BDBM82509 melatonin, 6-Hydroxy Melatonin,6-Hydroxy
BDBM85063 Melatonin,6-Cl
Melatonin,2-Chloro BDBM85236
melatonin, 6-Methoxy BDBM82556
BDBM29611 CHEMBL289233 2-Iodomelatonin Melatonin,2-Iodo
CHEMBL498494 BDBM50272623 (+/-)-2-(2-Hydroxymethylindolin-1-ylmethyl)-melatonin
BDBM85061 CAS_73-31-4 Melatonin,6-Cl-2-Me
CHEMBL498493 2-((S)-2-Hydroxymethylindolin-1-ylmethyl)-melatonin BDBM50272622
BDBM50272621 CHEMBL525374 (+/-)-2-(2-Hydroxymethyl-5-methoxyindolin-1-ylmethyl)-melatonin
BDBM85055 Melatonin,6,7 di-cl-2-Me CAS_73-31-4
BDBM9019 CHEMBL45 Melatonin N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
BDBM50066958 N-[2-(6-Methoxy-1H-indol-3-yl)-ethyl]-acetamide CHEMBL33099 Melatonin,6-Methoxy
Melatonin,2-Phenyl N-[2-(5-Methoxy-2-phenyl-1H-indol-3-yl)-ethyl]-acetamide CHEMBL15060 BDBM50034110
CHEMBL33415 Melatonin,2-Bromo N-[2-(2-Bromo-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide BDBM50043287 N-[2-(2-Bromo-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide(2-Bromomelatonin)
N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide(6-Chloromelatonin) melatonin, 6-Chloro N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide BDBM50043289 CHEMBL34730
6-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(1H-indol-3-yl)-ethyl]-amide BDBM9006 N-[2-(1H-indol-3-yl)ethyl]-6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexanamide Tacrine-Melatonin Hybrid 3a
BDBM9007 7-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-heptanoic acid [2-(1H-indol-3-yl)-ethyl]-amide Tacrine-Melatonin Hybrid 3b N-[2-(1H-indol-3-yl)ethyl]-7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptanamide
6-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(5-hydroxy-1H-indol-3-yl)-ethyl]-amide Tacrine-Melatonin Hybrid 11a BDBM9018 N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexanamide
N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptanamide 7-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-heptanoic acid [2-(1H-indol-5-metoxy-3-yl)-ethyl]-amide Tacrine-Melatonin Hybrid 7b BDBM9014
Tacrine-Melatonin Hybrid 7a BDBM9013 N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexanamide 6-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide
6-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]hexanamide BDBM9011 6-(6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(1H-indol-3-yl)-ethyl]-amide Tacrine-Melatonin Hybrid 6a
BDBM9008 6-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(1H-indol-3-yl)-ethyl]-amide 6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]hexanamide Tacrine-Melatonin Hybrid 4a
BDBM9009 7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanamide Tacrine-Melatonin Hybrid 4b 7-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-heptanoic acid [2-(1H-indol-3-yl)-ethyl]-amide
Tacrine-Melatonin Hybrid 5a 6-(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(1H-indol-3-yl)-ethyl]-amide 6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]hexanamide BDBM9010
7-(6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-heptanoic acid [2-(1H-indol-3-yl)-ethyl]-amide BDBM9012 Tacrine-Melatonin Hybrid 6b CHEMBL199585 7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanamide
BDBM9017 Tacrine-Melatonin Hybrid 10b 7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]heptanamide 7-(6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-heptanoic acid [2-(5-methoxy-1Hindol-3-yl)-ethyl]-amide
6-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide BDBM9015 6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]hexanamide Tacrine-Melatonin Hybrid 8a
BDBM9016 Tacrine-Melatonin Hybrid 9a 6-(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide 6-[(8-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]hexanamide
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- Spadoni, G; Bedini, A; Furiassi, L; Mari, M; Mor, M; Scalvini, L; Lodola, A; Ghidini, A; Lucini, V; Dugnani, S; Scaglione, F; Piomelli, D; Jung, KM; Supuran, CT; Lucarini, L; Durante, M; Sgambellone, S; Masini, E; Rivara, S Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit. J Med Chem 61: 7902-7916 (2018)
- López-Iglesias, B; Pérez, C; Morales-García, JA; Alonso-Gil, S; Pérez-Castillo, A; Romero, A; López, MG; Villarroya, M; Conde, S; Rodríguez-Franco, MI New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. J Med Chem 57: 3773-85 (2014)
- Spadoni, G; Bedini, A; Orlando, P; Lucarini, S; Tarzia, G; Mor, M; Rivara, S; Lucini, V; Pannacci, M; Scaglione, F Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors. Bioorg Med Chem 19: 4910-6 (2011)
- Tsotinis, A; Vlachou, M; Papahatjis, DP; Calogeropoulou, T; Nikas, SP; Garratt, PJ; Piccio, V; Vonhoff, S; Davidson, K; Teh, MT; Sugden, D Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines. J Med Chem 49: 3509-19 (2006)
- Koike, T; Takai, T; Hoashi, Y; Nakayama, M; Kosugi, Y; Nakashima, M; Yoshikubo, S; Hirai, K; Uchikawa, O Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands. J Med Chem 54: 4207-18 (2011)
- Millan, MJ; Gobert, A; Lejeune, F; Dekeyne, A; Newman-Tancredi, A; Pasteau, V; Rivet, JM; Cussac, D The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306: 954-64 (2003)
- Teh, MT; Sugden, D Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol 358: 522-8 (1998)
- Dubocovich, ML; Masana, MI; Iacob, S; Sauri, DM Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997)
- Benchekroun, M; Romero, A; Egea, J; León, R; Michalska, P; Buendía, I; Jimeno, ML; Jun, D; Janockova, J; Sepsova, V; Soukup, O; Bautista-Aguilera, OM; Refouvelet, B; Ouari, O; Marco-Contelles, J; Ismaili, L The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators. J Med Chem 59: 9967-9973 (2016)
- ChEMBL_104616 (CHEMBL715564) Binding affinity towards melatonin receptor, determined in chicken brain membranes using [2-125I]melatonin
- ChEMBL_104930 (CHEMBL714710) Binding affinity against ovine pars tuberalis melatonin receptor using 2-[125I]- melatonin radioligand binding assay
- ChEMBL_104755 (CHEMBL712438) Binding affinity towards melatonin receptor
- ChEMBL_104780 (CHEMBL874168) inhibitory concentration against Melatonin receptor
- ChEMBL_624959 (CHEMBL1107082) Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting
- ChEMBL_624960 (CHEMBL1107083) Displacement of [3H]melatonin from human melatonin MT2 receptor expressed in CHO cells after 60 mins by scintillation counting
- ChEBML_104949 Binding affinity towards human melatonin receptor type 1A
- ChEBML_105091 In vitro receptor binding at MT1 (Melatonin) receptor.
- ChEBML_105255 In vitro receptor binding at MT2 (Melatonin) receptor.
- ChEBML_105277 Binding affinity towards human melatonin receptor type 1B
- ChEMBL_105242 (CHEMBL712572) Binding affinity against melatonin receptor type 1A
- ChEMBL_305096 (CHEMBL832400) Inhibitory concentration against Melatonin receptor type 1A
- ChEMBL_305097 (CHEMBL832401) Inhibitory concentration against Melatonin receptor type 1B
- ChEMBL_644101 (CHEMBL1212000) Inhibition of human melatonin receptor type 1B
- Binding Assay Binding assay using melatonin receptors 1 or 2.
- ChEMBL_104619 (CHEMBL715567) Binding affinity towards melatonin receptor in chicken brain.
- ChEMBL_105110 (CHEMBL715953) Binding Affinity (pKi) towards Melatonin receptor type 1A
- ChEMBL_105255 (CHEMBL710591) In vitro receptor binding at MT2 (Melatonin) receptor.
- ChEMBL_104752 (CHEMBL712435) Binding affinity towards melatonin receptor in Chicken retinal membranes
- ChEMBL_104939 (CHEMBL714718) Inhibitory concentration against melatonin receptor by nonlinear fiting strategies
- ChEMBL_105111 (CHEMBL715954) Binding Affinity (pKi) towards human Melatonin receptor type 1A
- ChEMBL_105243 (CHEMBL712573) Binding affinity against human Melatonin receptor type 1A (MT1)
- ChEMBL_105272 (CHEMBL858415) Binding Affinity (pKi) towards human Melatonin receptor type 1B
- ChEMBL_105275 (CHEMBL718943) Binding affinity against human Melatonin receptor type 1B (MT2)
- ChEBML_105102 Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.
- ChEBML_105266 Binding affinity against human MT2 melatonin receptor expressed in NIH3T3 cells
- ChEMBL_104615 (CHEMBL715563) Inhibition of 2-[125I]- iodomelatonin from chicken brain melatonin receptors
- ChEMBL_104620 (CHEMBL715568) Binding affinity towards melatonin receptor in Chicken brain Experiment 1
- ChEMBL_104751 (CHEMBL715876) Binding affinity towards melatonin receptor in Chicken brain Experiment 2
- ChEMBL_104774 (CHEMBL714919) Agonist activity against melatonin receptor in the presence of iodomelatonin
- ChEMBL_104775 (CHEMBL714920) Agonist activity against melatonin receptor in the presence of iodomelatonin
- ChEMBL_1824682 (CHEMBL4324446) Displacement of 2-[125I]iodomelatonin from melatonin receptor (unknown origin)
- ChEMBL_1824703 (CHEMBL4324467) Displacement of 2-[125I]iodomelatonin from chick brain melatonin receptor
- ChEMBL_2238442 (CHEMBL5152338) Binding affinity to human melatonin MT1 assessed as inhibition constant
- ChEMBL_104614 (CHEMBL713592) Functional activity against melatonin receptor in lightening Xenopus laevis tadpole skin
- ChEMBL_104784 (CHEMBL714927) Binding affinity for Melatonin receptor using 2-[125I]iodomelatonin as radioligand
- ChEMBL_104925 (CHEMBL714705) Binding affinity to melatonin receptor measured on ovine pars tuberalis membrane
- ChEMBL_104772 (CHEMBL714917) Agonist activity against melatonin receptor was tested in the absence of iodomelatonin
- ChEMBL_104773 (CHEMBL714918) Agonist activity against melatonin receptor was tested in the absence of iodomelatonin
- ChEMBL_2272288 Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells
- ChEMBL_2272289 Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells
- ChEMBL_744413 (CHEMBL1772367) Binding affinity to low affinity melatonin (MT3) site of quinone reductase 2
- ChEMBL_104764 (CHEMBL714909) Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand
- ChEMBL_104924 (CHEMBL714704) Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.
- ChEMBL_304028 (CHEMBL840206) Binding affinity for human recombinant Melatonin receptor type 2 expressed in NIH3T3 cells
- ChEMBL_304031 (CHEMBL840209) Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells
- ChEMBL_744409 (CHEMBL1772363) Binding affinity to human low affinity melatonin (MT3) site of quinone reductase 2
- ChEBML_104948 Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand
- ChEBML_105103 Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells
- ChEBML_105267 Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells
- ChEBML_105276 Binding affinity against human Melatonin receptor type 1B by using 2-[125I]iodomelatonin as radioligand
- ChEBML_219514 Binding affinity measured against Chicken brain melatonin receptor by using 2-[125I]iodomelatonin as radioligand
- ChEMBL_104759 (CHEMBL710991) Effect of compound on Melatonin receptor in chicken brain in the presence of MnCl2
- ChEMBL_514503 (CHEMBL973545) Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells
- ChEMBL_514504 (CHEMBL973546) Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells
- ChEMBL_544427 (CHEMBL1016924) Displacement of [125I]iodomelatonin from MT3/QR2 melatonin binding site expressed in CHO cells
- ChEMBL_104753 (CHEMBL712436) Binding affinity towards melatonin receptor using 2-[125I]iodomelatonin as radioligand in chick brain membranes
- ChEMBL_104779 (CHEMBL714924) Inhibitory activity against melatonin receptor of quail optica tecta with 200 pM 2-[125] iodomelatonin
- ChEMBL_104785 (CHEMBL714928) Inhibition of 2-[125I]iodomelatonin binding to melatonin receptor in quail brain as 1/Ka
- ChEMBL_105267 (CHEMBL713139) Compound was tested for binding affinity against human Melatonin receptor type 1B in CHO cells
- ChEMBL_219514 (CHEMBL824491) Binding affinity measured against Chicken brain melatonin receptor by using 2-[125I]iodomelatonin as radioligand
- ChEMBL_104609 (CHEMBL712996) Effective concentration against human MT2 (Melatonin) receptor stably expressed in NIH3T3 cells in adenylyl cyclase assay
- ChEMBL_104758 (CHEMBL710990) Effect of compound on Melatonin receptor in chicken brain in the presence of GTP-gamma-S
- ChEMBL_104942 (CHEMBL713109) Inhibition of 2-[125I]iodomelatonin binding to Melatonin receptor 3 (MT3) of Syrian hamster brain membrane
- ChEMBL_104950 (CHEMBL713259) Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells
- ChEMBL_105104 (CHEMBL715948) Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells
- ChEMBL_105269 (CHEMBL713141) Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1B expressed in CHO cells
- ChEMBL_105404 (CHEMBL710823) Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in HEK293 cells
- ChEMBL_303517 (CHEMBL839631) Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
- ChEMBL_303518 (CHEMBL839632) Binding affinity against Melatonin receptor type 1B stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin
- ChEMBL_512176 (CHEMBL968035) Agonist activity at CPR119 transfected in Xenopus dermal melanophore assessed as dispersion of melatonin-induced pigmentation
- ChEBML_105098 Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells
- ChEBML_105100 Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A
- ChEBML_105262 Binding affinity against human Melatonin receptor type 1B by displacement of [125I]iodomelatonin stably expressed in CHO cells
- ChEBML_105264 Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
- ChEMBL_104611 (CHEMBL713590) Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay.
- ChEMBL_104754 (CHEMBL712437) Binding affinity in chicken brain membranes by using [2-125I]melatonin in a competition radioligand binding assay
- ChEMBL_104756 (CHEMBL712439) Binding affinity towards melatonin receptor was determined using 2-[125I]iodomelatonin as radioligand in chick brain membranes
- ChEMBL_104757 (CHEMBL712440) Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes
- ChEMBL_104760 (CHEMBL710992) In vitro binding affinity against melatonin receptor using 2-[125I]iodomelatonin (0.05 nM) and chicken brain membranes
- ChEMBL_104776 (CHEMBL714921) Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand
- ChEMBL_104777 (CHEMBL714922) Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligand
- ChEMBL_104783 (CHEMBL714926) Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligand
- ChEMBL_104940 (CHEMBL714719) Ability to inhibit 2-[125I]iodomelatonin specific binding to melatonin receptor 3 (MT3) of Syrian hamster brain.
- ChEMBL_105108 (CHEMBL856174) Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.
- ChEMBL_1286910 (CHEMBL3110824) Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor expressed in CHO cells after 120 mins
- ChEMBL_1286911 (CHEMBL3110825) Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins
- ChEMBL_1560583 (CHEMBL3777315) Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins
- ChEMBL_1560584 (CHEMBL3777316) Displacement of 2-[125I]Iodomelatonin from human MT2 melatonin receptor expressed in HEK cells after 120 mins
- ChEMBL_304060 (CHEMBL839735) Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor MT2 expressed in NIH3T3 rat fibroblast cells
- ChEMBL_105109 (CHEMBL715952) Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.
- ChEMBL_105244 (CHEMBL712574) Binding affinity for melatonin receptor type 1B, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
- ChEMBL_105273 (CHEMBL713144) Binding affinity towards melatonin receptor type 1B stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin
- ChEMBL_1499384 (CHEMBL3583713) Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins
- ChEMBL_1499385 (CHEMBL3583714) Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-2 transfected in CHO cell membranes after 120 mins
- ChEMBL_104613 (CHEMBL884504) The functional activity on melatonin receptor was evaluated by its potency to lighten the skin of Xenopus laevis tadpoles
- ChEMBL_104782 (CHEMBL714925) Binding affinity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin (100 pM) as labelled ligand
- ChEMBL_104944 (CHEMBL713111) Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)
- ChEMBL_104946 (CHEMBL713113) Ability to inhibit 2-[125I]iodomelatonin specific binding to human melatonin receptor type 1A (MT1) expressed in CHO cells.
- ChEMBL_105080 (CHEMBL711325) Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A
- ChEMBL_105248 (CHEMBL709923) Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B
- ChEMBL_1499387 (CHEMBL3583716) Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
- ChEMBL_1499389 (CHEMBL3583718) Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay
- ChEMBL_303582 (CHEMBL828981) Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A
- ChEMBL_303583 (CHEMBL828124) Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1B
- ChEMBL_304083 (CHEMBL838521) Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells
- ChEMBL_304084 (CHEMBL838522) Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1B (MT2) expressed in NIH3T3 rat fibroblast cells
- ChEMBL_310710 (CHEMBL838055) Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation
- ChEMBL_310711 (CHEMBL838056) Agonist activity towards human Melatonin receptor type 1B was determined by its ability to inhibit forskolin stimulated cAMP accumulation
- ChEMBL_939502 (CHEMBL2328137) Displacement of [3H]melatonin from human MT2 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
- ChEMBL_939503 (CHEMBL2328138) Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method
- ChEMBL_105083 (CHEMBL710854) Intrinsic activity of Melatonin receptor type 1A evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
- ChEMBL_104778 (CHEMBL714923) Inhibitory activity against melatonin receptor of quail optica tecta with 200 pM 2-[125] iodomelatonin as gamma-S (10e-4 M)
- ChEMBL_105082 (CHEMBL710853) Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A
- ChEMBL_105101 (CHEMBL715945) Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
- ChEMBL_105249 (CHEMBL709924) Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
- ChEMBL_105250 (CHEMBL710586) Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]GTP-gamma-S, binding in Chinese hamster ovarian (CHO) cells
- ChEMBL_105265 (CHEMBL872558) Binding affinity towards recombinant human melatonin receptor type 1B expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay
- ChEMBL_1499416 (CHEMBL3583851) Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy
- ChEMBL_105081 (CHEMBL711326) Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A
- ChEMBL_105099 (CHEMBL714106) Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.
- ChEMBL_105112 (CHEMBL715955) Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand
- ChEMBL_105097 (CHEMBL714104) Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
- ChEMBL_105261 (CHEMBL710751) Binding affinity for human Melatonin receptor type 1B stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand
- ChEMBL_105263 (CHEMBL715855) Binding affinity on human melatonin receptor type 1B stably transfected in human embryonic kidney (HEK 293) cells using 2-[125I]iodomelatonin as radioligand.
- ChEMBL_2026951 (CHEMBL4681109) Agonist activity at MT1 (unknown origin) expressed in HEK293T cells incubated for 15 mins by melatonin Gi/o-mediated cAMP inhibition GloSensor assay
- ChEMBL_2026952 (CHEMBL4681110) Agonist activity at MT2(unknown origin) expressed in HEK293T cells incubated for 15 mins by melatonin Gi/o-mediated cAMP inhibition GloSensor assay
- ChEMBL_1499414 (CHEMBL3583849) Agonist activity at human recombinant melatonin receptor-2 expressed in CHO cells assessed as decrease of cAMP level after 10 mins by HTRF assay
- ChEMBL_2228632 (CHEMBL5142145) Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
- ChEMBL_2228635 (CHEMBL5142148) Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
- Binding to Melatonin MT3 Binding Sites The experiment of binding to MT3 sites was carried out on hamster brain membranes using [125I]2-iodomelatonin as radioligand in accordance with the protocol described by Pickering, D. S et al. (Pickering, D. S et al, 1990, Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus, Eur J Pharmacol. 1990 Jan. 3; 175(1):71-7).
- ChEMBL_2228633 (CHEMBL5142146) Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
- ChEMBL_2228636 (CHEMBL5142149) Displacement of 2-[125I]iodomelatonin from human melatonin MT2 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
- ChEMBL_2228637 (CHEMBL5142150) Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
- ChEMBL_2228641 (CHEMBL5142154) Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
- ChEMBL_2228638 (CHEMBL5142151) Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
- ChEMBL_2228642 (CHEMBL5142155) Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay