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Query String: EGF

Carter, TA; Wodicka, LM; Shah, NP; Velasco, AM; Fabian, MA; Treiber, DK; Milanov, ZV; Atteridge, CE; Biggs, WH; Edeen, PT; Floyd, M; Ford, JM; Grotzfeld, RM; Herrgard, S; Insko, DE; Mehta, SA; Patel, HK; Pao, W; Sawyers, CL; Varmus, H; Zarrinkar, PP; Lockhart, DJ Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases. Proc Natl Acad Sci U S A 102: 11011-6 (2005)
Traxler, PM; Wacker, O; Bach, HL; Geissler, JF; Kump, W; Meyer, T; Regenass, U; Roesel, JL; Lydon, N Sulfonylbenzoyl-nitrostyrenes: potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase. J Med Chem 34: 2328-37 (1991)
Trinks, U; Buchdunger, E; Furet, P; Kump, W; Mett, H; Meyer, T; Müller, M; Regenass, U; Rihs, G; Lydon, N Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem 37: 1015-27 (1994)
Million, ME; Boiziau, J; Parker, F; Tocque, B; Roques, BP; Garbay, C Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives. J Med Chem 38: 4693-703 (1995)
Gazit, A; Osherov, N; Gilon, C; Levitzki, A Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem 39: 4905-11 (1996)
Gazit, A; Chen, J; App, H; McMahon, G; Hirth, P; Chen, I; Levitzki, A Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines. Bioorg Med Chem 4: 1203-7 (1996)
Traxler, PM; Furet, P; Mett, H; Buchdunger, E; Meyer, T; Lydon, N 4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem 39: 2285-92 (1996)
Peifer, C; Bühler, S; Hauser, D; Kinkel, K; Totzke, F; Schächtele, C; Laufer, S Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors. Eur J Med Chem 44: 1788-93 (2009)
Gazit, A; Osherov, N; Posner, I; Yaish, P; Poradosu, E; Gilon, C; Levitzki, A Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem 34: 1896-907 (1991)
Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem 40: 3601-16 (1997)
Liu, T; Shirai, R; Matsui, T; Umezawa, K; Iwasaki, S Synthesis and biological activity of 5-[(2,5-dihydroxybenzyl)amino]salicylic acid analogs as inhibitors of EGF receptor-associated protein tyrosine kinase Bioorg Med Chem Lett 7: 365-368 (1997)
Chen, H; Boiziau, J; Parker, F; Maroun, R; Tocque, B; Roques, BP; Garbay-Jaureguiberry, C Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity. J Med Chem 36: 4094-8 (1994)
Robinson, N; Gibson, TM; Chicarelli-Robinson, MI; Cameron, L; Hylands, PJ; Wilkinson, D; Simpson, TJ Cochliobolic acid, a novel metabolite produced by Cochliobolus lunatus, inhibits binding of TGF-alpha to the EGF receptor in a SPA assay. J Nat Prod 60: 6-8 (1997)
Myers, MR; Setzer, NN; Spada, A; Zulli, AL; Hsu, CJ; Zilberstein, A; Johnson, SE; Hook, LE; Jacoski, MV The preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity Bioorg Med Chem Lett 7: 417-420 (1997)
Chen, H; Boiziau, J; Parker, F; Mailliet, P; Commerçon, A; Tocque, B; Le Pecq, JB; Roques, BP; Garbay, C Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions. J Med Chem 37: 845-59 (1994)
Hennequin, LF; Ballard, P; Boyle, FT; Delouvrié, B; Ellston, RP; Halsall, CT; Harris, CS; Hudson, K; Kendrew, J; Pease, JE; Ross, HS; Smith, P; Vincent, JL Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: synthesis and structure-activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett 16: 2672-6 (2006)
Sun, L; Cui, J; Liang, C; Zhou, Y; Nematalla, A; Wang, X; Chen, H; Tang, C; Wei, J Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases. Bioorg Med Chem Lett 12: 2153-7 (2002)
Rewcastle, GW; Murray, DK; Elliott, WL; Fry, DW; Howard, CT; Nelson, JM; Roberts, BJ; Vincent, PW; Showalter, HD; Winters, RT; Denny, WA Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors. J Med Chem 41: 742-51 (1998)