ginsenoside-Rb1 BDBM50317541 Ginsenoside Rb1 CHEMBL501515
ginsenoside-Rb3 CHEMBL507688 BDBM50317540 ginsenoside Rb3
ginsenoside-Rd CHEMBL473659 Ginsenoside Rd BDBM50317539
CHEBI:77147 BDBM50023457 Ginsenoside Rh2 20(S)-Ginsenoside
BDBM50023447 Ginsenoside Rh1
BDBM50317538 CHEMBL1095007 Ginsenoside F2
CHEMBL1095004 BDBM50317544 Ginsenoside F3
Ginsenoside Rb2 CHEBI:77152 BDBM50450908
20(R)-Ginsenoside Rg2 CHEMBL1095006 BDBM50317542
20(S)-Ginsenoside Rg2 CHEMBL1095005 BDBM50317543
20(S)-ginsenoside Rg3 BDBM50317537 CHEMBL398412
CHEMBL1095008 BDBM50317536 20(R)-Ginsenoside Rg3
CHEMBL1783835 20(R)-Ginsenoside BDBM50023450 CVD-0019899
RC 160II BDBM84987
CAS_71306 RC 160 NSC_71306 BDBM82464 Vapreotide
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- ChEMBL_195662 (CHEMBL800046) Inhibitory effect on HIV-1 RT activity using template primer,poly (rC)-oligo (dG)
- ChEMBL_591809 (CHEMBL1041549) Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rC)-oligo)dG) as template
- ChEMBL_195664 (CHEMBL800048) Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rC)-oligo(dG) template primer
- ChEMBL_195671 (CHEMBL800744) Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template)
- ChEMBL_197278 (CHEMBL804265) Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primer
- ChEMBL_487140 (CHEMBL1022721) Inhibition of HIV1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rC)-oligo(dG) template
- ChEMBL_1855269 (CHEMBL4355998) Inhibition of Zika virus RNA-dependent RNA polymerase using poly(rC)/rG13 as substrate after 45 mins
- ChEMBL_195204 (CHEMBL798996) HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTP
- ChEBML_80619 Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP
- ChEMBL_886109 (CHEMBL2210031) Inhibition of HIV1 recombinant reverse transcriptase assessed as incorporation of biotin-dUTP into poly(rC)-oligo(dG) by colorimetric analysis
- ChEMBL_499472 (CHEMBL1018501) Inhibition of HIV1 recombinant reverse transcriptase assessed as incorporation of [32P]GTP into poly(rC).oligo(dG) (rCdG) homopolymer template primer
- ChEBML_80617 Inhibitory concentration against polymerization in A17 double mutant HIV-1 RT using a template primer of poly rC/dG12-18 and [3H]dGTP
- ChEMBL_195212 (CHEMBL800923) IC50 value was measured as RNA dependent DNA polymerase associated activity by using 10e-3 units of radiolabeled template poly(rC)-oligo(dG).
- ChEMBL_884996 (CHEMBL2211256) Inhibition of HIV1 reverse transcriptase assessed as biotin-dUTP incorporation into enzyme using poly(rC)-oligo(dG) as template primer by colorimetric analysis
- ChEMBL_195214 (CHEMBL800925) IC50 value was measured as RNA dependent DNA polymerase associated activity by using 1*10e-3 units of radiolabeled template poly(rC)-oligo(dG)
- ChEMBL_1294279 (CHEMBL3128956) Inhibition of wild type HIV-1 reverse transcriptase using poly (rC)/oligo (dG) as template/primer assessed as inhibition of biotin-dUTP incorporation after 1 hr by microtiter plate ELISA reader analysis
- HIV-1 RT Assay IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represents the mean of at least three determinations. The reproducibility of the assay was gauged using an internal standard.The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.
- Reverse Transcriptase Assay IC50 values for wild-type and mutant RTs were obtained from a scintillation proximity assay using poly rC/biotin-dG15 and 3H-dGTP. Each value represents the mean of at least three determinations. The reproducibility of the assay was gauged using an internal standard.The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.
- Primer-Dependent Transcription Assay IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcription assay. Following a 10 minute preincubation with the inhibitor, 20 nM of purified Con1b NS5B enzyme was incubated for 10 min. with 150 nM 5′-biotinylated oligo (rG13) primer, 15 nM poly(rC) template, 19 mM Tris-HCl, 5 mM MgCl2, 17 mM NaCl, 21 mM KCl, and 2.5 mM DTT. 600 nM GTP and 0.13 μCi of [3H]GTP was then added to initiate the 40-μl reaction mixture, which was then incubated at room temperature for 2 h before the reaction was stopped by addition of 40-μl streptavidin-coated SPA beads.
- Inhibition Assay Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synthesized RNA using heteropolymeric RNA template/primer. The RdRp assay was carried out in 384-well plates using 50 nM of purified NS5B enzyme, which was incubated with 300 nM 5'-biotinylated oligo(rG13)/poly(rC) or oligo (rU15)/poly(rA) primer-template, 600 nM of GTP, and 0.1 μCi of [3H]GTP or [3H]UTP in 25 mM Tris-HCl, pH 7.5, 5 mM MgCl2, 25 mM KCl, 17 mM NaCl and 3 mM of DTT. The 30 μL reaction mixture was incubated at room temperature for 2 h before stopping the reaction by adding 30 μL of streptavidin coated SPA-beads (GE Healthcare, Uppsala, Sweden) in 0.5 M EDTA. The 30 μL reaction was terminated after 2 hours at 25° C. upon addition of 30 μl streptavidin-coated SPA beads (GE Healthcare, Uppsala, Sweden 5 mg/ml in 0.5 M EDTA). After incubation at 25° C. for 30 min, the plate was counted using a Packard TopCount microplate reader (30 sec/well, 1 min count delay) and IC50 values were calculated (Table 1: IC50 1bJ4).
- Viral titer plaque assay Vero-E6 cells were seeded at 4 x 10E5 cells/well in 12-well plates and infected for 1 hour with the SARS-CoV-2 isolate USA-WA1/2020 at an MOI of 0.01. The cells were washed twice to remove residual unattached virus. Serial dilutions of each compound (0.1% DMSO in 2% FBS in DMEM media) were added to the cells and incubated at 37 °C (2 dpi). After 2 dpi, the supernatant containing virus was cleared from cell debris at 1000 rpm for 10 min and frozen until analysis via plaque assay. For the plaque assay, Vero-E6 cells were seeded at 7.5 x 10E5 cells/well in 6-well plates. The following day, the media was removed and replaced with 100 μL of 10-fold serial dilutions of previously frozen viral supernatant. Plates were incubated at 37°C for 1 hour with gentle rocking. Subsequently, overlay media (DMEM, 2% FBS, 0.6% Avicel RC-581) was added to each well. At 2 dpi for SARS-CoV-2 plates were fixed with 10% formaldehyde for 30 min, stained with crystal violet solution (0.5% crystal violet in 20% ethanol) for 30 min, and then rinsed with deionized water to visualize plaques.
- Cellular Assay-Influenza Virus Replication PR8 and X31 in Calu-3 Human Bronchial Epithelial Cells The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as described by Beaulieu A. et al. J Virol. 2013 April; 87(8):4237-51.Calu-3 cells were washed with Dulbecco's phosphate-buffered saline (D-PBS) and exposed to influenza virus (diluted in incomplete medium; 0.2% bovine serum albumin [BSA] instead of FBS). After virus adsorption (1 h at 37° C.), cells were washed once with D-PBS, and cells were incubated in incomplete culture medium containing increasing concentrations of the tested compound for 48 h.Viral titers were determined in the supernatants of infected cells by viral plaque assays as described by Cloutier et al. J Infect Dis. 2012 Feb. 15; 205(4):621-30. Serial 10-fold dilutions of clarified supernatants were prepared in incomplete Eagle's minimal essential medium (EMEM) (containing 0.1% bovine serum albumin instead of fetal bovine serum) and were titered on Madin-Darby canine kidney (MDCK) cells according to standard viral plaque assays. Confluent MDCK cells were exposed to lung supernatant dilutions for 1 hour to allow virus adsorption. Cells were then washed, and a semifluid medium containing Avicel RC-581 (FMC BioPolymer), incomplete EMEM, and 1 μg/mL Tosyl phenylalanyl chloromethyl ketone (TPCK)-treated trypsin (Sigma-Aldrich) was added to the cells. Cells were incubated for 48 hours, and viral plaques were revealed with 2% crystal violet after Carnoy fixation.