Simple Search Results

Query String: Lyn KO

CHEMBL1159714 Ko 707 BDBM50421719
3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butyl ester BDBM50305083 3-((3S,6S,12aS)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-propionic acid tert-butyl ester Ko143 Ko-143 US9695174, Ko143 CHEMBL488910

Miyano, N; Kinoshita, T; Nakai, R; Kirii, Y; Yokota, K; Tada, T Structural basis for the inhibitor recognition of human Lyn kinase domain. Bioorg Med Chem Lett 19: 6557-60 (2009)
Horio, T; Hamasaki, T; Inoue, T; Wakayama, T; Itou, S; Naito, H; Asaki, T; Hayase, H; Niwa, T Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives. Bioorg Med Chem Lett 17: 2712-7 (2007)
Dolan, BM; Duron, SG; Campbell, DA; Vollrath, B; Shankaranarayana Rao, BS; Ko, HY; Lin, GG; Govindarajan, A; Choi, SY; Tonegawa, S Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A 110: 5671-6
Kohal, R; Bhavana, na; Kumari, P; Sharma, AK; Gupta, GD; Verma, SK Fyn, Blk, and Lyn kinase inhibitors: A mini-review on medicinal attributes, research progress, and future insights. Bioorg Med Chem Lett 102:
Fallacara, AL; Passannanti, R; Mori, M; Iovenitti, G; Musumeci, F; Greco, C; Crespan, E; Kissova, M; Maga, G; Tarantelli, C; Spriano, F; Gaudio, E; Bertoni, F; Botta, M; Schenone, S Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. Eur J Med Chem 181: (2019)
Lipinski, CA; Reaume, AG High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept. Bioorg Med Chem 28: (2020)