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Query String: genetic inhibition

ANSARI, A; JEFFRIES, SJ; SHAH, P; ZHANG, C METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE US Patent US20240050576 (2024)
Nagashima, K; Shumway, SD; Sathyanarayanan, S; Chen, AH; Dolinski, B; Xu, Y; Keilhack, H; Nguyen, T; Wiznerowicz, M; Li, L; Lutterbach, BA; Chi, A; Paweletz, C; Allison, T; Yan, Y; Munshi, SK; Klippel, A; Kraus, M; Bobkova, EV; Deshmukh, S; Xu, Z; Mueller, U; Szewczak, AA; Pan, BS; Richon, V; Pollock, R; Blume-Jensen, P; Northrup, A; Andersen, JN Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor. J Biol Chem 286: 6433-48 (2011)
Beceiro, A; Pérez, A; Fernández-Cuenca, F; Martínez-Martínez, L; Pascual, A; Vila, J; Rodríguez-Baño, J; Cisneros, JM; Pachón, J; Bou, G Genetic variability among ampC genes from acinetobacter genomic species 3. Antimicrob Agents Chemother 53: 1177-84 (2009)
Power, P; Di Conza, J; Rodríguez, MM; Ghiglione, B; Ayala, JA; Casellas, JM; Radice, M; Gutkind, G Biochemical characterization of PER-2 and genetic environment of blaPER-2. Antimicrob Agents Chemother 51: 2359-65 (2007)
Min, J; Kyung Kim, Y; Cipriani, PG; Kang, M; Khersonsky, SM; Walsh, DP; Lee, JY; Niessen, S; Yates, JR; Gunsalus, K; Piano, F; Chang, YT Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. Nat Chem Biol 3: 55-9 (2007)
Ford, DJ; Duggan, NM; Fry, SE; Ripoll-Rozada, J; Agten, SM; Liu, W; Corcilius, L; Hackeng, TM; van Oerle, R; Spronk, HMH; Ashhurst, AS; Mini Sasi, V; Kaczmarski, JA; Jackson, CJ; Pereira, PJB; Passioura, T; Suga, H; Payne, RJ Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming. J Med Chem 64: 7853-7876 (2021)
Datta, S; Bucks, ME; Koley, D; Lim, PX; Savinov, SN Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system. Bioorg Med Chem 18: 6099-108 (2010)
Menzella, HG; Tran, TT; Carney, JR; Lau-Wee, J; Galazzo, J; Reeves, CD; Carreras, C; Mukadam, S; Eng, S; Zhong, Z; Timmermans, PB; Murli, S; Ashley, GW Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus. J Med Chem 52: 1518-21 (2009)
So, SS; Karplus, M Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications. J Med Chem 40: 4360-71 (1998)
Lai, W; Huang, L; Ho, P; Li, Z; Montefiori, D; Chen, CH Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1. Antimicrob Agents Chemother 52: 128-36 (2008)
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Meziane-Cherif, D; Lambert, T; Dupêchez, M; Courvalin, P; Galimand, M Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. Antimicrob Agents Chemother 52: 1264-8 (2008)
Miller, M; Pal, A; Albusairi, W; Joo, H; Pappas, B; Haque Tuhin, MT; Liang, D; Jampala, R; Liu, F; Khan, J; Faaij, M; Park, M; Chan, W; Graef, I; Zamboni, R; Kumar, N; Fox, J; Sinha, U; Alhamadsheh, M Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. J Med Chem 61: 7862-7876 (2018)
So, SS; Karplus, M Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors. J Med Chem 39: 5246-56 (1997)
Fang, G; Xue, M; Su, M; Hu, D; Li, Y; Xiong, B; Ma, L; Meng, T; Chen, Y; Li, J; Li, J; Shen, J CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design. Bioorg Med Chem Lett 22: 4540-5 (2012)
Hoffman, BT; Kopajtic, T; Katz, JL; Newman, AH 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. J Med Chem 43: 4151-9 (2000)
Koval, VS; Arutyunyan, AF; Salyanov, VI; Kostyukov, AA; Melkina, OE; Zavilgelsky, GB; Klimova, RR; Kushch, AA; Korolev, SP; Agapkina, YY; Gottikh, MB; Vaiman, AV; Rybalkina, EY; Susova, OY; Zhuze, AL DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n). Bioorg Med Chem 28: (2020)
Borowski, T; Król, M; Broclawik, E; Baranowski, TC; Strekowski, L; Mokrosz, MJ Application of similarity matrices and genetic neural networks in quantitative structure-activity relationships of 2- or 4-(4-Methylpiperazino)pyrimidines: 5-HT(2A) receptor antagonists. J Med Chem 43: 1901-9 (2000)
Li, Q; Ma, L; Innis, RB; Seneca, N; Ichise, M; Huang, H; Laruelle, M; Murphy, DL Pharmacological and genetic characterization of two selective serotonin transporter ligands: 2-[2-(dimethylaminomethylphenylthio)]-5-fluoromethylphenylamine (AFM) and 3-amino-4-[2-(dimethylaminomethyl-phenylthio)]benzonitrile (DASB). J Pharmacol Exp Ther 308: 481-6 (2004)
Bi, Y; Might, M; Vankayalapati, H; Kuberan, B Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease. Bioorg Med Chem Lett 27: 2962-2966 (2017)
Nandakumar, M; Ollodart, A; Fleck, N; Kapadia, NR; Frando, A; Boradia, V; Smith, JL; Chen, J; Zuercher, WJ; Willson, TM; Grundner, C Dual Inhibition of J Med Chem 66: 14724-14734 (2023)
Kitano, Y; Shinozuka, T Inhibition of Na RSC Med Chem 13: 895-920 (2022)
Gao, Y; van Haren, MJ; Buijs, N; Innocenti, P; Zhang, Y; Sartini, D; Campagna, R; Emanuelli, M; Parsons, RB; Jespers, W; Gutiérrez-de-Terán, H; van Westen, GJP; Martin, NI Potent Inhibition of Nicotinamide J Med Chem 64: 12938-12963 (2021)
Atack, TC; Raymond, DD; Blomquist, CA; Pasaje, CF; McCarren, PR; Moroco, J; Befekadu, HB; Robinson, FP; Pal, D; Esherick, LY; Ianari, A; Niles, JC; Sellers, WR Targeted Covalent Inhibition of ACS Med Chem Lett 11: 2131-2138 (2020)
PubChem, PC mTOR Inhibition with eCF309 PubChem Bioassay (2016)
Thompson, KR; Finke, PE; Shah, SK; Ashe, BM; Dahlgren, ME; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 6. Inhibition by 6-substituted penicillin esters. Bioorg Med Chem Lett 3: 2283-2288 (1993)
Thompson, KR; Finke, PE; Shah, SK; Ashe, BM; Dahlgren, ME; Dellea, PS; Fletcher, DS; Hand, KM; Maycock, AL; Doherty, JB Inhibition of human leukocyte elastase. 7. Inhibition by 6-substituted penicillin amides. Bioorg Med Chem Lett 3: 2289-2294 (1993)
Finke, PE; Ashe, BM; Knight, WB; Maycock, AL; Navia, MA; Shah, SK; Thompson, KR; Underwood, DJ; Weston, H; Zimmerman, M Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides. J Med Chem 33: 2522-8 (1990)
Valenti, P; Rampa, A; Bisi, A; Andrisano, V; Cavrini, V; Fin, L; Buriani, A; Giusti, P Acetylcholinesterase inhibition by tacrine analogues Bioorg Med Chem Lett 7: 2599-2602 (1997)
SALPETER, SJ; NAIM, M; GRANOT, Z; FRIDLENDER, ZG COMPOUNDS FOR NEUTROPHIL ROS INHIBITION US Patent US20240358711 (2024)
Ricardo, A; Tucker, TJ; Boyer, NC; Stringer, JR; LaPlaca, DM; Kerekes, AD; Wu, C; Ha, SN; Youm, H; Embrey, MW; Bianchi, E; Branca, D; Ingenito, R; Costantini, W; Santoprete, A; Costante, R; Conte, I; Colarusso, S; Gilbert, EJ; Shahripour, A; Xiong, Y Cyclic polypeptides for PCSK9 inhibition US Patent US11530244 (2022)
Yang, J; Cen, JJ; Fan, XM Epoxyketone compounds for enzyme inhibition US Patent US10640533 (2020)
Huang, W; Gong, Y; Li, F; Bencivenga, NE; Dalgarno, DC; Kohlmann, A; Shakespeare, WC; Thomas, RM; Zhu, X; West, A; Youngsaye, W; Zhang, Y; Zhou, T Heteroaryl compounds for kinase inhibition US Patent US10227342 (2019)
Daum, S; Schumann, M; Mathea, S; Aumüller, T; Balsley, MA; Constant, SL; de Lacroix, BF; Kruska, F; Braun, M; Schiene-Fischer, C Isoform-specific inhibition of cyclophilins. Biochemistry 48: 6268-77 (2009)
Wang, J; Radomski, MW; Medina, C; Gilmer, JF MMP inhibition by barbiturate homodimers. Bioorg Med Chem Lett 23: 444-7 (2012)
Kim, EJ; Love, DC; Darout, E; Abdo, M; Rempel, B; Withers, SG; Rablen, PR; Hanover, JA; Knapp, S OGA inhibition by GlcNAc-selenazoline. Bioorg Med Chem 18: 7058-64 (2010)
Liu, X; Ding, CZ; Chen, S; Wu, L; Hu, L; Wan, H Quinazoline compound for EGFR inhibition US Patent US11040984 (2021)
Filippakopoulos, P; Qi, J; Picaud, S; Shen, Y; Smith, WB; Fedorov, O; Morse, EM; Keates, T; Hickman, TT; Felletar, I; Philpott, M; Munro, S; McKeown, MR; Wang, Y; Christie, AL; West, N; Cameron, MJ; Schwartz, B; Heightman, TD; La Thangue, N; French, CA; Wiest, O; Kung, AL; Knapp, S; Bradner, JE Selective inhibition of BET bromodomains. Nature 468: 1067-73 (2010)
Li, JJ; Shanmugasundaram, V; Reddy, S; Fleischer, LL; Wang, Z; Smith, Y; Harter, WG; Yue, WS; Swaroop, M; Li, L; Ji, CX; Dettling, D; Osak, B; Fitzgerald, LR; Conradi, R Smoothened antagonists for hair inhibition. Bioorg Med Chem Lett 20: 4932-5 (2010)
Muller, GW; Shire, MG; Wong, LM; Corral, LG; Patterson, RT; Chen, Y; Stirling, DI Thalidomide analogs and PDE4 inhibition. Bioorg Med Chem Lett 8: 2669-74 (1998)