Query String: VP3 protein
- protein ssx2/protein ssxt
- penicillin-binding protein, transpeptidase domain protein
- protein kinase c inhibitor protein 1
- protein nef/tyrosine-protein kinase hck
- sensor protein kinase walk family protein
- tyrosine-protein kinase transforming protein src ITC
- dna damage-binding protein 1/protein cereblon
- pex5-related protein/peroxisomal membrane protein pex14
- tryptophan-rich sensory protein/translocator protein (tspo)
- tumor protein p53-inducible nuclear protein 2
- histone-binding protein rbbp4/histone-lysine n-methyltransferase ezh1/polycomb protein eed/polycomb protein suz12/zinc finger protein aebp2
- histone-binding protein rbbp4/histone-lysine n-methyltransferase ezh2/polycomb protein eed/polycomb protein suz12/zinc finger protein aebp2
- adora3 protein
- adra1b protein
- agtr1.2 protein
- avpr1a protein
- cad protein
- capsid protein
- ccr2 protein
- chrm4 protein
- core protein
- fabp3 protein
- glpg protein
- glra1 protein
- grik1 protein
- grik4 protein
- hd protein
- hdac5 protein
- hrh1 protein
- hrh3 protein
- jak1 protein
- kcnh2 protein
- kiaa0999 protein
- leader protein
- ncoa2 protein
- npy2r protein
- ns3 protein
- ns5b protein
- orf1a protein
- peplomer protein
- ppp5c protein
- prion protein
- protein c
- protein cab1
- protein cereblon
- protein dra
- protein e6
- protein enl
- protein farnesyltransferase
- protein g7a
- protein g9a
- protein grs
- protein gt197
- protein hunk1
- protein n
- protein p
- protein p63
- protein reca
- protein vp0
- rac1 protein
- sglt1 protein
- syk protein
- ultraspiracle protein
- uncharacterized protein
- zipper protein
- atr-interacting protein/serine/threonine-protein kinase atr
- breakpoint cluster region protein/tyrosine-protein kinase abl1
- rho-associated protein kinase 2/transforming protein rhoa
- dna damage-binding protein 1/protein cereblon [40-442]
- e3 ubiquitin-protein ligase mdm2 (p53-binding protein mdm2)
- multidrug resistance protein 1/multidrug resistance associated protein 1
- protein-glutamine gamma-glutamyltransferase 2/tyrosine-protein kinase jak3
- receptor protein-tyrosine kinase/serine/threonine-protein kinase mtor
- transforming protein rhoa/rho-related gtp-binding protein rhoc
- tyrosine-protein kinase abl1 [t315i]/breakpoint cluster region protein
- [tau protein] kinase
- acetylcholine binding protein
- adc-14 protein
- adc-16 protein
- adc-18 protein
- ah-related protein
- all1-related protein
- amiloride-binding protein
- aureobasidin-resistance protein
- bcl-2 protein
- bifunctional protein (glmu)
- bifunctional protein glmu
- bifunctional protein ncoat
- biotin--protein ligase
- bira bifunctional protein
- capsid scaffolding protein
- cd45-associated protein
- creb-binding protein
- er protein 57
- er protein 70
- erythromycin resistance protein
- fibroblast activation protein
- gcn2-like protein
- gim-1 protein
- glucokinase regulatory protein
- hdm2-p53 protein
- heterochromatin protein p25
- hypothetical protein sa1422
- integrin-associated protein
- isoquinoline-binding protein
- kir1 channel protein
- large structural protein
- lysosomal protective protein
- major excreted protein
- major prion protein
- matrix protein 2
- modifier 2 protein
- mok protein kinase
- myotonin-protein kinase
- nonstructural protein 3
- nonstructural protein 5
- nrf2-keap1 protein
- ns3/4a protein
- penicillin-binding protein
- phosphotyrosine protein phosphatase
- polymerase acidic protein
- ppar delta protein
- precursor membrane protein
- protein ayu17-449
- protein bfl-1
- protein brahma homolog
- protein farnesyltransferase (pft)
- protein hin-2
- protein kinase a
- protein kinase b
- protein kinase c
- protein kinase g
- protein kinase k35
- protein kinase pfmrk
- protein kinase sty
- protein mig-5
- protein polybromo-1
- protein prune homolog
- protein s100-a9
- protein uog-1
- protein wnt-3a
- protein yorkie homolog
- protein-tyrosine-phosphatase
- pup--protein ligase
- regulatory protein e2
- retinol-binding protein
- reverse transcriptase protein
- riboflavin-binding protein
- ring3-like protein
- sir2-like protein
- small g protein
- sortase family protein
- sporulation protein outb
- structural capsid protein
- survival protein a
- tax helper protein
- tegument protein vp16
- transactivating regulatory protein
- tyrosine-protein kinase
- vp1 capsid protein
- xiap protein bir2
- yersiniabactin biosynthetic protein
- zn finger protein
- dna-dependent protein kinase catalytic subunit/tyrosine-protein kinase abl1
- e3 ubiquitin-protein ligase cbl-b/tyrosine-protein kinase lck
- mitogen-activated protein kinase kinase kinase 7 interacting protein 1
- endoplasmin/heat shock protein 75/heat shock protein hsp 90-alpha/heat shock protein hsp 90-beta
- histone-binding protein rbbp4/histone-lysine n-methyltransferase ezh2/polycomb protein eed [40-441]/polycomb protein suz12
- myeloid/lymphoid or mixed-lineage leukemia protein 1 and wd repeat-containing protein 5 (mll1-wdr5) protein
- cell division cycle 7-related protein kinase/protein dbf4 homolog a
- coiled-coil domain-containing protein 6/tyrosine-protein kinase receptor ret
- e3 ubiquitin-protein ligase cbl-c and tyrosine-protein kinase lck
- e3 ubiquitin-protein ligase mdm2 [2-188]/protein mdm4 [2-185]
- kinesin-like protein kif15 and targeting protein for tpx2 (kif15/tpx2)
- mitogen-activated protein kinase 14/map kinase-activated protein kinase 5
- protein-glutamine gamma-glutamyltransferase 2/receptor-type tyrosine-protein phosphatase eta
- proto-oncogene tyrosine-protein kinase src/serine/threonine-protein kinase mtor
- 39 kda synovial protein
- 5-lipoxygenase activating protein
- acyl-protein thioesterase 1
- adenomatous polyposis coli protein
- alpha-fucosidase-like protein
- amiloride-binding protein 1
- amyloid-beta precursor protein
- ash2-like protein (ash2l)
- ataxin-3-like protein
- b-raf protein kinase
- bacterial penicillin-binding protein
- bcr/abl fusion protein
- beta-amyloid protein 40
- beta-amyloid protein 42
- biofilm regulatory protein a
- biotin protein ligase (bpl)
- bone morphogenetic protein 2
- bone morphogenetic protein 4
- brain digoxin carrier protein
- breakpoint cluster region protein
- bromodomain-containing protein 1
- bromodomain-containing protein 2
- bromodomain-containing protein 3
- bromodomain-containing protein 4
- bromodomain-containing protein 9
- calcium dependent protein kinase
- camp-dependent protein kinase
- cell division protein ftsz
- centromere-associated protein e
- cgmp-dependent protein kinase
- chloride channel protein 1
- cholesteryl ester transfer protein
- chromodomain y-like protein
- cn-iii-like protein
- collagen-binding protein 1
- cyclic amp receptor protein
- dcn1-like protein 1
- dead box protein retinoblastoma
- deah box protein 15
- deah box protein 29
- deah box protein 32
- deah box protein 33
- deah box protein 35
- deah box protein 40
- dna repair protein rev1
- drug resistance protein 1
- drug resistance protein 2
- dynamin-1-like protein
- ecdysone receptor/protein ultraspiracle
- ecdysone receptor/ultraspiracle protein
- eml4 alk fusion protein
- fibroblast activation protein (fap)
- fk506 binding protein 12
- fk506-binding protein 1a
- fk506-binding protein 5
- fmn_red domain-containing protein
- frequenin-like ubiquitous protein
- g protein-coupled receptor
- g-protein coupled receptor
- g25k gtp-binding protein
- g_protein_recep_f1_2 domain-containing protein
- glutamine cyclotransferase-related protein
- glutathione-binding protein (gbpaap)
- glutathione-binding protein (gbpahp)
- glutathione-binding protein (gbpapm)
- gtp-binding protein (rab7)
- heat shock protein 90
- heat shock protein hsp90
- heme-binding protein a
- heme-binding protein hutz
- histidine protein kinase ndkb
- histone deacetylase-related protein
- hnrnp core protein a1
- homologous to alr protein
- inositol-requiring protein 1
- inositol-requiring protein 2
- iron-starvation protein piga
- isochorismatase domain-containing protein
- kallikrein-like protein 2
- kallikrein-like protein 4
- kallikrein-like protein 5
- kelch-like protein 19
- kinesin spindle protein eg5
- kinesin-like protein 2
- kinesin-like protein kif18a
- lipid transfer protein i
- lymphocyte alpha-protein kinase
- lymphocyte pore-forming protein
- lysophospholipase-like protein 1
- macrophage gene 1 protein
- macrophage-stimulating protein receptor
- major capsid protein l1
- meningioma-associated protein 30
- methyltransferase-like protein 14
- microsomal triglyceride transfer protein
- microtubule-associated protein 2
- microtubule-associated protein tau
- mitogen-activated protein kinase
- mitotic chromosome-associated protein
- mrp-like protein 2
- multidrug efflux system protein
- multidrug resistance protein 1
- multidrug resistance protein cdr2
- nad-dependent protein deacetylase
- non-structural protein 1
- non-structural protein 11
- non-structural protein 3
- non-structural protein 4
- non-structural protein 4a
- non-structural protein 4b
- nonstructural protein ns3-4a
- numa-binding protein 1
- odorant-binding protein 6
- oxysterol-binding protein 2
- p53-binding protein hdmx
- p53-binding protein mdm2
- palmitoleoyl-protein carboxylesterase notum
- palmitoyl-protein hydrolase 1
- palmitoylated ev membrane protein
- penicillin binding protein 2'
- penicillin-binding protein 1
- penicillin-binding protein 2b
- penicillin-binding protein 3 ITC
- penicillin-binding protein 4 ITC
- penicillin-binding protein 5
- penicillin-binding protein c
- phd finger protein 1
- phd finger protein 2
- phd finger protein 8
- po66 carbohydrate-binding protein
- polyprenyl synthetase family protein
- prolyl oligopeptidase family protein
- protein cloroplastos alterados 1
- protein farnesyl/geranylgeranyl transferase
- protein kinase c (pkc)
- protein kinase c beta
- protein kinase c delta
- protein kinase c eta
- protein kinase c, alpha
- protein kinase c, zeta
- protein kinase ck2 (ck2 +-)
- protein microtubule organization 1
- protein phosphatase 5 (pp5)
- protein phosphatase methylesterase 1
- protein spinster homolog 2
- protein-tyrosine kinase cyl
- protein-tyrosine phosphatase 1d
- protein-tyrosine phosphatase alpha
- protein-tyrosine phosphatase meg2
- proton channel protein m2
- putative uncharacterized protein pk7
- quinolone resistance protein nora
- rar-responsive protein tig3
- receptor protein-tyrosine kinase
- redox-regulatory protein fam213a
- retinol-binding protein 4
- rho-associated protein kinase
- rhomboid domain-containing protein
- rhomboid-related protein 1
- ribosomal protein s6 kinase
- ring finger protein 56
- secreted protein-tyrosine phosphatase
- sensor protein kinase walk
- serine/threonine-protein kinase
- serine/threonine-protein phosphatase
- serotonin transporter protein (sert)
- signal transduction protein trap
- srsf protein kinase 1
- srsf protein kinase 2
- srsf protein kinase 3
- ssh-like protein 2
- sterol carrier protein 2
- sterol carrier protein-2
- surfeit locus protein 1
- telomerase protein component 1
- testicular protein kinase 2
- testis-expressed protein 17
- tpr/met fusion protein
- trans-activator protein bzlf1
- transcription regulatory protein gal11
- transcriptional activator protein trar
- transforming protein n-ras
- tubulin polymerization-promoting protein
- tyrosine-protein kinase (btk)
- tyrosine-protein kinase abl1
- tyrosine-protein kinase abl2
- tyrosine-protein kinase blk
- tyrosine-protein kinase brk
- tyrosine-protein kinase btk
- tyrosine-protein kinase cak
- tyrosine-protein kinase csk
- tyrosine-protein kinase ctk
- tyrosine-protein kinase fer
- tyrosine-protein kinase fes
- tyrosine-protein kinase fgr
- tyrosine-protein kinase fyn
- tyrosine-protein kinase itk
- tyrosine-protein kinase jak1
- tyrosine-protein kinase jak2
- tyrosine-protein kinase jak3
- tyrosine-protein kinase kit
- tyrosine-protein kinase lck
- tyrosine-protein kinase lyn
- tyrosine-protein kinase mer
- tyrosine-protein kinase receptor
- tyrosine-protein kinase sgk269
- tyrosine-protein kinase sky
- tyrosine-protein kinase src
- tyrosine-protein kinase srms
- tyrosine-protein kinase syk
- tyrosine-protein kinase tec
- tyrosine-protein kinase txk
- tyrosine-protein kinase tyk2
- tyrosine-specific protein kinase
- valosin-containing protein (vcp)
- viral protein genome-linked
- vitamin d-binding protein
- yersiniabactin siderophore biosynthetic protein
- zinc finger protein 51
- zinc finger protein gli1
- zinc finger protein gli2
- zinc finger protein sall4
- dna-dependent protein kinase catalytic subunit/proto-oncogene tyrosine-protein kinase src
- mitogen-activated protein kinase 10/receptor-interacting serine/threonine-protein kinase 1
- neurogenic locus notch homolog protein 3/recombining binding protein suppressor of hairless
- protein arginine n-methyltransferase 5 (prmt5) and methylosome protein wdr77 (mep-50)
- 5'-amp-activated protein kinase subunit beta-1/5'-amp-activated protein kinase subunit gamma-1/dual specificity protein kinase clk2
- bifunctional purine biosynthesis protein atic/thymidylate synthase/trifunctional purine biosynthetic protein adenosine-3
- mitogen-activated protein kinase kinase kinase 1/serine/threonine-protein kinase b-raf
- polymerase acidic protein/polymerase basic protein 2/rna-directed rna polymerase catalytic subunit
- proto-oncogene tyrosine-protein kinase receptor ret /nuclear receptor coactivator 4 fusion protein
- raf proto-oncogene serine/threonine-protein kinase/serine/threonine-protein kinase b-raf
- epidermal growth factor receptor/receptor tyrosine-protein kinase erbb-2/receptor tyrosine-protein kinase erbb-3/receptor tyrosine-protein kinase erbb-4
- 14-3-3 protein gamma
- 32 kda thylakoid membrane protein
- 5-hydroxytryptamine receptor 4 protein
- acetyl-coa transferase-like protein
- acetylcholine receptor protein delta chain
- acetylcholine-binding protein (ls-achbp)
- acyl-protein thioesterase 1 [i75l]
- acyl-protein thioesterase 1 [q83p]
- acyl-protein thioesterase 2 [h152r]
- acyl-protein thioesterase 2 [p86q]
- acyl-protein thioesterase 2 [s122a]
- bcr/abl fusion protein (t351i)
- bira bifunctional protein mutant (v214a)
- bira bifunctional protein mutant (v219a)
- bira bifunctional protein mutant (w223a)
- bromodomain protein 4 (brd4-bd1)
- bromodomain-containing protein 2 (brd2)
- calcium-dependent protein kinase 1
- calmodulin-domain protein kinase (cdpk1)
- calmodulin-domain protein kinase 1
- camp-dependent protein kinase (pka)
- cell cycle checkpoint protein rad1
- cholesterol-regulated 39 kda protein
- cyclin-dependent protein kinase h
- cyclin-dependent protein kinase pho85
- dedicator of cytokinesis protein 5
- dual specificity protein kinase (ttk)
- dual specificity protein kinase clk1
- dual specificity protein kinase clk3
- dual specificity protein phosphatase 5
- e3 ubiquitin-protein ligase mdm2
- e3 ubiquitin-protein ligase smurf1
- e3 ubiquitin-protein ligase smurf2
- e3 ubiquitin-protein ligase xiap
- elav-like protein 1 [i180a]
- fatty acid binding protein epidermal
- fatty acid-binding protein, heart
- fatty acid-binding protein, intestinal
- fkbp12-rapamycin complex-associated protein
- g protein-coupled receptor 119
- g protein-coupled receptor 34
- g protein-coupled receptor 44
- g-protein coupled receptor 105
- g-protein coupled receptor 14
- g-protein coupled receptor 159
- g-protein coupled receptor 16
- g-protein coupled receptor 24
- g-protein coupled receptor 30
- g-protein coupled receptor 38
- g-protein coupled receptor 39
- g-protein coupled receptor 40
- g-protein coupled receptor 41
- g-protein coupled receptor 43
- g-protein coupled receptor 44
- g-protein coupled receptor 54
- g-protein coupled receptor 65
- g-protein coupled receptor 66
- g-protein coupled receptor 68
- g-protein coupled receptor 73
- g-protein coupled receptor 74
- g-protein coupled receptor 94
- g-protein coupled receptor 97
- g-protein coupled receptor gpcr1
- g-protein coupled receptor gt01
- g-protein coupled receptor hlwar77
- g-protein coupled receptor hm74b
- g-protein coupled receptor rdc1
- g-protein subunit alpha-16
- gag-pol polyprotein (capsid protein)
- gamma carbonic anhydrase family protein
- gene-rich cluster protein c9
- glucose regulated protein 94kda (grp94)
- growth arrest-specific protein 6
- heat shock protein 90 (hsp90) ITC
- heat-shock protein 90 (hsp90)
- homeodomain-interacting protein kinase 1
- kinesin-5 motor protein (ksp)
- kinesin-like protein kif11 [d130v]
- liver regeneration-related protein lrrg199
- low molecular mass protein 2
- lpxtg-site transpeptidase family protein
- lymphocyte activation gene 1 protein
- lysosomal protective protein [29-480]
- lysyl oxidase-like protein 2
- mapk-activated protein kinase 1a
- metallo-beta-lactamase superfamily protein
- methyl-accepting chemotaxis protein (mcps)
- mitogen-activated protein kinase 10
- mitogen-activated protein kinase 2
- mitogen-activated protein kinase 3
- mitogen-activated protein kinase 4
- mitogen-activated protein kinase 6
- mitogen-activated protein kinase 8
- mitogen-activated protein kinase 9
- multidrug resistance-associated protein 2
- multidrug resistance-associated protein 3
- neuroendocrine-specific protein c homolog
- neuropeptide g-protein coupled receptor
- non-classical export protein 3
- non-specific protein-tyrosine kinase
- non-structural protein 5b (ns5b)
- osbp-related protein 4 (orp4s)
- otu domain-containing protein 3
- outer capsid protein sigma-1
- paired box protein pax-2
- pc4 and sfrs1-interacting protein
- pctaire-motif protein kinase 3
- pdh-containing protein june-1
- penicillin binding protein 3 (pbp3)
- phd finger protein 19 (phf19)
- potassium channel protein task-1
- programmed cell death protein 1
- prostate apoptosis response 4 protein
- protein arginine methyltransferase 1 (prmt1)
- protein arginine n-methyltransferase 10
- protein daf-12, isoform a
- protein kinase b (akt 1)
- protein kinase b (akt 2)
- protein kinase c alpha type
- protein kinase c beta type
- protein kinase c epsilon type
- protein mono-adp-ribosyltransferase parp12
- protein mono-adp-ribosyltransferase parp3
- protein-glutamine gamma-glutamyltransferase 6
- protein-glutamine gamma-glutamyltransferase e
- protein-glutamine gamma-glutamyltransferase k
- protein-tyrosine kinase erbb-1
- protein-tyrosine phosphatase 1b (ptp1b)
- protein-tyrosine phosphatase shp-1
- quorum-sensing regulator protein f
- ras guanyl releasing protein 1
- ras-related protein rab-29
- ras-related protein rab-2a
- ras-related protein rab-6a
- regulatory protein sir2 homolog 6
- regulatory-associated protein of mtor
- serine/threonine-protein kinase 13
- serine/threonine-protein kinase 22a
- serine/threonine-protein kinase akt
- serine/threonine-protein kinase als2cr7
- serine/threonine-protein kinase atr
- serine/threonine-protein kinase kkialre
- serine/threonine-protein kinase mst1
- serine/threonine-protein kinase nek2
- serine/threonine-protein kinase pim1 ITC
- serine/threonine-protein kinase rio2
- serine/threonine-protein kinase sik2
- serine/threonine-protein kinase sik3
- serine/threonine-protein kinase sstk
- serine/threonine-protein kinase tao1
- serine/threonine-protein kinase wnk2
- single stranded dna binding protein
- sodium-phosphate transport protein 2b
- stimulator of interferon genes protein
- tau protein kinase 1 (tpk1)
- thioredoxin domain-containing protein 5
- thioredoxin domain-containing protein 7
- tripartite motif-containing protein 58
- trk1-transforming tyrosine kinase protein
- tyrosine-protein kinase abl (t315i)
- tyrosine-protein kinase abl (y253h)
- tyrosine-protein kinase abl1 (e255k)
- tyrosine-protein kinase blk (blk)
- tyrosine-protein kinase btk (c481s)
- tyrosine-protein kinase jak1 (jak1)
- tyrosine-protein kinase jak2 [v617f]
- tyrosine-protein kinase met (cmet)
- tyrosine-protein kinase receptor [l1196m]
- tyrosine-protein kinase receptor etk1
- tyrosine-protein kinase receptor ros
- tyrosine-protein kinase receptor ufo
- tyrosine-protein kinase ret (ret)
- tyrosine-protein kinase src (e280v)
- tyrosine-protein kinase src (f278h)
- tyrosine-protein kinase src (src)
- tyrosine-protein kinase stk16 (stk16)
- valosin containing protein, p97 subunit
- vhl/tyrosine-protein kinase abl2
- wd repeat-containing protein 48
- wd repeat-containing protein 5
- wd repeat-containing protein 9
- wd repeat-containing protein 91
- x-box-binding protein 1
- Marković, V; Szczepańska, A; Berlicki, Ł Antiviral Protein-Protein Interaction Inhibitors. J Med Chem 67: 3205-3231 (2024)
- Patrone, JD; Kennedy, JP; Frank, AO; Feldkamp, MD; Vangamudi, B; Pelz, NF; Rossanese, OW; Waterson, AG; Chazin, WJ; Fesik, SW Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A. ACS Med Chem Lett 4: 601-605 (2013)
- Che, Y; Gilbert, AM; Shanmugasundaram, V; Noe, MC Inducing protein-protein interactions with molecular glues. Bioorg Med Chem Lett 28: 2585-2592 (2018)
- Barbay, JK; Chai, W; Hirst, GC; Kreutter, KD; Kummer, DA; McClure, KJ; Nishimura, RT; Shih, AY; Venable, JD; Venkatesan, H; Wei, J Inhibitors of KEAP1-Nrf2 protein-protein interaction US Patent US10947252 (2021)
- Wójcik, P; Berlicki, L Peptide-based inhibitors of protein-protein interactions. Bioorg Med Chem Lett 26: 707-13 (2016)
- Wang, S; Gegenfurtner, FA; Crevenna, AH; Ziegenhain, C; Kliesmete, Z; Enard, W; Müller, R; Vollmar, AM; Schneider, S; Zahler, S Chivosazole A Modulates Protein-Protein Interactions of Actin. J Nat Prod 82: 1961-1970 (2019)
- SHOJAEI, F; SEMPLE, JE; GILLINGS, M HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR US Patent US20230286948 (2023)
- Stevers, LM; Sijbesma, E; Botta, M; MacKintosh, C; Obsil, T; Landrieu, I; Cau, Y; Wilson, AJ; Karawajczyk, A; Eickhoff, J; Davis, J; Hann, M; O'Mahony, G; Doveston, RG; Brunsveld, L; Ottmann, C Modulators of 14-3-3 Protein-Protein Interactions. J Med Chem 61: 3755-3778 (2018)
- YOU, Q; GUO, X; SHOJAEI, F; CHEN, X; SEMPLE, JE; JIANG, Z; XU, X; GILLINGS, M PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR US Patent US20230286925 (2023)
- Massari, S; Goracci, L; Desantis, J; Tabarrini, O Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Protein-Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics. J Med Chem 59: 7699-718 (2016)
- Chrunyk, BA; Rosner, MH; Cong, Y; McColl, AS; Otterness, IG; Daumy, GO Inhibiting protein-protein interactions: a model for antagonist design Biochemistry 39: 7092-7099 (2000)
- Mou, Y; Wen, S; Li, YX; Gao, XX; Zhang, X; Jiang, ZY Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors. Eur J Med Chem 202: (2020)
- Watanabe, N; Osada, H Small molecules that target phosphorylation dependent protein-protein interaction. Bioorg Med Chem 24: 3246-54 (2016)
- Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Substituted carboxamides as inhibitors of WDR5 protein-protein binding US Patent US11174250 (2021)
- Laurent, A; Rose, Y Protein kinase inhibitors US Patent US9795608 (2017)
- Chua, PC; Haddach, M; Nagasawa, JY; Pierre, F; Whitten, JP Protein kinase modulators US Patent US8168651 (2012)
- TARGETED PROTEIN DEGRADATION
- Kassiou, M; James, ML; Luus, CA Translocator protein ligands US Patent US8492379 (2013)
- Moore, T; Lazzara, P; David, B; Richardson, B; Jain, AD 1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction US Patent US11396496 (2022)
- Bordas, V; Brocklehurst, C; Chene, P; Furet, P; Guagnano, V; Imbach-Weese, P; Kallen, J; Le Douget, M; Lorthiois, EL; McKenna, J; Salem, B; Schmelzle, T; Sellner, H; Soldermann, N; Voegtle, M; Wartmann, M Biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors US Patent US12083101 (2024)
- Valenti, D; Hristeva, S; Tzalis, D; Ottmann, C Clinical candidates modulating protein-protein interactions: The fragment-based experience. Eur J Med Chem 167: 76-95 (2019)
- Chan, AM; Goodis, CC; Pommier, EG; Fletcher, S Recent applications of covalent chemistries in protein-protein interaction inhibitors. RSC Med Chem 13: 921-928 (2022)
- Hu, L; Abed, DA Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction US Patent US12122742 (2024)
- Jacob, NT; Miranda, PO; Shirey, RJ; Gautam, R; Zhou, B; de Orbe Izquierdo, ME; Hixon, MS; Hart, JR; Ueno, L; Vogt, PK; Janda, KD Synthetic molecules for disruption of the MYC protein-protein interface. Bioorg Med Chem 26: 4234-4239 (2018)
- Scott, DE; Ehebauer, MT; Pukala, T; Marsh, M; Blundell, TL; Venkitaraman, AR; Abell, C; Hyvönen, M Using a fragment-based approach to target protein-protein interactions. Chembiochem 14: 332-42 (2013)
- Frank, AO; Feldkamp, MD; Kennedy, JP; Waterson, AG; Pelz, NF; Patrone, JD; Vangamudi, B; Camper, DV; Rossanese, OW; Chazin, WJ; Fesik, SW Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. J Med Chem 56: 9242-50 (2013)
- Shao, H; Li, X; Moses, MA; Gilbert, LA; Kalyanaraman, C; Young, ZT; Chernova, M; Journey, SN; Weissman, JS; Hann, B; Jacobson, MP; Neckers, L; Gestwicki, JE Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem 61: 6163-6177 (2018)
- Betzi, S; Restouin, A; Opi, S; Arold, ST; Parrot, I; Guerlesquin, F; Morelli, X; Collette, Y Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein. Proc Natl Acad Sci U S A 104: 19256-61 (2007)
- Qiu, Y; Li, X; He, X; Pu, J; Zhang, J; Lu, S Computational methods-guided design of modulators targeting protein-protein interactions (PPIs). Eur J Med Chem 207: (2020)
- Sanchez, TW; Debnath, B; Christ, F; Otake, H; Debyser, Z; Neamati, N Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions. Bioorg Med Chem 21: 957-63 (2013)
- Zhou, H; Zhou, W; Zhou, B; Liu, L; Chern, TR; Chinnaswamy, K; Lu, J; Bernard, D; Yang, CY; Li, S; Wang, M; Stuckey, J; Sun, Y; Wang, S High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein-Protein Interaction. J Med Chem 61: 1934-1950 (2018)
- LUKE, G; Babu, S INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) BINDING PROTEIN (CBP) US Patent US20240150347 (2024)
- Toogood, PL Inhibition of protein-protein association by small molecules: approaches and progress. J Med Chem 45: 1543-58 (2002)
- Li, K Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology. Bioorg Med Chem Lett 32: (2021)
- Lu, MC; Tan, SJ; Ji, JA; Chen, ZY; Yuan, ZW; You, QD; Jiang, ZY Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction Inhibitors. ACS Med Chem Lett 7: 835-40 (2016)
- Rational design of small-sized peptidomimetic inhibitors disrupting protein-protein interaction.
- Rechfeld, F; Gruber, P; Kirchmair, J; Boehler, M; Hauser, N; Hechenberger, G; Garczarczyk, D; Lapa, GB; Preobrazhenskaya, MN; Goekjian, P; Langer, T; Hofmann, J Thienoquinolines as novel disruptors of the PKCe/RACK2 protein-protein interaction. J Med Chem 57: 3235-46 (2014)
- HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS
- Zhang, D; Xie, G Indolinone protein kinase inhibitors US Patent US9163010 (2015)
- Zeitlmann, L; Niestroj, A; Heiser, U Inhibitors of protein kinases US Patent US9067888 (2015)
- Li, A; Li, S; Wang, P; Dang, C; Liu, D KRAS mutant protein inhibitors US Patent US12195473 (2025)
- Hanan, EJ; Liang, J; Wang, X; Blake, RA; Blaquiere, N; Staben, ST Monomeric Targeted Protein Degraders. J Med Chem 63: 11330-11361 (2020)
- Burns, CJ; Daigle, D; Chu, G; Hamrick, J; Boyd, SA; Zulli, AL; Mesaros, EF; Condon, SM; Trout, RE; Myers, CL; Xu, Z Penicillin-binding protein inhibitors US Patent US12173018 (2024)
- Johnson, PD; Leach, A; Luke, RW; Matusiak, ZS; Morris, JJ Protein kinase B inhibitors US Patent US9492453 (2016)
- Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions. Eur J Med Chem 205: (2020)
- Gambini, L; Baggio, C; Udompholkul, P; Jossart, J; Salem, AF; Perry, JJP; Pellecchia, M Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues. J Med Chem 62: 5616-5627 (2019)
- Tang, ML; Li, H; Ning, JF; Shen, X; Sun, X Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor J Med Chem 65: 6690-6709 (2022)
- Bedjeguelal, K; Bienaymé, H; Dumoulin, A; Poigny, S; Schmitt, P; Tam, E Discovery of protein-protein binding disruptors using multi-component condensations small molecules. Bioorg Med Chem Lett 16: 3998-4001 (2006)
- Sundberg, EJ; Urrutia, M; Braden, BC; Isern, J; Tsuchiya, D; Fields, BA; Malchiodi, EL; Tormo, J; Schwarz, FP; Mariuzza, RA Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface. Biochemistry 39: 15375-87 (2000)
- Guo, W; Wisniewski, JA; Ji, H Hot spot-based design of small-molecule inhibitors for protein-protein interactions. Bioorg Med Chem Lett 24: 2546-54 (2014)
- Carry, JC; Garcia-Echeverria, C Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic. Bioorg Med Chem Lett 23: 2480-5 (2013)
- Ferro, S; De Luca, L; Agharbaoui, FE; Christ, F; Debyser, Z; Gitto, R Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors. Bioorg Med Chem 23: 3208-14 (2015)
- Wells, JA; McClendon, CL Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450: 1001-1009 (2007)
- JI, H SMALL-MOLECULE INHIBITORS FOR BETA-CATENIN/BCELL LYMPHOMA 9 PROTEIN-PROTEIN INTERACTION US Patent US20240208940 (2024)
- Gonzalez, AZ; Eksterowicz, J; Bartberger, MD; Beck, HP; Canon, J; Chen, A; Chow, D; Duquette, J; Fox, BM; Fu, J; Huang, X; Houze, JB; Jin, L; Li, Y; Li, Z; Ling, Y; Lo, MC; Long, AM; McGee, LR; McIntosh, J; McMinn, DL; Oliner, JD; Osgood, T; Rew, Y; Saiki, AY; Shaffer, P; Wortman, S; Yakowec, P; Yan, X; Ye, Q; Yu, D; Zhao, X; Zhou, J; Olson, SH; Medina, JC; Sun, D Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem 57: 2472-88 (2014)
- Ozen, Z; Dash, RC; McCarthy, KR; Chow, SA; Rizzo, AA; Korzhnev, DM; Hadden, MK Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction. Bioorg Med Chem 26: 4301-4309 (2018)
- Al-awar, R; Isaac, M; Chau, AM; Mamai, A; Watson, I; Poda, G; Subramanian, P; Wilson, B; Uehling, D; Prakesch, M; Joseph, B; Morin, J Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction US Patent US11518764 (2022)
- Wang, ZH; Li, DD; Chen, WL; You, QD; Guo, XK Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy. Bioorg Med Chem 26: 356-365 (2018)
- He, Y; Selvaraju, S; Curtin, ML; Jakob, CG; Zhu, H; Comess, KM; Shaw, B; The, J; Lima-Fernandes, E; Szewczyk, MM; Cheng, D; Klinge, KL; Li, HQ; Pliushchev, M; Algire, MA; Maag, D; Guo, J; Dietrich, J; Panchal, SC; Petros, AM; Sweis, RF; Torrent, M; Bigelow, LJ; Senisterra, G; Li, F; Kennedy, S; Wu, Q; Osterling, DJ; Lindley, DJ; Gao, W; Galasinski, S; Barsyte-Lovejoy, D; Vedadi, M; Buchanan, FG; Arrowsmith, CH; Chiang, GG; Sun, C; Pappano, WN The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol 13: 389-395 (2017)
- Macdonald, JD; Chacón Simon, S; Han, C; Wang, F; Shaw, JG; Howes, JE; Sai, J; Yuh, JP; Camper, D; Alicie, BM; Alvarado, J; Nikhar, S; Payne, W; Aho, ER; Bauer, JA; Zhao, B; Phan, J; Thomas, LR; Rossanese, OW; Tansey, WP; Waterson, AG; Stauffer, SR; Fesik, SW Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J Med Chem 62: 11232-11259 (2019)
- Allen, JG; Bourbeau, MP; Wohlhieter, GE; Bartberger, MD; Michelsen, K; Hungate, R; Gadwood, RC; Gaston, RD; Evans, B; Mann, LW; Matison, ME; Schneider, S; Huang, X; Yu, D; Andrews, PS; Reichelt, A; Long, AM; Yakowec, P; Yang, EY; Lee, TA; Oliner, JD Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J Med Chem 52: 7044-53 (2009)
- Anderson, DR; Hegde, S; Reinhard, E; Gomez, L; Vernier, WF; Lee, L; Liu, S; Sambandam, A; Snider, PA; Masih, L Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett 15: 1587-90 (2005)
- Ji, H Inhibitors for the B-catenin/B-cell lymphoma 9 (BCL9) protein-protein interaction US Patent US11905273 (2024)
- Dias, DM; Van Molle, I; Baud, MG; Galdeano, C; Geraldes, CF; Ciulli, A Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions? ACS Med Chem Lett 5: 23-28 (2014)
- Sperl, B; Seifert, MH; Berg, T Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains. Bioorg Med Chem Lett 19: 3305-9 (2009)
- Colarusso, S; De Simone, D; Frattarelli, T; Andreini, M; Cerretani, M; Missineo, A; Moretti, D; Tambone, S; Kempf, G; Augustin, M; Steinbacher, S; Munoz-Sanjuan, I; Park, L; Summa, V; Tomei, L; Bresciani, A; Dominguez, C; Toledo-Sherman, L; Bianchi, E Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction. Bioorg Med Chem 28: (2020)
- Anderson, DR; Meyers, MJ; Vernier, WF; Mahoney, MW; Kurumbail, RG; Caspers, N; Poda, GI; Schindler, JF; Reitz, DB; Mourey, RJ Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem 50: 2647-54 (2007)
- Shi, Y; Sang, P; Lu, J; Higbee, P; Chen, L; Yang, L; Odom, T; Daughdrill, G; Chen, J; Cai, J Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein-Protein Interactions. J Med Chem 63: 13187-13196 (2020)
- Blevitt, JM; Hack, MD; Herman, KL; Jackson, PF; Krawczuk, PJ; Lebsack, AD; Liu, AX; Mirzadegan, T; Nelen, MI; Patrick, AN; Steinbacher, S; Milla, ME; Lumb, KJ Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. J Med Chem 60: 3511-3517 (2017)
- Krüger, DM; Glas, A; Bier, D; Pospiech, N; Wallraven, K; Dietrich, L; Ottmann, C; Koch, O; Hennig, S; Grossmann, TN Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions. J Med Chem 60: 8982-8988 (2017)
- Structure-based discovery of small molecule inhibitors of FKBP51-Hsp90 protein-protein interaction.
- Al-awar, R; Isaac, M; Chau, AM; Mamai, A; Watson, I; Poda, G; Subramanian, P; Wilson, B; Uehling, D Tricyclic inhibitors of the BCL6 BTB domain protein-protein interaction and uses thereof US Patent US11242351 (2022)
- ChEMBL_2270595 Inhibition of human Keap1-Nrf2 protein-protein interaction
- ChEMBL_2265318 Inhibition of human PD-1/PDL1 protein-protein interaction
- ChEMBL_2274176 Inhibition of KEAP1/Nrf2 (unknown origin) protein-protein interaction
- ChEMBL_2372439 Inhibition of SOS1/KRAS (unknown origin) protein-protein interaction
- ChEMBL_161742 (CHEMBL769032) Inhibition of cAMP-dependent protein kinase (Protein kinase A)
- ChEMBL_1882721 (CHEMBL4384220) Inhibition of PAC3 homodimer (unknown origin) protein-protein interaction
- ChEMBL_2054557 (CHEMBL4709558) Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction
- ChEMBL_2227786 (CHEMBL5141299) Inhibition of human CDK16/cyclin-Y protein-protein complex
- ChEMBL_2302073 Inhibition of beta catenin/Tcf4 (unknown origin) protein protein interaction
- ChEMBL_2322124 Inhibition of beta-Catenin/TCF4 (unknown origin) protein-protein interaction
- Inhibition Assay Inhibition of a protein-protein activity by EMSA assay.
- ChEBML_50454 Inhibition of DNA dependent protein kinase activity without hsp90 alpha protein
- ChEMBL_1882722 (CHEMBL4384221) Inhibition of PAC1/PAC2 heterodimer (unknown origin) protein-protein interaction
- ChEMBL_2169505 (CHEMBL5054564) Inhibition of PD-1/PDL1 protein-protein interaction (unknown origin)
- ChEMBL_2270585 Inhibition of human Keap1-Nrf2 protein-protein interaction by ELISA method
- ChEMBL_2378276 Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction
- ChEMBL_2378400 Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction
- ChEMBL_2454243 Inhibition of PD-1/PD-L1 (unknown origin) protein protein interaction
- ChEMBL_2455117 Inhibition of SOS1/KRAS G12D mutant (unknown origin) protein-protein interaction
- ChEMBL_2477236 Inhibition of PD-1/PD-L1 (unknown origin) protein-protein interaction
- ChEMBL_2500660 Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction
- ChEMBL_50455 (CHEMBL657325) Inhibition of DNA dependent protein kinase with hsp90 alpha protein
- ChEMBL_96757 (CHEMBL705380) Inhibitory activity against Serine/Threonine Protein Phosphatase (Lambda protein phosphatase)
- ChEBML_66420 Binding affinity towards immunophilin cytosolic protein FK506 binding protein 12 was determined
- ChEMBL_1980087 (CHEMBL4613349) Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assay
- ChEMBL_1988149 (CHEMBL4621696) Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assay
- ChEMBL_221025 (CHEMBL822642) Inhibition of protein kinase C (PKC) using histone III S protein
- ChEMBL_2265317 Inhibition of human PD-1/PDL1 protein-protein interaction by HTRF assay
- ChEMBL_2270592 Inhibition of human Keap1-Nrf2 protein-protein interaction by fluorescence polarization assay
- ChEMBL_2322125 Inhibition of beta-Catenin/TCF4 protein-protein interaction in human Hep3B cells
- ChEMBL_2322159 Inhibition of beta-Catenin/TCF4 protein-protein interaction in human HepG2 cells
- ChEMBL_2469990 Inhibition of beta-catenin (unknown origin)/BCL9 (unknown origin) protein-protein interaction
- ChEMBL_50454 (CHEMBL662174) Inhibition of DNA dependent protein kinase activity without hsp90 alpha protein