US9617225, Roscovitine CHEMBL52387 BDBM7585 2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol 2,6,9-Trisubstituted purine deriv. 27 US10294218, Example Roscovitine (R,S)-Roscovitine
BDBM10910 (2R)-2-{[6-(benzyloxy)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol O6-(R)-roscovitine R-2-(6-Benzyloxy-9-isopropyl-9H-purin-2-yl-amino)-butan-1-ol
R-2-[6-(Benzyl-methyl-amino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol (2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)butan-1-ol BDBM10909 N6-methyl-(R)-roscovitine
(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol (R)-Roscovitine CYC-202 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol cid_160355 (2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol (2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol BDBM7533 Roscovitine (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol 2,6,9-Trisubstituted purine deriv. 28 CHEMBL14762
- Dolecková, I; Cesnek, M; Dracinský, M; Brynda, J; Voller, J; Janeba, Z; Kryštof, V Synthesis and biological evaluation of guanidino analogues of roscovitine. Eur J Med Chem 62: 443-52 (2013)
- Tang, L; Li, MH; Cao, P; Wang, F; Chang, WR; Bach, S; Reinhardt, J; Ferandin, Y; Galons, H; Wan, Y; Gray, N; Meijer, L; Jiang, T; Liang, DC Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem 280: 31220-9 (2005)
- Demange, L; Abdellah, FN; Lozach, O; Ferandin, Y; Gresh, N; Meijer, L; Galons, H Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling. Bioorg Med Chem Lett 23: 125-31 (2012)
- Oumata, N; Bettayeb, K; Ferandin, Y; Demange, L; Lopez-Giral, A; Goddard, ML; Myrianthopoulos, V; Mikros, E; Flajolet, M; Greengard, P; Meijer, L; Galons, H Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem 51: 5229-42 (2008)
- In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).
- Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. J Med Chem 52: 655-63 (2009)
- Jorda, R; Havlícek, L; McNae, IW; Walkinshaw, MD; Voller, J; Sturc, A; Navrátilová, J; Kuzma, M; Mistrík, M; Bártek, J; Strnad, M; Krystof, V Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. J Med Chem 54: 2980-93 (2011)
- MacCallum, DE; Melville, J; Frame, S; Watt, K; Anderson, S; Gianella-Borradori, A; Lane, DP; Green, SR Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res 65: 5399-407 (2005)