL4825238) Inhibition of human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2116299 (CHEMBL4825240) Inhibition of human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2116300 (CHEMBL4825241) Inhibition of human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2123515 (CHEMBL4832748) Inhibition of recombinant full-length human His-tagged PI3Kgamma expressed in baculovirus expression system by Selectscreen kinase assay
- ChEMBL_2124317 (CHEMBL4833550) Induction of CYP3A4 in human hepatocytes assessed as mRNA expression incubated for 3 days by RT-RTPCR analysis
- ChEMBL_2124318 (CHEMBL4833551) Induction of CYP2B6 in human hepatocytes assessed as mRNA expression incubated for 3 days by RT-RTPCR analysis
- ChEMBL_2127268 (CHEMBL4836613) Inhibition of recombinant human BRDT BD2 (250 to 382 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127269 (CHEMBL4836614) Inhibition of recombinant human BRDT BD1 (21 to 137 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127270 (CHEMBL4836615) Inhibition of recombinant human BRD4 BD2 (333 to 460 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127271 (CHEMBL4836616) Inhibition of recombinant human BRD4 BD1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127272 (CHEMBL4836617) Inhibition of recombinant human BRD3 BD2 (306 to 416 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127273 (CHEMBL4836618) Inhibition of recombinant human BRD2 BD2 (348 to 455 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127274 (CHEMBL4836619) Inhibition of recombinant human BRD3 BD1 (24 to 144 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127275 (CHEMBL4836620) Inhibition of recombinant human BRD2 BD1 (71 to 194 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2127455 (CHEMBL4836800) Binding affinity to human partial length FLT3 ITD mutant expressed in bacterial expression system by KdELECT Discover assay
- ChEMBL_213811 (CHEMBL818856) In vitro inhibitory potency compared to IL1-beta induced VCAM-1 expression in human endothelial cells (ELISA assay)
- ChEMBL_213815 (CHEMBL873907) In vitro inhibitory potency compared to TNF-alpha induced VCAM-1 expression in human endothelial cells (ELISA assay)
- ChEMBL_2198932 (CHEMBL5111448) Inhibition of human wild type TAOK1 (M1 to A320 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_2212961 (CHEMBL5125910) Inhibition of recombinant human BRD4-1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2212962 (CHEMBL5125911) Inhibition of recombinant human BRD4-2 (333 to 460 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2212964 (CHEMBL5125913) Inhibition of recombinant human BRDT-1 (21 to 137 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2212965 (CHEMBL5125914) Inhibition of recombinant human BRDT-2 (250 to 382 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2227364 (CHEMBL5140877) Inhibition of recombinant Pseudomonas aeruginosa LecB expressed in Escherichia coli BL21 (DE3) expression system by fluorescence polarization assay
- ChEMBL_2251913 (CHEMBL5166123) Binding affinity to human BRD4 BD1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2261551 (CHEMBL5216562) Inhibition of human recombinant ERalpha expressed in baculovirus expression system measured after 20 mins by fluorescent polarisation Assay
- ChEMBL_2261552 (CHEMBL5216563) Inhibition of human recombinant ERbeta expressed in baculovirus expression system measured after 20 mins by fluorescent polarisation Assay
- ChEMBL_2287563 Inhibition of GST/His-tagged human recombinant DDR2 N456S mutant (422 to 855 residues) expressed in baculovirus expression system
- ChEMBL_2301492 Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301493 Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301494 Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301495 Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301496 Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301507 Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_2301510 Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301514 Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301515 Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301516 Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301517 Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301518 Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301519 Binding affinity to human partial length FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301520 Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301523 Binding affinity to human partial length PCAF (G715 to D831 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301524 Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301525 Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301528 Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2301529 Binding affinity to human partial length TRIM33 (D882 to A1087 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2447318 Binding affinity to recombinant full-length Flag-tagged NSUN3 (unknown origin) expressed in baculovirus expression system by MST assay
- ChEMBL_2510979 Inhibition of domain-GST fused HGFR (unknown origin) expressing in an Sf9 infected baculovirus expression system by ELISA method
- ChEMBL_2525064 Inhibition of erbB in human MDA-MB-453 cells assessed as reduction in heregulin-stimulated pp62(c-fos) expression
- ChEMBL_596521 (CHEMBL1039009) Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay
- ChEMBL_621741 (CHEMBL1108473) Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy
- ChEMBL_699552 (CHEMBL1647910) Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assay
- ChEMBL_787482 (CHEMBL1919401) Antagonist activity against human CRTh2 receptor in human eosinophils assessed as inhibition of DK-PGD2-induced CD11b expression
- ChEMBL_794848 (CHEMBL1936031) Inhibition of human recombinant FAK expressed in baculovirus expression system after 30 mins by time resolved fluorescence assay
- ChEMBL_794849 (CHEMBL1936085) Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay
- ChEMBL_826390 (CHEMBL2049401) Inhibition of N-terminal 6xHis tagged Aurora B kinase expressed using baculovirus expression system using [gamma-33P]ATP
- ChEBML_1614093 Inhibition of human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assay
- ChEBML_1614094 Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assay
- ChEBML_1614095 Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assay
- ChEBML_1658778 Inhibition of human His-tagged NUDT15 expressed in bacterial expression system after 1 hr by malachite green reagent based assay
- ChEBML_1658779 Inhibition of human His-tagged ITPase expressed in bacterial expression system after 1 hr by malachite green reagent based assay
- ChEBML_1692380 Inhibition of GST-tagged human DDR1 catalytic domain (440 to 876 residues) expressed in baculovirus expression system by LanthaScreen assay
- ChEBML_1692381 Inhibition of GST-tagged human DDR2 cytoplasmic domain (427 to 855 residues) expressed in baculovirus expression system by LanthaScreen assay
- ChEBML_1692384 Inhibition of recombinant full length His-tagged human BMX cytoplasmic domain expressed in baculovirus expression system by Z'-Lyte assay
- ChEBML_1692385 Inhibition of recombinant full length His-tagged human BTK cytoplasmic domain expressed in baculovirus expression system by Z'-Lyte assay
- ChEMBL_1352458 (CHEMBL3270979) Inhibition of BTK in human tonsilar B cells assessed as inhibition of IL6 expression after 1 hr by EIA
- ChEMBL_1465195 (CHEMBL3406079) Inhibition of BTK in human whole blood B-cells assessed as inhibition of both anti-IgD-stimulated CD69 expression
- ChEMBL_1495662 (CHEMBL3578650) Inhibition of 2-deoxyglucose-induced GRP78 (unknown origin) expression transfected in human HT1080 cells by luciferase reporter gene assay
- ChEMBL_1506507 (CHEMBL3599973) Inhibition of HIF-2alpha in human Hep3B cells assessed as downregulation of EPO mRNA expression by RT-PCR analysis
- ChEMBL_1579229 (CHEMBL3812309) Inhibition of His-tagged recombinant human CSF1R expressed in baculovirus expression system after 1 hr by Z-lyte assay
- ChEMBL_1616868 (CHEMBL3858937) Inhibition of BTK in human whole blood basophils assessed as suppression of FceRI/anti-IgE-stimulated CD63 surface expression
- ChEMBL_1633266 (CHEMBL3876058) Inhibition of human recombinant GST-tagged JAK2 cytoplasmic domain (809 to 1153 +9 residues) expressed in baculovirus expression system
- ChEMBL_1656313 (CHEMBL4005783) Inhibition of human N-terminal His-tagged HER2 expressed in baculovirus expression system in presence of 1 mM ATP
- ChEMBL_1670376 (CHEMBL4020264) Binding affinity to human PBRM1 bromodamian-5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670380 (CHEMBL4020268) Binding affinity to human TRIM24 (PHD, Bromo) (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670388 (CHEMBL4020276) Binding affinity to human PBRM1 bromodomain-2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1670390 (CHEMBL4020278) Binding affinity to human TRIM33 (PHD, Bromo) (D882 to A1087 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1674679 (CHEMBL4024822) Binding affinity to recombinant human GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system
- ChEMBL_1674768 (CHEMBL4024911) Inhibition of PI3Kdelta in ACD-treated human whole blood assessed as reduction in CD69 expression measured after 1 hr
- ChEMBL_1678434 (CHEMBL4028577) Inhibition of recombinant human CYP3A4 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assay
- ChEMBL_1678435 (CHEMBL4028578) Inhibition of recombinant human CYP2D6 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assay
- ChEMBL_1678436 (CHEMBL4028579) Inhibition of recombinant human CYP2C19 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assay
- ChEMBL_1678437 (CHEMBL4028580) Inhibition of recombinant rat CYP3A1 expressed in baculosomes expression system using fluorogenic-BOMCC as substrate by fluorescent homogeneous assay
- ChEMBL_1679206 (CHEMBL4029483) Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_1681138 (CHEMBL4031415) Inhibition of full length recombinant human His-tagged CDK8/Cyclin C expressed in Baculovirus expression system by Z'Lyte assay
- ChEMBL_1683087 (CHEMBL4033364) Inhibition of GST-tagged human PAK4 (295 to 591 residues) expressed in Baculovirus expression system by Z'-Lyte assay
- ChEMBL_1684757 (CHEMBL4035236) Inhibition of N-terminal GST-tagged human HDAC11 expressed in baculovirus expression systemRHKAcKAc after 2 hrs by fluorescence assay
- ChEMBL_1707037 (CHEMBL4058270) Binding affinity to human DNA-tagged BRD7 (125 to 254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1709731 (CHEMBL4119780) Binding affinity to wild-type human PIK3Calpha (R108 to N1068 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1709732 (CHEMBL4119781) Binding affinity to wild-type human PIK3Cbeta (P118 to S1070 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1709733 (CHEMBL4119782) Binding affinity to wild-type human PIK3Cdelta (R108 to Q1044 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1709734 (CHEMBL4119783) Binding affinity to wild-type human PIK3Cgamma (S144 to A1102 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1709735 (CHEMBL4119784) Binding affinity to wild-type human MTOR (L1382 to W2549 residues) expressed in mammalian expression system by KINOMEScan assay
- ChEMBL_1709763 (CHEMBL4119812) Inhibition of recombinant human full length His-tagged PI3K p110gamma expressed in baculovirus expression system by TR-FRET assay
- ChEMBL_1735478 (CHEMBL4151014) Binding affinity to human BRD2 bromodomain 1 (K71 to N194 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735479 (CHEMBL4151015) Binding affinity to human BRD2 bromodomain 2 (E348 to D455 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735480 (CHEMBL4151016) Binding affinity to human BRD3 bromodomain 1 (P24 to E144 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735481 (CHEMBL4151017) Binding affinity to human BRD3 bromodomain 2 (G306 to P416 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735482 (CHEMBL4151018) Binding affinity to human BRD4 bromodomain 1 (N44 to E168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735483 (CHEMBL4151019) Binding affinity to human BRD4 bromodomain 2 (K333 to E460 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735484 (CHEMBL4151020) Binding affinity to human BRDT bromodomain 1 (N21 to E137 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735485 (CHEMBL4151021) Binding affinity to human BRDT bromodomain 2 (K250 to E382 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735502 (CHEMBL4151038) Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735503 (CHEMBL4151039) Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735507 (CHEMBL4151043) Binding affinity to human TAF1L bromodomain 2 (Q1523 to D1654 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735508 (CHEMBL4151044) Binding affinity to human TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOScan assay
- ChEMBL_1735510 (CHEMBL4151046) Binding affinity to human TRIM33-phd-bromo (D882 to A1087 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1735511 (CHEMBL4151047) Binding affinity to human WDR9 bromodomain 2 (A1310 to E1430 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1740164 (CHEMBL4155914) Binding affinity to human FLT3 D835Y mutant (Q580 to Y969 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1750685 (CHEMBL4185445) Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750686 (CHEMBL4185446) Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750687 (CHEMBL4185447) Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750688 (CHEMBL4185448) Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750689 (CHEMBL4185449) Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750690 (CHEMBL4185450) Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750691 (CHEMBL4185451) Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750692 (CHEMBL4185452) Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1750695 (CHEMBL4185455) Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750696 (CHEMBL4185456) Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750697 (CHEMBL4185457) Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750698 (CHEMBL4185458) Binding affinity to human partial length FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750699 (CHEMBL4185459) Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750702 (CHEMBL4185462) Binding affinity to human partial length PCAF (G715 to D831 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750703 (CHEMBL4185463) Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750704 (CHEMBL4185464) Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1750708 (CHEMBL4185468) Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751644 (CHEMBL4186404) Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751645 (CHEMBL4186405) Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751646 (CHEMBL4186406) Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751647 (CHEMBL4186407) Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751648 (CHEMBL4186408) Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751659 (CHEMBL4186419) Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1751662 (CHEMBL4186422) Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751666 (CHEMBL4186426) Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751667 (CHEMBL4186427) Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751668 (CHEMBL4186428) Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751669 (CHEMBL4186429) Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751670 (CHEMBL4186430) Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751671 (CHEMBL4186431) Binding affinity to human partial length FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751672 (CHEMBL4186432) Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751675 (CHEMBL4186435) Binding affinity to human partial length PCAF (G715 to D831 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751676 (CHEMBL4186436) Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751677 (CHEMBL4186437) Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751680 (CHEMBL4186440) Binding affinity to human partial length TRIM24 (G862 to E980 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751681 (CHEMBL4186441) Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1751682 (CHEMBL4186442) Binding affinity to human partial length TRIM33 (D882 to A1087 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1770602 (CHEMBL4222714) Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay
- ChEMBL_1775372 (CHEMBL4232364) Inhibition of recombinant human DPP4 expressed in baculovirus expression system using Ala-Pro-AMC as substrate by fluorometric analysis
- ChEMBL_1778486 (CHEMBL4235478) Binding affinity to partial length human BRAF (S429 to E741 residues) expressed in mammalian expression system by KdELECT assay
- ChEMBL_1778487 (CHEMBL4235479) Binding affinity to partial length human RAF1 (I330 to T640 residues) expressed in bacterial expression system by KdELECT assay
- ChEMBL_1778488 (CHEMBL4235480) Binding affinity to partial length human KIT (I571 to D952 residues) expressed in bacterial expression system by KdELECT assay
- ChEMBL_1778489 (CHEMBL4235481) Binding affinity to partial length human PDGFRA (V575 to D1002 residues) expressed in mammalian expression system by KdELECT assay
- ChEMBL_1778490 (CHEMBL4235482) Binding affinity to partial length human PDGFRB (V582 to Y1009 residues) expressed in bacterial expression system by KdELECT assay
- ChEMBL_1831097 (CHEMBL4331105) Binding affinity to human phosphorylated ABL1 Q252H mutant expressed in mammalian expression system after 60 mins by Kinomescan method
- ChEMBL_1832289 (CHEMBL4332297) Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISA
- ChEMBL_1832290 (CHEMBL4332298) Inhibition of human GST-fused HER2 kinase domain expressed in baculovirus expression system measured after 30 mins by ELISA
- ChEMBL_1858868 (CHEMBL4359597) Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1858869 (CHEMBL4359598) Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1858870 (CHEMBL4359599) Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1858871 (CHEMBL4359600) Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1858872 (CHEMBL4359601) Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1858873 (CHEMBL4359602) Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1858874 (CHEMBL4359603) Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1864565 (CHEMBL4365540) Inhibition of GST-tagged ERK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assay
- ChEMBL_1864566 (CHEMBL4365541) Inhibition of GST-tagged MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins by HTS assay
- ChEMBL_1867384 (CHEMBL4368359) Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1867385 (CHEMBL4368360) Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1881334 (CHEMBL4382833) Inhibition of recombinant GST/His-tagged human FER catalytic domain expressed in baculovirus expression system by Z-LYTE assay
- ChEMBL_1886871 (CHEMBL4388548) Binding affinity to human partial length EGFR S752-I759 deletion mutant expressed in bacterial expression system by KinomeScan assay
- ChEMBL_1886872 (CHEMBL4388549) Binding affinity to human partial length EGFR E746-A750 deletion mutant expressed in bacterial expression system by KinomeScan assay
- ChEMBL_1886873 (CHEMBL4388550) Binding affinity to human partial length EGFR L747-S752del/P753S mutant expressed in bacterial expression system by KinomeScan assay
- ChEMBL_1886875 (CHEMBL4388552) Binding affinity to human partial length EGFR L747-T751del/Sins mutant expressed in bacterial expression system by KinomeScan assay
- ChEMBL_1886876 (CHEMBL4388553) Binding affinity to human partial length EGFR L747-E749del/A750P mutant expressed in bacterial expression system by KinomeScan assay
- ChEMBL_1892621 (CHEMBL4394542) Binding affinity to wild-type human ABL2 (A248 to G542 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_1892625 (CHEMBL4394546) Binding affinity to wild-type human ABL1 (S229 to K512 residues) expressed in mammalian expression system by Kinomescan method
- ChEMBL_1899300 (CHEMBL4401415) Binding affinity to auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expression
- ChEMBL_1899770 (CHEMBL4401885) Binding affinity to human INSR (997 to 1318 residues) expressed in mammalian expression system by kinome scan-based assay
- ChEMBL_1899771 (CHEMBL4401886) Binding affinity to human PLK1 (33 to 325 residues) expressed in mammalian expression system by kinome scan-based assay
- ChEMBL_1899772 (CHEMBL4401887) Binding affinity to human PLK3 (42 to 334 residues) expressed in mammalian expression system by kinome scan-based assay
- ChEMBL_1910727 (CHEMBL4413173) Inhibition of recombinant full-length human His-tagged CDK8/cyclinC expressed in baculovirus expression system by Lantha screen assay
- ChEMBL_1934039 (CHEMBL4479691) Inhibition of full-length recombinant human His-tagged AKT1-alpha expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934054 (CHEMBL4479706) Inhibition of full-length recombinant human His-tagged CDK9/cyclin T1 expressed in baculovirus expression system by Adapta assay
- ChEMBL_1934074 (CHEMBL4479726) Inhibition of full-length human N-terminal GST-tagged HCK expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934076 (CHEMBL4479728) Inhibition of full-length recombinant human GST-tagged IKK-beta expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934077 (CHEMBL4479729) Inhibition of full-length recombinant human GST-tagged IKK-epsilon expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934121 (CHEMBL4479773) Inhibition of recombinant human GST-tagged RAF1 Y340D/Y341D mutant expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1934136 (CHEMBL4479788) Inhibition of full-length recombinant human His-tagged cytoplasmic ZAP70 expressed in baculovirus expression system by Z'-LYTE assay
- ChEMBL_1977812 (CHEMBL4610947) Inhibition of N-terminal His6-tagged Aurora B (1 to 403 residues) (unknown origin) expressed in baculovirus expression system
- ChEMBL_1977813 (CHEMBL4610948) Inhibition of N-terminal His6-tagged Aurora C (1 to 309 residues) (unknown origin) expressed in baculovirus expression system
- ChEMBL_1979357 (CHEMBL4612492) Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979358 (CHEMBL4612493) Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979359 (CHEMBL4612494) Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979360 (CHEMBL4612495) Binding affinity to human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979361 (CHEMBL4612496) Binding affinity to human partial length BRD1 (E556 to A688 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979362 (CHEMBL4612497) Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1979363 (CHEMBL4612498) Binding affinity to human partial length BRD8 BD1 (S700 to F854 residues) expressed in mammalian expression system BROMOscan assay
- ChEMBL_1979364 (CHEMBL4612499) Binding affinity to human partial length BRD8 BD2 (D1095 to F1235 residues) expressed in mammalian expression system BROMOscan assay
- ChEMBL_1979365 (CHEMBL4612500) Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979366 (CHEMBL4612501) Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979367 (CHEMBL4612502) Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979368 (CHEMBL4612503) Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979369 (CHEMBL4612504) Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979370 (CHEMBL4612505) Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979371 (CHEMBL4612506) Binding affinity to human partial length FALZ (S2791 to H2911 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979372 (CHEMBL4612507) Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979375 (CHEMBL4612510) Binding affinity to human partial length PCAF (G715 to D831 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979376 (CHEMBL4612511) Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979377 (CHEMBL4612512) Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1979380 (CHEMBL4612515) Binding affinity to human partial length TRIM24 (G862 to E980 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1982129 (CHEMBL4615391) Binding affinity to human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1982130 (CHEMBL4615392) Binding affinity to human partial length BRD7 (L125 to R254 residues) expressed in mammalian expression system by BROMOscan assay
- ChEMBL_1982131 (CHEMBL4615393) Binding affinity to human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_1983371 (CHEMBL4616777) Inhibition of BTK in human peripheral B cells assessed as reduction in CD69 surface expression by whole blood assay
- ChEMBL_1989322 (CHEMBL4623057) Inhibition of recombinant human N-terminal His6-tagged Aurora A expressed in baculovirus expression system by enzyme coupled assay
- ChEMBL_1989342 (CHEMBL4623077) Inhibition of recombinant human N-terminal His6-tagged Aurora B expressed in baculovirus expression system by enzyme coupled assay
- ChEMBL_2019293 (CHEMBL4672871) Inhibition of BTK in human peripheral B cells assessed as reduction in anti-IgM/IgG-induced CD86 surface expression
- ChEMBL_2032152 (CHEMBL4686310) Binding affinity to human partial length FLT3 ITD/F691L double mutant expressed in mammalian expression system by Kinomescan method
- ChEMBL_2035017 (CHEMBL4689175) Agonist activity at RORgammat in human Whole blood assessed as increase in IL17 expression after 48 hrs by AlphaLISA
- ChEMBL_2046395 (CHEMBL4701094) Binding affinity to human wild-type AAK1 (G25 to L333 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2046396 (CHEMBL4701095) Binding affinity to human wild-type BMP2K (S34 to N329 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2069584 (CHEMBL4724837) Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan method
- ChEMBL_2069585 (CHEMBL4724838) Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BROMOscan method
- ChEMBL_2070659 (CHEMBL4726193) Inhibition of His-tagged recombinant human TEC expressed in baculovirus expression system preincubated for 1 hr by Z'lyte assay
- ChEMBL_2071500 (CHEMBL4727034) Binding affinity to human partial length TRIM24 (P790 to P977 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2071501 (CHEMBL4727035) Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2071502 (CHEMBL4727036) Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2071529 (CHEMBL4727063) Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2090874 (CHEMBL4772137) Inhibition of human recombinant CDK5/p25 expressed in bacterial expression using histone H1 as substrate by ADP-glo assay
- ChEMBL_2090879 (CHEMBL4772142) Inhibition of recombinant human PIM1 expressed in bacterial expression system using histone H1 as substrate by ADP-glo assay
- ChEMBL_2115136 (CHEMBL4824077) Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BromoELECT assay
- ChEMBL_2115137 (CHEMBL4824078) Binding affinity to human partial length EP300 (A1040 to G1161 residues) expressed in bacterial expression system by BromoELECT assay
- ChEMBL_2116294 (CHEMBL4825235) Inhibition of human partial length BRD4 BD1 (N44 to E168 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2116296 (CHEMBL4825237) Inhibition of human partial length BRD4 BD2 (K333 to E460 residues) expressed in bacterial expression system by BROMOscan assay
- ChEMBL_2116298 (CHEMBL4825239) Inhibition of human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system measured by BROMOscan assay
- ChEMBL_2119196 (CHEMBL4828262) Inhibition of wild type human full length MKN1 (M1 to L424) expressed in mammalian expression system by HTRF method
- ChEMBL_2119602 (CHEMBL4828668) Inhibition of human wild type partial length STK16 (G11 to I305) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2127456 (CHEMBL4836801) Binding affinity to human partial length FLT3 ITD D835V mutant expressed in mammalian expression system by KdELECT Discover assay
- ChEMBL_2127457 (CHEMBL4836802) Binding affinity to human partial length FLT3 ITD F691L mutant expressed in mammalian expression system by KdELECT Discover assay
- ChEMBL_2127592 (CHEMBL4836937) Binding affinity to human partial length BCL2A1 (M1 to G153 residues) expressed in bacterial expression system by BCL2SCAN assay
- ChEMBL_2127594 (CHEMBL4836939) Binding affinity to human partial length BCLW (M1 to R171 residues) expressed in bacterial expression system by BCL2SCAN assay
- ChEMBL_2127601 (CHEMBL4836946) Binding affinity to human partial length MCL1 (D172N to R329 residues) expressed in bacterial expression system by BCL2SCAN assay
- ChEMBL_2127602 (CHEMBL4836947) Binding affinity to human partial length BCL2 (M1 to D211 residues) expressed in bacterial expression system by BCL2SCAN assay
- ChEMBL_2134337 (CHEMBL4843947) Inhibition of recombinant human GST-tagged JAK3 expressed in baculovirus expression system incubated for 1 hr by Z'lyte assay
- ChEMBL_2169140 (CHEMBL5054199) Inhibition of human full-length BMX (1 to 675 residues) expressed in baculovirus expression system by mobility shift assay
- ChEMBL_2185626 (CHEMBL5097708) Inhibition of cGAS expressed in human THP-1 cells assessed as reduction of IFN-beta expression by ELISA assay
- ChEMBL_2196502 (CHEMBL5109018) Binding affinity to human recombinant His-tagged full length ABL1 expressed in baculovirus expression system by TR-FRET assay
- ChEMBL_2203152 (CHEMBL5115860) Inhibition of human recombinant full length GST-tagged CDK4/Cyclin D1 expressed in Baculovirus expression system by Adapta assay
- ChEMBL_2203153 (CHEMBL5115861) Inhibition of human recombinant full length GST-tagged CDK6/Cyclin D1 expressed in Baculovirus expression system by Adapta assay
- ChEMBL_2203154 (CHEMBL5115862) Inhibition of human recombinant full length His-tagged CDK9/Cyclin T1 expressed in Baculovirus expression system by Adapta assay
- ChEMBL_2214142 (CHEMBL5127274) Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence assay
- ChEMBL_2214143 (CHEMBL5127275) Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence assay
- ChEMBL_2214144 (CHEMBL5127276) Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence assay
- ChEMBL_2214145 (CHEMBL5127277) Inhibition of PI3Kgamma (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence assay
- ChEMBL_2220406 (CHEMBL5133740) Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system by LanthaScreen assay
- ChEMBL_2228704 (CHEMBL5142217) Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2228705 (CHEMBL5142218) Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2250570 (CHEMBL5164780) Inhibition human wild type partial length Tie2 (N804 to T1112 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2251899 (CHEMBL5166109) Binding affinity to human partial length KIT (I571 to D952 residues) expressed in mammalian expression system by Kinomescan assay
- ChEMBL_2269376 Binding affinity to human partial length mTOR (L1382 to W2549 residues) expressed in mammalian expression system by KdELECT kinase assay
- ChEMBL_2269377 Binding affinity to human partial length Pim1 (A15 to K313 residues ) expressed in bacterial expression system by KdELECT kinase assay
- ChEMBL_2275290 Inhibition of STAT3 in human Hep3B cells assessed as inhibition of IL-6 stimulated STAT3 expression by luciferase reporter assay
- ChEMBL_2371983 Inhibition of JAK2/TYK2 signal transduction pathway in human whole blood assessed as reduction in IL-23 induced IFNalpha expression
- ChEMBL_2373256 Inhibition of human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system by KINOMEscan analysis
- ChEMBL_2373257 Inhibition of human partial length EGFR (R669 to G1022 residues) T790M mutant expressed in mammalian expression system by KINOMEscan analysis
- ChEMBL_2373261 Inhibition of human wild type partial length SLK (S14 to A307 residues) expressed in bacterial expression system by KINOMEscan analysis
- ChEMBL_2512834 Inhibition of recombinant human RIP3 kinase domain (1 to 328 residues) expressed in baculovirus expression system by fluorescence polarization assay
- ChEMBL_303805 (CHEMBL829854) Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells
- ChEMBL_510614 (CHEMBL1002261) Inhibition of glucocorticoid-mediated human MMP1 expression in PMA stimulated A549 cells assessed as MMP1 protein level by ELISA
- ChEMBL_536039 (CHEMBL991609) Activation of human GLP1R expressed in HEK293 cells assessed as effect on cAMP responsive element promoter driven luciferase expression
- ChEMBL_562894 (CHEMBL1018831) Activation of VDR in human THP1 cells assessed as increase in cathelicidin antimicrobial peptide mRNA expression by RT-PCR
- ChEMBL_851754 (CHEMBL2156222) Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis
- ChEMBL_89060 (CHEMBL698940) In vitro inhibitory potency compared to PMA induced Intercellular adhesion molecule-1 expression in human endothelial cells (ELISA assay)
- ChEMBL_1586204 (CHEMBL3819919) Inhibition of flag-tagged PTP1B (1 to 321 residues) (unknown origin) expressed in bacterial expression system by UV/Vis spectrophotometry
- ChEMBL_1669918 (CHEMBL4019806) Inhibition of LSD1 in human THP1 cells assessed as induction of CD86 expression after 48 hrs by flow cytometric analysis
- ChEMBL_1789548 (CHEMBL4261282) Binding affinity to DNA-tagged recombinant human ARK5 (25 to 332 residues) expressed in bacterial expression system by KINOMEscan assay
- ChEMBL_1789554 (CHEMBL4261288) Binding affinity to DNA-tagged recombinant human YSK4 (1019 to 1328 residues) expressed in mammalian expression system by KINOMEscan assay
- ChEMBL_1791712 (CHEMBL4263631) Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP
- ChEMBL_1791713 (CHEMBL4263632) Inhibition of recombinant full length human Dyrk1B expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP
- ChEMBL_1902852 (CHEMBL4405074) Binding affinity to human partial length BRD3 BD2 (G306 to P416 residues) expressed in bacterial expression system by bromoscan assay
- ChEMBL_2135420 (CHEMBL4845030) Inhibition of wild-type human partial length AURKB (D25 to A303 residues) expressed in mammalian expression system by Kinomescan method
- ChEMBL_2135421 (CHEMBL4845031) Inhibition of wild-type human full length PAK3 (M1 to R544 residues) expressed in bacterial expression system by Kinomescan method
- ChEMBL_2135422 (CHEMBL4845032) Inhibition of wild-type human partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian expression system by Kinomescan method
- ChEMBL_2152771 (CHEMBL5037318) Binding affinity to human partial length BRD3 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assay
- ChEMBL_2152772 (CHEMBL5037319) Binding affinity to human partial length BRDT BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assay
- ChEMBL_2169150 (CHEMBL5054209) Inhibition of BTK in human whole blood assessed as activation of anti-IgM-induced CD69 expression by flow cytometry analysis