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Query String: cabozantinib

CABOZANTINIB US12304898, Example Cabozantinib Cometriq US10227329, Compound Cabozantinib US20240174674, Compound Cabozantinib Cabometyx US10202365, Compound Cabozantinib CHEBI:72317 US12338253, Compound Cabozantinib US10464902, Cabozantinib BDBM50021574 BMS-907351 US11279688, Compound Cabozantinib cabozantinib s-malate US10183928, Cabozantinib XL-184 US10273211, Compound Cabozantinib US10774070, Compound Cabozantinib

In-Vitro Kinase Inhibition Assay Compounds 2-4 and cabozantinib were each tested for binding of c-Met, VEGFR2, TIE2 and the control compound, staurosporine. Specifically, each compound was tested at a 3-fold serial dilution starting at 10 microMolar ( μM ) in a 10-dose IC50 mode into an enzyme/substrate mixture using acoustic technology, and pre-incubated for 20 minutes to ensure compounds were equilibrated and bound to the enzyme. Staurosporine was used as a control and was tested at a 4-fold serial dilution starting at 20 μM. Next, 5 concentrations of ATP were added to initiate the reaction. The activity was monitored every 5-15 min for a time course study.