CHEBI:11684 REVERSE TRIIODOTHYRONINE BDBM50103763 Reverse Tri-Iodothyronine
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- Su, DS; Lim, JJ; Tinney, E; Tucker, TJ; Saggar, S; Sisko, JT; Wan, BL; Young, MB; Anderson, KD; Rudd, D; Munshi, V; Bahnck, C; Felock, PJ; Lu, M; Lai, MT; Touch, S; Moyer, G; Distefano, DJ; Flynn, JA; Liang, Y; Sanchez, R; Perlow-Poehnelt, R; Miller, M; Vacca, JP; Williams, TM; Anthony, NJ Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif. Bioorg Med Chem Lett 20: 4328-32 (2010)
- Hopkins, AL; Ren, J; Esnouf, RM; Willcox, BE; Jones, EY; Ross, C; Miyasaka, T; Walker, RT; Tanaka, H; Stammers, DK; Stuart, DI Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J Med Chem 39: 1589-600 (1996)
- Kang, D; Fang, Z; Li, Z; Huang, B; Zhang, H; Lu, X; Xu, H; Zhou, Z; Ding, X; Daelemans, D; De Clercq, E; Pannecouque, C; Zhan, P; Liu, X Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles. J Med Chem 59: 7991-8007 (2016)
- Viira, B; Selyutina, A; García-Sosa, AT; Karonen, M; Sinkkonen, J; Merits, A; Maran, U Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem 24: 2519-29 (2016)
- Wei, L; Wang, HL; Huang, L; Chen, CH; Morris-Natschke, SL; Lee, KH; Xie, L Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus. Bioorg Med Chem Lett 27: 2788-2792 (2017)
- Kang, D; Zhang, H; Wang, Z; Zhao, T; Ginex, T; Luque, FJ; Yang, Y; Wu, G; Feng, D; Wei, F; Zhang, J; De Clercq, E; Pannecouque, C; Chen, CH; Lee, KH; Murugan, NA; Steitz, TA; Zhan, P; Liu, X Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. J Med Chem 62: 1484-1501 (2019)
- Kroeger Smith, MB; Hose, BM; Hawkins, A; Lipchock, J; Farnsworth, DW; Rizzo, RC; Tirado-Rives, J; Arnold, E; Zhang, W; Hughes, SH; Jorgensen, WL; Michejda, CJ; Smith, RH Molecular modeling calculations of HIV-1 reverse transcriptase nonnucleoside inhibitors: correlation of binding energy with biological activity for novel 2-aryl-substituted benzimidazole analogues. J Med Chem 46: 1940-7 (2003)
- Tang, J; Do, HT; Huber, AD; Casey, MC; Kirby, KA; Wilson, DJ; Kankanala, J; Parniak, MA; Sarafianos, SG; Wang, Z Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker. Eur J Med Chem 166: 390-399 (2019)
- Cantrell, AS; Engelhardt, P; Hogberg, M; Jaskunas, SR; Johansson, NG; Jordan, CL; Kangasmetsa, J; Kinnick, MD; Lind, P; Morin, JM; Muesing, MA; Noreen, R; Oberg, B; Pranc, P; Sahlberg, C; Ternansky, RJ; Vasileff, RT; Vrang, L; West, SJ; Zhang, H Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs. J Med Chem 39: 4261-74 (1996)
- Deng, BL; Hartman, TL; Buckheit, RW; Pannecouque, C; De Clercq, E; Cushman, M Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents. J Med Chem 49: 5316-23 (2006)
- Masuda, N; Yamamoto, O; Fujii, M; Ohgami, T; Fujiyasu, J; Kontani, T; Moritomo, A; Orita, M; Kurihara, H; Koga, H; Kageyama, S; Ohta, M; Inoue, H; Hatta, T; Shintani, M; Suzuki, H; Sudo, K; Shimizu, Y; Kodama, E; Matsuoka, M; Fujiwara, M; Yokota, T; Shigeta, S; Baba, M Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives. Bioorg Med Chem 13: 949-61 (2005)
- Sakamoto, T; Cullen, MD; Hartman, TL; Watson, KM; Buckheit, RW; Pannecouque, C; De Clercq, E; Cushman, M Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems. J Med Chem 50: 3314-21 (2007)
- Genin, MJ; Poel, TJ; Yagi, Y; Biles, C; Althaus, I; Keiser, BJ; Kopta, LA; Friis, JM; Reusser, F; Adams, WJ; Olmsted, RA; Voorman, RL; Thomas, RC; Romero, DL Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs. J Med Chem 39: 5267-75 (1997)
- Pontikis, R; Dollé, V; Guillaumel, J; Dechaux, E; Note, R; Nguyen, CH; Legraverend, M; Bisagni, E; Aubertin, AM; Grierson, DS; Monneret, C Synthesis and evaluation of"AZT-HEPT","AZT-pyridinone", and"ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase. J Med Chem 43: 1927-39 (2000)
- Genin, MJ; Poel, TJ; May, PD; Kopta, LA; Yagi, Y; Olmsted, RA; Friis, JM; Voorman, RL; Adams, WJ; Thomas, RC; Romero, DL Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution. J Med Chem 42: 4140-9 (1999)
- Morningstar, ML; Roth, T; Farnsworth, DW; Smith, MK; Watson, K; Buckheit, RW; Das, K; Zhang, W; Arnold, E; Julias, JG; Hughes, SH; Michejda, CJ Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme. J Med Chem 50: 4003-4015 (2007)
- Tucker, TJ; Saggar, S; Sisko, JT; Tynebor, RM; Williams, TM; Felock, PJ; Flynn, JA; Lai, MT; Liang, Y; McGaughey, G; Liu, M; Miller, M; Moyer, G; Munshi, V; Perlow-Poehnelt, R; Prasad, S; Sanchez, R; Torrent, M; Vacca, JP; Wan, BL; Yan, Y The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. Bioorg Med Chem Lett 18: 2959-66 (2008)
- Hogberg, M; Sahlberg, C; Engelhardt, P; Noreen, R; Kangasmetsa, J; Johansson, NG; Oberg, B; Vrang, L; Zhang, H; Sahlberg, BL; Unge, T; Lovgren, S; Fridborg, K; Backbro, K Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. J Med Chem 42: 4150-60 (1999)
- Billamboz, M; Bailly, F; Lion, C; Calmels, C; Andréola, ML; Witvrouw, M; Christ, F; Debyser, Z; De Luca, L; Chimirri, A; Cotelle, P 2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4. Eur J Med Chem 46: 535-46 (2011)
- He, Y; Chen, F; Sun, G; Wang, Y; De Clercq, E; Balzarini, J; Pannecouque, C 5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series. Bioorg Med Chem Lett 14: 3173-6 (2004)
- Carlsson, J; Boukharta, L; Aqvist, J Combining docking, molecular dynamics and the linear interaction energy method to predict binding modes and affinities for non-nucleoside inhibitors to HIV-1 reverse transcriptase. J Med Chem 51: 2648-56 (2008)
- Gao, P; Cheng, X; Sun, L; Song, S; Álvarez, M; Luczkowiak, J; Pannecouque, C; De Clercq, E; Menéndez-Arias, L; Zhan, P; Liu, X Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase. Bioorg Med Chem 27: 3836-3845 (2019)
- Radi, M; Maga, G; Alongi, M; Angeli, L; Samuele, A; Zanoli, S; Bellucci, L; Tafi, A; Casaluce, G; Giorgi, G; Armand-Ugon, M; Gonzalez, E; Esté, JA; Baltzinger, M; Bec, G; Dumas, P; Ennifar, E; Botta, M Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. J Med Chem 52: 840-51 (2009)
- Bonache, MC; Chamorro, C; Velázquez, S; De Clercq, E; Balzarini, J; Barrios, FR; Gago, F; Camarasa, MJ; San-Félix, A Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position. J Med Chem 48: 6653-60 (2005)
- Mertens, A; Zilch, H; Konig, B; Schafer, W; Poll, T; Kampe, W; Seidel, H; Leser, U; Leinert, H Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity. J Med Chem 36: 2526-35 (1993)
- Kang, D; Fang, Z; Huang, B; Lu, X; Zhang, H; Xu, H; Huo, Z; Zhou, Z; Yu, Z; Meng, Q; Wu, G; Ding, X; Tian, Y; Daelemans, D; De Clercq, E; Pannecouque, C; Zhan, P; Liu, X Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants. J Med Chem 60: 4424-4443 (2017)
- Wai, JS; Williams, TM; Bamberger, DL; Fisher, TE; Hoffman, JM; Hudcosky, RJ; MacTough, SC; Rooney, CS; Saari, WS; Thomas, CM Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one. J Med Chem 36: 249-55 (1993)
- Tucker, TJ; Lyle, TA; Wiscount, CM; Britcher, SF; Young, SD; Sanders, WM; Lumma, WC; Goldman, ME; Oamppound39Brien, JA; Ball, RG Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4-dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. J Med Chem 37: 2437-44 (1994)
- Deng, BL; Zhao, Y; Hartman, TL; Watson, K; Buckheit, RW; Pannecouque, C; De Clercq, E; Cushman, M Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem 44: 1210-4 (2009)
- Fournier, JF; Clary, L; Chambon, S; Dumais, L; Harris, CS; Millois, C; Pierre, R; Talano, S; Thoreau, É; Aubert, J; Aurelly, M; Bouix-Peter, C; Brethon, A; Chantalat, L; Christin, O; Comino, C; El-Bazbouz, G; Ghilini, AL; Isabet, T; Lardy, C; Luzy, AP; Mathieu, C; Mebrouk, K; Orfila, D; Pascau, J; Reverse, K; Roche, D; Rodeschini, V; Hennequin, LF J Med Chem 61: 4030-4051 (2018)
- HIV-1 Reverse Transcriptase Assay Biological assay using HIV-1 reverse transcriptase.
- ChEMBL_2297017 Inhibition of HIV1 reverse transcriptase
- ChEMBL_2455766 Inhibition of HIV1 reverse transcriptase
- ChEBML_195046 Inhibition of HIV-1 reverse transcriptase.
- ChEBML_195047 Inhibition of HIV-1 reverse transcriptase
- ChEMBL_1454137 (CHEMBL3362904) Inhibition of HIV reverse transcriptase
- ChEMBL_1513506 (CHEMBL3611932) Inhibition of HIV1 reverse transcriptase
- ChEMBL_1548831 (CHEMBL3755387) Inhibition of HIV1 reverse transcriptase
- ChEMBL_1769203 (CHEMBL4221315) Inhibition of HIV1 reverse transcriptase
- ChEMBL_1795839 (CHEMBL4267956) Inhibition of HIV1 reverse transcriptase
- ChEMBL_1891828 (CHEMBL4393749) Inhibition of HIV1 reverse transcriptase
- ChEMBL_196523 (CHEMBL801069) Therapeutic concentration on reverse transcriptase
- ChEMBL_2201577 (CHEMBL5114285) Inhibition of HIV1 reverse transcriptase
- ChEMBL_2300485 Inhibition of HIV-1 reverse transcriptase
- ChEMBL_2379323 Inhibition of HIV-1 reverse transcriptase
- ChEMBL_2484947 Inhibition of HIV-1 reverse transcriptase
- ChEMBL_307251 (CHEMBL829157) Inhibitory concentration against Reverse transcriptase
- ChEMBL_329788 (CHEMBL854379) Inhibition of HIV reverse transcriptase
- ChEMBL_356306 (CHEMBL868183) Inhibition of HIV reverse transcriptase
- ChEMBL_370933 (CHEMBL867243) Inhibition of HIV1 reverse transcriptase
- ChEMBL_377007 (CHEMBL867399) Inhibition of HIV reverse transcriptase
- ChEMBL_427529 (CHEMBL912179) Inhibition of HIV1 reverse transcriptase
- ChEMBL_437168 (CHEMBL906565) Inhibition of HIV1 reverse transcriptase
- ChEMBL_440584 (CHEMBL888533) Inhibition of HIV1 reverse transcriptase
- ChEMBL_446085 (CHEMBL895180) Inhibition of HIV1 reverse transcriptase
- ChEMBL_465754 (CHEMBL948998) Inhibition of HIV1 reverse transcriptase
- ChEMBL_475592 (CHEMBL934598) Inhibition of HIV1 reverse transcriptase
- ChEMBL_480449 (CHEMBL941104) Inhibition of HIV1 reverse transcriptase
- ChEMBL_484679 (CHEMBL1011363) Inhibition of HIV1 reverse transcriptase
- ChEMBL_502585 (CHEMBL988396) Inhibition of HIV1 reverse transcriptase
- ChEMBL_502847 (CHEMBL984036) Inhibition of HIV1 reverse transcriptase
- ChEMBL_502868 (CHEMBL987578) Inhibition of HIV1 reverse transcriptase
- ChEMBL_521749 (CHEMBL1005039) Inhibition of HIV1 reverse transcriptase
- ChEMBL_532747 (CHEMBL972321) Inhibition of HIV1 reverse transcriptase
- ChEMBL_545024 (CHEMBL1016320) Inhibition of HIV1 reverse transcriptase
- ChEMBL_545624 (CHEMBL1033264) Inhibition of HIV1 reverse transcriptase
- ChEMBL_561277 (CHEMBL1016225) Inhibition of HIV1 reverse transcriptase
- ChEMBL_601565 (CHEMBL1047745) Inhibition of HIV1 reverse transcriptase
- ChEMBL_629799 (CHEMBL1115617) Inhibition of HIV1 reverse transcriptase
- ChEMBL_642450 (CHEMBL1177406) Inhibition of HIV1 reverse transcriptase
- ChEMBL_701790 (CHEMBL1656927) Inhibition of HIV1 reverse transcriptase
- ChEMBL_715432 (CHEMBL1664817) Inhibition of HIV1 reverse transcriptase
- ChEMBL_718271 (CHEMBL1679575) Inhibition of HIV1 reverse transcriptase
- ChEMBL_950883 (CHEMBL2349707) Inhibition of HIV1 reverse transcriptase
- ChEBML_195059 Inhibition of recombinant HIV-1 reverse transcriptase
- ChEBML_195198 Concentration required to inhibit HIV reverse transcriptase
- ChEBML_195201 Inhibition of HIV-1 recombinant reverse transcriptase
- ChEBML_195511 Inhibitory activity against HIV-1 reverse transcriptase
- ChEBML_196935 Inhibition of purified HIV-2 reverse transcriptase
- ChEBML_80142 Inhibitory activity against HIV-1 reverse transcriptase
- ChEBML_80143 Inhibitory activity against HIV-1 reverse transcriptase
- ChEMBL_1763342 (CHEMBL4198589) Inhibition of HIV1 reverse transcriptase polymerase
- ChEMBL_1875049 (CHEMBL4376338) Inhibition of HIV-1 reverse transcriptase
- ChEMBL_195046 (CHEMBL800346) Inhibition of HIV-1 reverse transcriptase.
- ChEMBL_195047 (CHEMBL800347) Inhibition of HIV-1 reverse transcriptase
- ChEMBL_195058 (CHEMBL797513) Inhibition of HIV-1 reverse transcriptase.
- ChEMBL_197282 (CHEMBL804269) Inhibition of HIV-1 reverse transcriptase.
- ChEMBL_305018 (CHEMBL829452) Inhibitory concentration against HIV-Reverse transcriptase
- ChEMBL_331788 (CHEMBL864673) Inhibitory activity against AMV Reverse transcriptase
- ChEMBL_386501 (CHEMBL870409) Inhibition of recombinant HIV1 reverse transcriptase
- ChEMBL_439842 (CHEMBL890163) Inhibition of HIV1 recombinant reverse transcriptase
- ChEMBL_553446 (CHEMBL957139) Inhibition of HIV1 recombinant reverse transcriptase
- ChEMBL_559681 (CHEMBL1010079) Inhibition of HIV1 3B reverse transcriptase
- ChEMBL_721311 (CHEMBL1675423) Binding affinity to HIV1 reverse transcriptase
- ChEMBL_740785 (CHEMBL1763886) Inhibition of HIV-1 reverse transcriptase
- ChEMBL_985351 (CHEMBL2432160) Inhibition of HIV-1 reverse transcriptase
- ChEBML_195505 Inhibition of purified recombinant HIV-1 reverse transcriptase
- ChEBML_196792 Ability to inhibit simian sarcoma virus reverse transcriptase
- ChEBML_28873 Inhibitor of avian myeloblastosis virus AMV reverse transcriptase
- ChEBML_80096 Inhibitory activity against HIV reverse transcriptase (HIV RT)
- ChEBML_80145 Tested for the inhibition towards HIV-reverse transcriptase
- ChEBML_80267 Inhibitory activity against reverse transcriptase of HIV-1
- ChEMBL_1763343 (CHEMBL4198590) Inhibition of HIV1 reverse transcriptase RNase H
- ChEMBL_1769208 (CHEMBL4221320) Inhibition of HIV1 reverse transcriptase p66/p51
- ChEMBL_195198 (CHEMBL798388) Concentration required to inhibit HIV reverse transcriptase
- ChEMBL_195201 (CHEMBL877837) Inhibition of HIV-1 recombinant reverse transcriptase
- ChEMBL_195344 (CHEMBL802586) Inhibitory activity against E138K mutant reverse transcriptase
- ChEMBL_195358 (CHEMBL802598) Inhibitory activity against HIV-1 Reverse transcriptase
- ChEMBL_195369 (CHEMBL802407) Inhibitory activity against HIV-1 reverse transcriptase
- ChEMBL_195370 (CHEMBL802408) Inhibitory activity against HIV-1 reverse transcriptase
- ChEMBL_195380 (CHEMBL802417) Inhibitory activity against R172A mutant reverse transcriptase
- ChEMBL_195512 (CHEMBL872992) Inhibitory activity against HIV-1 reverse transcriptase
- ChEMBL_195513 (CHEMBL800581) Inhibitory activity against HIV-1 reverse transcriptase
- ChEMBL_195660 (CHEMBL800044) Inhibitory concentration required against Reverse transcriptase (RT)
- ChEMBL_195839 (CHEMBL799138) Inhibition of HIV-1 reverse transcriptase (RT)
- ChEMBL_195845 (CHEMBL799144) Inhibition of HIV-1 reverse transcriptase (P236L)
- ChEMBL_196368 (CHEMBL806001) Inhibitory activity against HIV-2 reverse transcriptase
- ChEMBL_196932 (CHEMBL803949) Inhibition of purified HIV-1 reverse transcriptase
- ChEMBL_196935 (CHEMBL803952) Inhibition of purified HIV-2 reverse transcriptase
- ChEMBL_197263 (CHEMBL804179) Effective concentration against HIV-1 reverse transcriptase
- ChEMBL_197283 (CHEMBL804270) Inhibitory concentration against HIV-1 reverse transcriptase
- ChEMBL_2321682 Inhibition of HIV-1 reverse transcriptase RNase H
- ChEMBL_2325943 Inhibition of wild type HIV-1 reverse transcriptase
- ChEMBL_2379331 Inhibition of HIV-1 reverse transcriptase RNase H
- ChEMBL_2494202 Inhibition of wild type HIV-1 reverse transcriptase
- ChEMBL_302539 (CHEMBL875215) Inhibitory constant against HIV-1 reverse transcriptase
- ChEMBL_305433 (CHEMBL830926) Inhibitory activity against HIV-1 reverse transcriptase
- ChEMBL_355438 (CHEMBL868998) Inhibition of HIV1 wild type Reverse Transcriptase
- ChEMBL_449954 (CHEMBL899059) Inhibition of HIV1 reverse transcriptase by ELISA
- ChEMBL_450286 (CHEMBL900567) Inhibition of HIV1 reverse transcriptase K103N mutant
- ChEMBL_450287 (CHEMBL900568) Inhibition of HIV1 reverse transcriptase L100I mutant
- ChEMBL_450288 (CHEMBL900569) Inhibition of HIV1 reverse transcriptase V106A mutant
- ChEMBL_450289 (CHEMBL900570) Inhibition of HIV1 reverse transcriptase V179D mutant
- ChEMBL_450291 (CHEMBL900572) Inhibition of HIV1 reverse transcriptase Y188L mutant
- ChEMBL_484694 (CHEMBL1014062) Inhibition of drug-resistant HIV1 reverse transcriptase
- ChEMBL_511945 (CHEMBL980033) Inhibition of HIV1 3B reverse transcriptase activity
- ChEMBL_541098 (CHEMBL1034081) Inhibition on HIV1 reverse transcriptase p66/p51
- ChEMBL_543621 (CHEMBL1011646) Activity at HIV1 non-nucleoside reverse transcriptase
- ChEMBL_545205 (CHEMBL1018956) Inhibition of wild-type HIV1 reverse transcriptase
- ChEMBL_552634 (CHEMBL957279) Inhibition of HIV1 virion-associated reverse transcriptase
- ChEMBL_564789 (CHEMBL954255) Inhibition of HIV1 reverse transcriptase p66/p51
- ChEMBL_601566 (CHEMBL1047746) Inhibition of wild-type HIV1 reverse transcriptase
- ChEMBL_601567 (CHEMBL1047747) Inhibition of HIV1 reverse transcriptase Y181C mutant
- ChEMBL_601568 (CHEMBL1047748) Inhibition of HIV1 reverse transcriptase K103N mutant
- ChEMBL_601740 (CHEMBL1041647) Inhibition of wild type HIV1 reverse transcriptase
- ChEMBL_611354 (CHEMBL1073715) Inhibition of HIV1 reverse transcriptase by EIA
- ChEMBL_632040 (CHEMBL1110082) Inhibition of HIV1 reverse transcriptase by ELISA
- ChEMBL_675251 (CHEMBL1273233) Inhibition of wild type HIV1 reverse transcriptase
- ChEMBL_675253 (CHEMBL1273235) Inhibition of HIV1 reverse transcriptase L100I mutant
- ChEMBL_675254 (CHEMBL1273236) Inhibition of HIV1 reverse transcriptase V106A mutant
- ChEMBL_675255 (CHEMBL1273237) Inhibition of HIV1 reverse transcriptase Y188L mutant
- ChEMBL_712672 (CHEMBL1660415) Inhibition of wild-type HIV1 Reverse transcriptase
- ChEMBL_712673 (CHEMBL1660416) Inhibition of HIV1 Reverse transcriptase P119S mutant
- ChEMBL_712674 (CHEMBL1660417) Inhibition of HIV1 Reverse transcriptase T165A mutant
- ChEMBL_712675 (CHEMBL1660418) Inhibition of HIV1 Reverse transcriptase M184V mutant
- ChEMBL_734864 (CHEMBL1693126) Inhibition of HIV1 3B reverse transcriptase activity
- ChEMBL_750572 (CHEMBL1786436) Antiviral activity against HIV1 Reverse transcriptase activity
- ChEMBL_756682 (CHEMBL1805147) Inhibition of HIV1 wild type reverse transcriptase
- ChEMBL_756683 (CHEMBL1805148) Inhibition of HIV1 reverse transcriptase K103N mutant
- ChEMBL_756684 (CHEMBL1805149) Inhibition of HIV1 reverse transcriptase L100I mutant
- ChEMBL_756685 (CHEMBL1805150) Inhibition of HIV1 reverse transcriptase V179D mutant
- ChEMBL_770448 (CHEMBL1833757) Inhibition of wild type HIV1 reverse transcriptase
- ChEBML_140627 Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse transcriptase)
- ChEMBL_140629 (CHEMBL752874) Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in reverse transcriptase
- ChEBML_195502 Inhibitory activity against recombinant HIV-1 reverse transcriptase (rRT)
- ChEBML_196372 Inhibitory activity against HIV-1 reverse transcriptase was determined
- ChEMBL_1795808 (CHEMBL4267925) Inhibition of wild-type HIV1 3B reverse transcriptase
- ChEMBL_1795809 (CHEMBL4267926) Inhibition of recombinant HIV1 reverse transcriptase L100I mutant
- ChEMBL_1795810 (CHEMBL4267927) Inhibition of recombinant HIV1 reverse transcriptase K103N mutant
- ChEMBL_1795811 (CHEMBL4267928) Inhibition of recombinant HIV1 reverse transcriptase Y181C mutant
- ChEMBL_1795812 (CHEMBL4267929) Inhibition of recombinant HIV1 reverse transcriptase Y188L mutant
- ChEMBL_1900999 (CHEMBL4403221) Inhibition of wild type HIV-1 reverse transcriptase
- ChEMBL_1927894 (CHEMBL4430966) Inhibition of recombinant HIV1 non-nucleoside reverse transcriptase
- ChEMBL_195083 (CHEMBL797537) Inhibition of DNA synthesis by HIV reverse transcriptase
- ChEMBL_195367 (CHEMBL802405) Inhibitory activity against HIV-1 recombinant reverse transcriptase
- ChEMBL_195371 (CHEMBL802409) Inhibitory activity against HIV-1 reverse transcriptase (P236L)
- ChEMBL_195847 (CHEMBL799146) Inhibition of HIV-1 reverse transcriptase (wild type)
- ChEMBL_196044 (CHEMBL802221) Binding affinity against HIV reverse transcriptase (Estimated Ki)
- ChEMBL_196363 (CHEMBL805996) Inhibitory activity against HIV-reverse transcriptase (HIV-RT)
- ChEMBL_196364 (CHEMBL805997) Evaluated for inhibition of HIV-2 reverse transcriptase
- ChEMBL_197451 (CHEMBL804236) Evaluated for inhibition of HIV-1 reverse transcriptase
- ChEMBL_2195570 (CHEMBL5107930) Inhibition of HIV-1 reverse transcriptase Y181C mutant
- ChEMBL_2204934 (CHEMBL5117642) Inhibition of wild type HIV-1 Reverse transcriptase
- ChEMBL_2321701 Non-competitive inhibition of HIV reverse transcriptase polymerase activity
- ChEMBL_305327 (CHEMBL833548) Inhibitory concentration against HIV-1 virion reverse transcriptase
- ChEMBL_321537 (CHEMBL880597) Inhibition of recombinant HIV-1 reverse transcriptase activity
- ChEMBL_450285 (CHEMBL900566) Inhibition of wild type HIV1 3B reverse transcriptase
- ChEMBL_479604 (CHEMBL926800) Inhibition of HIV1 reverse transcriptase by SPA assay
- ChEMBL_516593 (CHEMBL988680) Inhibition of wild type HIV1 free reverse transcriptase
- ChEMBL_534522 (CHEMBL984612) Inhibition of HIV1 recombinant wild type reverse transcriptase
- ChEMBL_601741 (CHEMBL1041648) Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant
- ChEMBL_712676 (CHEMBL1660419) Inhibition of HIV1 Reverse transcriptase P119S/T165A mutant
- ChEMBL_712677 (CHEMBL1660420) Inhibition of HIV1 Reverse transcriptase P119S/M184V mutant
- ChEMBL_735834 (CHEMBL1694226) Inhibition of Human immunodeficiency virus 1 reverse transcriptase
- ChEMBL_756686 (CHEMBL1805151) Inhibition of HIV1 free wild type reverse transcriptase
- ChEMBL_756687 (CHEMBL1805152) Inhibition of HIV1 free reverse transcriptase K103N mutant
- ChEMBL_756688 (CHEMBL1805153) Inhibition of HIV1 free reverse transcriptase L100I mutant
- ChEMBL_756689 (CHEMBL1805154) Inhibition of HIV1 free reverse transcriptase V179D mutant
- ChEMBL_80145 (CHEMBL856189) Tested for the inhibition towards HIV-reverse transcriptase
- ChEMBL_820058 (CHEMBL2032831) Inhibition of HIV1 reverse transcriptase RNase H activity
- ChEMBL_828775 (CHEMBL2060425) Inhibition of Human immunodeficiency virus 1 reverse transcriptase
- ChEMBL_140627 (CHEMBL752872) Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse transcriptase)
- ChEMBL_140631 (CHEMBL752876) Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 with a Y181C mutation in RT (reverse transcriptase)
- ChEMBL_1982636 (CHEMBL4615898) Inhibition of HIV-1 reverse transcriptase His-tagged p51 heterodimerization with HIV-1 reverse transcriptase p66 incubated for 16 hrs by ELISA
- ChEBML_195359 Inhibitory activity against HIV-1 Reverse transcriptase (RT) was determined
- ChEMBL_164500 (CHEMBL771477) Inhibitory activity against HIV-1 reverse transcriptase (RT M184I)
- ChEMBL_164502 (CHEMBL771478) Inhibitory activity against HIV-1 reverse transcriptase (RT M184V)
- ChEMBL_195068 (CHEMBL797523) In vitro for inhibition of HIV-1 reverse transcriptase.
- ChEMBL_195079 (CHEMBL797533) In vitro for inhibition of HIV-1 reverse transcriptase.
- ChEMBL_195372 (CHEMBL802410) Inhibitory activity against HIV-1 reverse transcriptase (wild type)
- ChEMBL_195504 (CHEMBL798925) Inhibitory activity against wild-type HIV-1 reverse transcriptase
- ChEMBL_195518 (CHEMBL800586) Inhibitory activity against RAdT of HIV-1 Reverse transcriptase
- ChEMBL_195519 (CHEMBL800587) Inhibitory activity against rCdG of HIV-1 Reverse transcriptase
- ChEMBL_195846 (CHEMBL799145) inhibitory activity against HIV-1 reverse transcriptase (wild type
- ChEMBL_196348 (CHEMBL802044) Inhibition of HIV-1 reverse transcriptase (HIV-1 RT)
- ChEMBL_196378 (CHEMBL802550) Inhibitory activity against E233V mutant HIV-1 reverse transcriptase
- ChEMBL_196380 (CHEMBL802552) Inhibitory activity against L100I mutant HIV-1 reverse transcriptase
- ChEMBL_196382 (CHEMBL802554) Inhibitory activity against P236L mutant HIV-1 reverse transcriptase
- ChEMBL_196509 (CHEMBL798323) Inhibitory activity against Y181C mutant HIV-1 reverse transcriptase
- ChEMBL_196510 (CHEMBL798324) Inhibitory activity against Y188H mutant HIV-1 reverse transcriptase
- ChEMBL_196515 (CHEMBL798329) Antiviral activity was determined against HIV- 1 reverse transcriptase
- ChEMBL_197284 (CHEMBL804271) tested for its inhibition of HIV-1 reverse transcriptase.
- ChEMBL_2119941 (CHEMBL4829088) Inhibition of recombinant HIV1 reverse transcriptase by colorimetric assay
- ChEMBL_2321700 Inhibition of HIV-1 reverse transcriptase associated RNase H activity
- ChEMBL_2337386 Inhibition of HIV-1 reverse transcriptase expressed in Escherichia coli
- ChEMBL_305565 (CHEMBL828584) Inhibitory concentration against HIV-1 mutant reverse transcriptase (K103R)
- ChEMBL_305566 (CHEMBL827160) Inhibitory concentration against HIV-1 mutant reverse transcriptase (Y181C)
- ChEMBL_442659 (CHEMBL892828) Inhibition of HIV1 reverse transcriptase using Poly rC.dG template
- ChEMBL_442660 (CHEMBL892829) Inhibition of HIV1 reverse transcriptase using Poly rA.dT template
- ChEMBL_447797 (CHEMBL896806) Inhibition of HIV1 reverse transcriptase by scintillation proximity assay
- ChEMBL_532312 (CHEMBL973235) Inhibition of HIV1 reverse transcriptase in human LAI cells
- ChEMBL_543620 (CHEMBL1011645) Inhibition of HIV1 3B reverse transcriptase after 30 mins
- ChEMBL_546666 (CHEMBL1029194) Inhibition of HIV1 recombinant reverse transcriptase by UIC assay
- ChEMBL_546667 (CHEMBL1029195) Inhibition of HIV1 recombinant reverse transcriptase by NCI assay
- ChEMBL_583929 (CHEMBL1061780) Binding affinity to wild type HIV1 LAI reverse transcriptase
- ChEMBL_583930 (CHEMBL1061781) Binding affinity to HIV1 LAI reverse transcriptase M184V mutant
- ChEMBL_675614 (CHEMBL1273922) Inhibition of wild type HIV1 reverse transcriptase RNasH activity
- ChEMBL_712679 (CHEMBL1660422) Inhibition of HIV1 Reverse transcriptase P119S/T165A/M184V mutant
- ChEMBL_732391 (CHEMBL1690093) Mixed non-competitive inhibition of HIV1 reverse transcriptase activity
- ChEMBL_140625 (CHEMBL752870) Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutations in RT (reverse transcriptase)
- ChEMBL_140630 (CHEMBL752875) Inhibitory activity against non-nucleoside reverse transcriptase inhibitors (NNRTI) -resistant HIV-1 strain A17 variant with Y181C plus K103N mutations in RT (reverse transcriptase)
- ChEBML_195673 Tested for inhibitory concentration against HIV-1 non-nucleoside reverse transcriptase
- ChEBML_196945 Inhibition of HIV-1 reverse transcriptase from peripheral blood mononuclear cells.
- ChEBML_197275 In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant
- ChEBML_80097 The compound was tested for inhibitory activity against HIV reverse transcriptase
- ChEBML_80140 Compound was tested for the inhibition of HIV-1 reverse transcriptase
- ChEMBL_1795813 (CHEMBL4267930) Inhibition of recombinant HIV1 reverse transcriptase L100I/K103N double mutant
- ChEMBL_1795814 (CHEMBL4267931) Inhibition of recombinant HIV1 reverse transcriptase K103N/Y181C double mutant
- ChEMBL_1795840 (CHEMBL4267957) Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant
- ChEMBL_195341 (CHEMBL802583) Inhibition of HIV-1 reverse transcriptase at 37 degree Centigrade
- ChEMBL_195376 (CHEMBL802413) Inhibitory activity against K103N mutant of HIV-1 reverse transcriptase
- ChEMBL_196376 (CHEMBL802548) Inhibitory concentration against wild-type reverse transcriptase of HIV-1
- ChEMBL_196795 (CHEMBL802186) In vitro for inhibitory activity against HIV-1 Reverse Transcriptase
- ChEMBL_197265 (CHEMBL804181) Effective concentration required against L100I mutant HIV-1 reverse transcriptase
- ChEMBL_197270 (CHEMBL804185) Effective concentration required against wild type HIV-1 reverse transcriptase
- ChEMBL_197277 (CHEMBL804264) Inhibition of HIV-1 reverse transcriptase at 37 degree Centigrade
- ChEMBL_2215043 (CHEMBL5128175) Displacement of [8,5'-3H]dGTP from HIV-1 reverse transcriptase
- ChEMBL_2325942 Inhibition of HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase
- ChEMBL_2379326 Inhibition of HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase
- ChEMBL_2438499 Inhibition of HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase
- ChEMBL_305627 (CHEMBL828660) Inhibitory concentration against HIV-1 wild type reverse transcriptase (IIIB)
- ChEMBL_305759 (CHEMBL827097) Inhibitory concentration against HIV-1 mutant reverse transcriptase (K103N+Y181C)
- ChEMBL_306023 (CHEMBL833538) Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase
- ChEMBL_306024 (CHEMBL833539) Inhibitory concentration against human immunodeficiency virus type 1 reverse transcriptase
- ChEMBL_321370 (CHEMBL881514) Inhibitory concentration required to inhibit recombinant HIV-1 reverse transcriptase
- ChEMBL_321416 (CHEMBL881947) Inhibitory concentration against recombinant human immunodeficiency virus 1 reverse transcriptase
- ChEMBL_364650 (CHEMBL854191) Inhibition of wild type HIV1 reverse transcriptase in 293T cells
- ChEMBL_364651 (CHEMBL854193) Inhibition of HIV1 reverse transcriptase K103N mutant in 293T cells
- ChEMBL_364652 (CHEMBL854194) Inhibition of HIV1 reverse transcriptase Y181C mutant in 293T cells
- ChEMBL_364653 (CHEMBL854195) Inhibition of HIV1 reverse transcriptase Y188C mutant in 293T cells
- ChEMBL_378455 (CHEMBL871029) Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity
- ChEMBL_479605 (CHEMBL926801) Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assay
- ChEMBL_479606 (CHEMBL926802) Inhibition of HIV1 reverse transcriptase Y181C mutant by SPA assay
- ChEMBL_516594 (CHEMBL988681) Inhibition of wild type HIV1 reverse transcriptase-DNA binary complex
- ChEMBL_545941 (CHEMBL1024276) Inhibition of HIV1 reverse transcriptase after 1 hr by ELISA
- ChEMBL_658209 (CHEMBL1246601) Inhibition of HIV1 reverse transcriptase after 1 hr by ELISA
- ChEMBL_663847 (CHEMBL1250747) Inhibition of HIV1 DH012 reverse transcriptase by roche colorimetric assay
- ChEMBL_705547 (CHEMBL1661163) Inhibition of HIV1 isolate R8 reverse transcriptase after 90 mins
- ChEMBL_725038 (CHEMBL1678143) Inhibition of RNase H activity of HIV-2 reverse transcriptase
- ChEMBL_732389 (CHEMBL1690091) Inhibition of HIV1 reverse transcriptase activity by primer extension assay
- ChEMBL_732390 (CHEMBL1690092) Binding affinity to recombinant HIV1 reverse transcriptase by isothermal calorimetry
- ChEMBL_740498 (CHEMBL1764653) Inhibition of Human immunodeficiency virus 1 NL4.3 reverse transcriptase activity
- ChEMBL_755187 (CHEMBL1805966) Inhibition of wild type HIV1 reverse transcriptase by SPA assay
- ChEMBL_755188 (CHEMBL1805967) Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assay
- ChEMBL_755189 (CHEMBL1805968) Inhibition of HIV1 reverse transcriptase Y181C mutant by SPA assay
- ChEMBL_755374 (CHEMBL1804530) Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assay
- ChEMBL_820062 (CHEMBL2032835) Inhibition of HIV1 reverse transcriptase associated RNA dependent polymerase activity
- ChEMBL_1566184 (CHEMBL3788090) Inhibition of wild type HIV1 Reverse transcriptase assessed as reduction of biotin deoxyuridine triphosphate incorporation into the wild type HIV1 reverse transcriptase after 1 hr by ELISA
- PHENOSENSE assay The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs).
- ChEBML_195202 Concentration required for no significant inhibitory activity against HIV-1 reverse transcriptase
- ChEBML_195377 Inhibitory activity against K103N/Y181C double mutant of HIV-1 reverse transcriptase
- ChEBML_195520 Inhibitory activity against human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).
- ChEBML_195837 The compound was evaluated for the inhibition of HIV-1 reverse transcriptase
- ChEBML_197449 Compound was evaluated for enzymatic inhibitory activity against recombinant HIV reverse transcriptase
- ChEBML_80130 The compound was evaluated as inhibitor of recombinant HIV-l reverse transcriptase
- ChEBML_80151 Equilibrium binding constant at the active site of HIV-1 reverse transcriptase
- ChEBML_80573 Inhibitory activity was evaluated in vitro against HIV- I reverse transcriptase (RT)
- ChEMBL_1280542 (CHEMBL3096427) Inhibition of HIV-1 reverse transcriptase after 1 hr by spectrophotometry
- ChEMBL_1462916 (CHEMBL3399856) Inhibition of wild type HIV1 p66/p51 reverse transcriptase by spectrofluorometry
- ChEMBL_1542247 (CHEMBL3745469) Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assay
- ChEMBL_1900980 (CHEMBL4403202) Inhibition of HIV-1 reverse transcriptase after 1 hr by ELISA
- ChEMBL_1925210 (CHEMBL4428282) Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment
- ChEMBL_195526 (CHEMBL800593) Inhibitory concentration against HIV-1 reverse transcriptase in scintillation proximity assay
- ChEMBL_196192 (CHEMBL803637) Inhibitory activity against HIV-1 Reverse transcriptase wild-type (RT wt)
- ChEMBL_196512 (CHEMBL798326) Inhibitory activity against wild type HIV-1 reverse transcriptase (WT-RT)
- ChEMBL_196794 (CHEMBL799737) Ability to inhibit simian virus reverse transcriptase, expressed as log Ki.
- ChEMBL_196934 (CHEMBL803951) Inhibition of HIV-1 reverse transcriptase from peripheral blood mononuclear cells
- ChEMBL_196945 (CHEMBL801137) Inhibition of HIV-1 reverse transcriptase from peripheral blood mononuclear cells.
- ChEMBL_197264 (CHEMBL804180) Effective concentration of the compound against viral replication by Reverse transcriptase
- ChEMBL_197275 (CHEMBL804262) In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant
- ChEMBL_197276 (CHEMBL804263) In vitro antiviral activity against HIV-1 Reverse transcriptase wild type
- ChEMBL_2201739 (CHEMBL5114447) Inhibition of wild-type HIV-1 reverse transcriptase by Picogreen assay
- ChEMBL_2215045 (CHEMBL5128177) Inhibition of HIV-1 reverse transcriptase using rC.dG as primer/template
- ChEMBL_2344610 Inhibition of HIV-1 NL4-3 reverse transcriptase by RT-PCR analysis
- ChEMBL_2455768 Inhibition of HIV-1 NL4-3 reverse transcriptase by RT-PCR analysis
- ChEMBL_378454 (CHEMBL871028) Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization
- ChEMBL_449946 (CHEMBL899053) Binding affinity to HIV1 reverse transcriptase K103N mutant at 5 degC
- ChEMBL_449947 (CHEMBL899055) Binding affinity to HIV1 reverse transcriptase K103N mutant at 15 degC
- ChEMBL_449948 (CHEMBL899054) Binding affinity to HIV1 reverse transcriptase K103N mutant at 25 degC
- ChEMBL_449949 (CHEMBL899051) Binding affinity to HIV1 reverse transcriptase K103N mutant at 35 degC
- ChEMBL_449950 (CHEMBL899052) Binding affinity to HIV1 reverse transcriptase Y181C mutant at 5 degC
- ChEMBL_449951 (CHEMBL899056) Binding affinity to HIV1 reverse transcriptase Y181C mutant at 15 degC
- ChEMBL_449952 (CHEMBL899057) Binding affinity to HIV1 reverse transcriptase Y181C mutant at 25 degC
- ChEMBL_449953 (CHEMBL899058) Binding affinity to HIV1 reverse transcriptase Y181C mutant at 35 degC
- ChEMBL_465974 (CHEMBL947217) Inhibition of HIV1 reverse transcriptase K103N mutant by HeLa-MAGI assay
- ChEMBL_468352 (CHEMBL931815) Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells
- ChEMBL_489999 (CHEMBL984662) Inhibition of HIV1 reverse transcriptase by steady state nucleotide incorporation assay
- ChEMBL_516595 (CHEMBL988682) Inhibition of wild type HIV1 reverse transcriptase-DNA-dNTP ternary complex
- ChEMBL_583931 (CHEMBL1061782) Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y mutant
- ChEMBL_640765 (CHEMBL1175706) Inhibition of wild type HIV1 reverse transcriptase by SPA heteropolymeric assay
- ChEMBL_640767 (CHEMBL1175708) Inhibition of HIV1 reverse transcriptase Y188L mutant by SPA heteropolymeric assay
- ChEMBL_656649 (CHEMBL1245693) Inhibition of HIV1 Reverse transcriptase by primer extension-based scintillation assay
- ChEMBL_699570 (CHEMBL1647928) Inhibition of HIV1 reverse transcriptase activity after 1 hr by ELISA
- ChEMBL_817161 (CHEMBL2026077) Inhibition of HIV-1 reverse transcriptase after 1 hr by colorimetry
- ChEMBL_946838 (CHEMBL2345503) Inhibition of HIV1 reverse transcriptase after 1 hr by colorimetric assay
- Filter-based DNA Synthesis Inhibition Assay Inhibition assay using HIV-1 reverse transcriptase.
- ChEMBL_2503795 Inhibition of HIV1 reverse transcriptase using r(A)350 template and d(T)16 primer as substrate preincubated for 1 hr before adding substrate by PicoGreen EnzChek Reverse Transcriptase Assay
- ChEBML_195074 Compound was tested for inhibitory activity against HIV-1 wild type reverse transcriptase
- ChEMBL_1513515 (CHEMBL3611941) Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation
- ChEMBL_195377 (CHEMBL802414) Inhibitory activity against K103N/Y181C double mutant of HIV-1 reverse transcriptase
- ChEMBL_195507 (CHEMBL798928) Inhibitory activity of compound against reverse transcriptase (RT) in cell free RT.
- ChEMBL_195520 (CHEMBL800588) Inhibitory activity against human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).
- ChEMBL_195527 (CHEMBL800594) Inhibitory concentration against HIV-1 reverse transcriptase mutant (Tyr-181 to Cys)
- ChEMBL_195528 (CHEMBL800595) Inhibitory concentration against HIV-1 reverse transcriptase mutant (Tyr-181 to Leu)
- ChEMBL_195535 (CHEMBL800982) Inhibitory concentration against HIV-1 replication by interfering with virus reverse transcriptase
- ChEMBL_196184 (CHEMBL801172) In vitro inhibitory activity against HIV-1 wild type reverse transcriptase (RT)
- ChEMBL_196519 (CHEMBL798333) Inhibitory effect on Moloney Murine Leukemia virus (mo-MuLv) recombinant Reverse transcriptase
- ChEMBL_196520 (CHEMBL801067) Inhibitory effect on Moloney Murine Leukemia virus (mo-MuLv) recombinant reverse transcriptase
- ChEMBL_197448 (CHEMBL804233) Compound was evaluated for 50% inhibition of HIV-RT (HIV reverse transcriptase)
- ChEMBL_2231068 (CHEMBL5144840) Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation
- ChEMBL_2330867 Inhibition of HIV1 Reverse transcriptase incubated for 30 mins by fluorescence based analysis
- ChEMBL_304235 (CHEMBL829774) Concentration required to inhibit HIV-1 reverse transcriptase activity (wild-type) enzyme
- ChEMBL_447048 (CHEMBL897349) Inhibition of RNA dependent DNA polymerase activity of HIV1 recombinant reverse transcriptase
- ChEMBL_447798 (CHEMBL896807) Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant by scintillation proximity assay
- ChEMBL_503280 (CHEMBL991974) Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coli
- ChEMBL_583932 (CHEMBL1061783) Binding affinity to HIV1 LAI reverse transcriptase M41L/L210W/T215Y/M184V mutant
- ChEMBL_633210 (CHEMBL1118866) Inhibition of HIV1 reverse transcriptase-associated ribonuclease H activity by fluorescence assay
- ChEMBL_665357 (CHEMBL1261034) Inhibition of HIV1 recombinant wild type reverse transcriptase by SPA heteropolymeric assay
- ChEMBL_665359 (CHEMBL1261036) Inhibition of HIV1 recombinant reverse transcriptase Y188L mutant by SPA heteropolymeric assay
- ChEMBL_792578 (CHEMBL1930122) Inhibition of Human immunodeficiency virus reverse transcriptase K103N mutant by SPA assay
- ChEMBL_798903 (CHEMBL1943410) Inhibition of Human immunodeficiency virus reverse transcriptase K103N mutant by SPA assay
- ChEMBL_882099 (CHEMBL2214487) Inhibition of HIV1 reverse transcriptase incubated for 1 hr by colorimetric assay
- ChEMBL_972305 (CHEMBL2411981) Inhibition of HIV1 recombinant reverse transcriptase RNase H activity after 10 mins
- ChEBML_196960 Tested for the inhibition of HIV-1 reverse transcriptase using a ribosomal RNA template
- ChEBML_80607 Inhibition of recombinant reverse transcriptase (RT) in cell-free Quan-T-RT assay system
- ChEMBL_1350089 (CHEMBL3271625) Inhibition of HIV1 wild-type reverse transcriptase using [3H]dTTP by scintillation counting
- ChEMBL_1435796 (CHEMBL3389551) Inhibition of wild type HIV1 reverse transcriptase assessed as reduction in enzyme activity
- ChEMBL_195074 (CHEMBL872977) Compound was tested for inhibitory activity against HIV-1 wild type reverse transcriptase
- ChEMBL_195841 (CHEMBL799140) The compound was tested for inhibitory activity against Recombinant HIV-1 reverse transcriptase
- ChEMBL_195843 (CHEMBL799142) The quantity of compound required to reduce WT Reverse transcriptase activity by 50%
- ChEMBL_197122 (CHEMBL801612) Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay CEM-SS cells
- ChEMBL_197422 (CHEMBL799811) Ability to inhibit the HIV-1 reverse transcriptase in cord blood mononuclear cells.
- ChEMBL_197423 (CHEMBL799812) Ability to inhibit the HIV-1 reverse transcriptase in cord blood mononuclear cells.
- ChEMBL_197429 (CHEMBL802227) Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay in CEM-SS
- ChEMBL_197434 (CHEMBL802400) Antiviral activity was tested in cells acutely infected with HIV-1 Reverse transcriptase
- ChEMBL_2278447 Binding affinity to HIV-1 reverse transcriptase assessed as dissociation constant by SPR analysis
- ChEMBL_304234 (CHEMBL829773) Concentration required to inhibit HIV-1 reverse transcriptase activity (wild-type) by 50%
- ChEMBL_310375 (CHEMBL834370) Concentration required to inhibit HIV-1 reverse transcriptase activity (wild-type) by 50%
- ChEMBL_310383 (CHEMBL833564) Concentration required to inhibit HIV-1 reverse transcriptase activity of wild-type enzyme
- ChEMBL_461924 (CHEMBL944771) Inhibition of HIV NL43 recombinant reverse transcriptase K103N mutant by scintillation proximity assay
- ChEMBL_542167 (CHEMBL1010774) Inhibition of polymerase activity of HIV1 recombinant reverse transcriptase expressed in Escherichia coli
- ChEMBL_640766 (CHEMBL1175707) Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant by SPA heteropolymeric assay
- ChEMBL_717874 (CHEMBL1670582) Inhibition of recombinant HIV-1 reverse transcriptase RNase H domain after 10 mins
- ChEMBL_718270 (CHEMBL1679574) Binding affinity to HIV1 reverse transcriptase by surface plasmon resonance based biosensor assay
- ChEMBL_732403 (CHEMBL1690218) Inhibition of HIV1 HXB2 reverse transcriptase K103N mutant activity by primer extension assay
- Reverse Transcriptase Assay The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. The substrate-incorporated radioactivity was quantitated by scintillation counting.
- ChEBML_195055 Compound was evaluated for the 50% inhibitory concentration on human immunodeficiency virus associated reverse transcriptase
- ChEBML_195663 Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rA)-oligo(dT) template primer
- ChEBML_195690 The compound was evaluated for inhibition of HIV-1 mutant GluL38-Lys recombinant reverse transcriptase
- ChEMBL_1281238 (CHEMBL3100973) Inhibition of wild-type HIV1 reverse transcriptase assessed as incorporation of biotin-labeled dUTP
- ChEMBL_1339445 (CHEMBL3243838) Inhibition of wild-type HIV1 reverse transcriptase p66/p51 after 40 mins by spectrophotometry
- ChEMBL_1451901 (CHEMBL3363071) Inhibition of HIV-1 reverse transcriptase after 1 hr by ELISA plate reader analysis
- ChEMBL_1467610 (CHEMBL3411706) Inhibition of HIV1 reverse transcriptase-associated RNA-dependent DNA polymerase activity after 30 mins
- ChEMBL_1795826 (CHEMBL4267943) Inhibition of CXCR4 tropic HIV1 3B reverse transcriptase infected in human TZM-bl cells
- ChEMBL_1795827 (CHEMBL4267944) Inhibition of CXCR4 tropic HIV1 UG070 reverse transcriptase infected in human TZM-bl cells
- ChEMBL_1795828 (CHEMBL4267945) Inhibition of CCR5 tropic HIV1 ADA5 reverse transcriptase infected in human TZM-bl cells
- ChEMBL_1795829 (CHEMBL4267946) Inhibition of CCR5 tropic HIV1 VB59 reverse transcriptase infected in human TZM-bl cells
- ChEMBL_195070 (CHEMBL797525) Compound was tested for inhibitory activity against HIV-1 mutant type reverse transcriptase (K103N)
- ChEMBL_195071 (CHEMBL797526) Compound was tested for inhibitory activity against HIV-1 mutant type reverse transcriptase (L1001)
- ChEMBL_195072 (CHEMBL797527) Compound was tested for inhibitory activity against HIV-1 mutant type reverse transcriptase (P236L)
- ChEMBL_195073 (CHEMBL797528) Compound was tested for inhibitory activity against HIV-1 mutant type reverse transcriptase (Y181C)
- ChEMBL_195678 (CHEMBL800750) Inhibition of HIV-1 reverse transcriptase polymerization using wild type HIV-1-RT enzyme
- ChEMBL_195844 (CHEMBL799143) antiviral activity in Human immunodeficiency virus-1 as reverse transcriptase activity in culture supernatant
- ChEMBL_197123 (CHEMBL801613) Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay in CEM-SS cells
- ChEMBL_197430 (CHEMBL802228) Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase assay in CEM-SS cells
- ChEMBL_197433 (CHEMBL802399) Antiviral activity was tested in cells acutely infected with HIV-1 RT (reverse transcriptase)
- ChEMBL_197436 (CHEMBL878543) Compound concentration that causes 50 % inhibition of HIV-1 peptide-derived reverse transcriptase (RT)
- ChEMBL_2219398 (CHEMBL5132732) Inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assay
- ChEMBL_2281181 Inhibition of HIV-1 reverse transcriptase incubated for 90 mins by liquid scintillation counting analysis
- ChEMBL_2309714 Inhibition of wild-type HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation
- ChEMBL_427350 (CHEMBL909270) Inhibition of reverse transcriptase activity in HIV1 NL4-3 infected MT4 cells after dialysis
- ChEMBL_427351 (CHEMBL909271) Inhibition of reverse transcriptase activity in HIV1 NL4-3 infected MT4 cells before dialysis
- ChEMBL_471467 (CHEMBL938149) Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assay
- ChEMBL_516592 (CHEMBL988679) Binding affinity to HIV1 reverse transcriptase treated for 3 mins by surface plasmon resonance
- ChEMBL_516596 (CHEMBL988683) Inhibition of HIV1 recombinant free reverse transcriptase K103N mutant expressed in Escherichia coli BL21
- ChEMBL_591809 (CHEMBL1041549) Inhibition of HIV1 reverse transcriptase p66/p51 using poly(rC)-oligo)dG) as template
- ChEMBL_609017 (CHEMBL1074497) Inhibition of HIV1 reverse transcriptase L100I mutant by RNA-dependent DNA polymerase activity assay
- ChEMBL_609018 (CHEMBL1074498) Inhibition of HIV1 reverse transcriptase Y181I mutant by RNA-dependent DNA polymerase activity assay
- ChEMBL_609019 (CHEMBL1074499) Inhibition of HIV1 reverse transcriptase K103N mutant by RNA-dependent DNA polymerase activity assay
- ChEMBL_665358 (CHEMBL1261035) Inhibition of HIV1 recombinant reverse transcriptase K103N/Y181C double mutant by SPA heteropolymeric assay
- ChEMBL_743750 (CHEMBL1767564) Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 mins
- ChEMBL_743751 (CHEMBL1767565) Inhibition of HIV-1 reverse transcriptase K101E mutant-mediated polymerization reaction after 30 mins
- ChEMBL_743752 (CHEMBL1767610) Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 mins
- ChEMBL_756690 (CHEMBL1805155) Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA binary complex
- ChEMBL_756691 (CHEMBL1805156) Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA binary complex
- ChEMBL_756692 (CHEMBL1805157) Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA binary complex
- ChEMBL_756693 (CHEMBL1805158) Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA binary complex
- ChEMBL_80607 (CHEMBL690000) Inhibition of recombinant reverse transcriptase (RT) in cell-free Quan-T-RT assay system
- ChEMBL_806932 (CHEMBL1959233) Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 reverse transcriptase
- ChEMBL_806936 (CHEMBL1959237) Inhibition of ribonuclease H activity of wild type Human immunodeficiency virus 1 reverse transcriptase
- ChEMBL_806937 (CHEMBL1959238) Inhibition of ribonuclease H activity of Human immunodeficiency virus 1 reverse transcriptase Lys103Asn mutant
- ChEMBL_827266 (CHEMBL2050665) Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study
- ChEMBL_827269 (CHEMBL2050668) Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics study
- ChEMBL_1350090 (CHEMBL3271626) Inhibition of HIV1 wild-type reverse transcriptase K103N mutant using [3H]dTTP by scintillation counting
- ChEMBL_1350092 (CHEMBL3271628) Inhibition of HIV1 wild-type reverse transcriptase L1001 mutant using [3H]dTTP by scintillation counting
- ChEMBL_1350093 (CHEMBL3271629) Inhibition of HIV1 wild-type reverse transcriptase V106A mutant using [3H]dTTP by scintillation counting
- ChEMBL_1435797 (CHEMBL3389552) Inhibition of wild type HIV1 reverse transcriptase K103N mutant assessed as reduction in enzyme activity
- ChEMBL_1435799 (CHEMBL3389554) Inhibition of wild type HIV1 reverse transcriptase L100I mutant assessed as reduction in enzyme activity
- ChEMBL_1435800 (CHEMBL3389555) Inhibition of wild type HIV1 reverse transcriptase V106A mutant assessed as reduction in enzyme activity
- ChEMBL_1435801 (CHEMBL3389556) Inhibition of wild type HIV1 reverse transcriptase Y181I mutant assessed as reduction in enzyme activity
- ChEMBL_1443743 (CHEMBL3371716) Inhibition of HIV-1 recombinant reverse transcriptase after 1 hr by streptavidinalkaline phosphatase reporter system
- ChEMBL_1467609 (CHEMBL3411705) Inhibition of HIV1 reverse transcriptase-associated DNA polymerase-independent RNase H activity after 1 hr
- ChEMBL_1891830 (CHEMBL4393751) Inhibition of HIV1 reverse transcriptase derived from HIV patient plasma by LC/MS/MS analysis
- ChEMBL_195663 (CHEMBL800047) Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rA)-oligo(dT) template primer
- ChEMBL_195664 (CHEMBL800048) Inhibitory effect on HIV-1 reverse transcriptase activity using poly(rC)-oligo(dG) template primer
- ChEMBL_195666 (CHEMBL800661) Inhibition of Reverse transcriptase (P236L) using poly(rA)600:oligo(dT)10 as template primer.
- ChEMBL_195667 (CHEMBL800662) Inhibition of Reverse transcriptase (Wild Type) with poly(rA)600:oligo(dT)10 template primer
- ChEMBL_195668 (CHEMBL800663) Inhibition of Reverse transcriptase (Y181C) using poly(rA)600:oligo(dT)10 as template primer.
- ChEMBL_195688 (CHEMBL800605) The 50% inhibitory concentration was measured as inhibition of Ribonuclease H activity of reverse transcriptase
- ChEMBL_195690 (CHEMBL800607) The compound was evaluated for inhibition of HIV-1 mutant GluL38-Lys recombinant reverse transcriptase
- ChEMBL_197121 (CHEMBL801611) Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase (RT) assay in CEM-SS cells.
- ChEMBL_197424 (CHEMBL799813) Activity of selected HIV-1 N-acylthiocarbamates in enzyme assay against Virion-Associated reverse transcriptase
- ChEMBL_197428 (CHEMBL802226) Antiviral activity against Human Immunodeficiency Virus by Reverse transcriptase (RT) assay in CEM-SS cells
- ChEMBL_197432 (CHEMBL802398) Antiviral activity was evaluated by Reverse transcriptase activity in cells acutely infected with HIV-1
- ChEMBL_2311795 Inhibition of HIV-1 reverse transcriptase using [2,8-3H]dGTP as substrate by fluorescence based assay
- ChEMBL_638659 (CHEMBL1168190) Inhibition of HIV 3B reverse transcriptase using [3H]TTP as a tracer by scintillation counting
- ChEMBL_705571 (CHEMBL1661187) Inhibition of HIV1 isolate R8 reverse transcriptase Y181C mutant after 90 mins by electrochemiluminescence analysis
- ChEMBL_705572 (CHEMBL1661188) Inhibition of HIV1 isolate R8 reverse transcriptase K103N mutant after 90 mins by electrochemiluminescence analysis
- ChEMBL_756694 (CHEMBL1805159) Inhibition of HIV1 wild type reverse transcriptase/poly(rA)/oligo(dT) DNA/dTTP ternary complex
- ChEMBL_756695 (CHEMBL1805160) Inhibition of HIV1 reverse transcriptase K103N mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complex
- ChEMBL_756696 (CHEMBL1805161) Inhibition of HIV1 reverse transcriptase L100I mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complex
- ChEMBL_756697 (CHEMBL1805162) Inhibition of HIV1 reverse transcriptase V179D mutant/poly(rA)/oligo(dT) DNA/dTTP ternary complex
- ChEMBL_768443 (CHEMBL1832162) Inhibition of wild-type HIV1 subtype B reverse transcriptase assessed as incorporation of [3H]dTTP
- ChEMBL_79626 (CHEMBL693712) Cross Resistance (antiviral activity) with V108I (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate v
- ChEBML_197268 Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 7 in the article)
- ChEMBL_1276841 (CHEMBL3089582) Binding affinity to HIV1 reverse transcriptase assessed as compound incorporation into DNA by primer extension assay
- ChEMBL_1435798 (CHEMBL3389553) Inhibition of wild type HIV1 reverse transcriptase Y181I/Y181C mutant assessed as reduction in enzyme activity
- ChEMBL_1467613 (CHEMBL3411709) Inhibition of HIV1 reverse transcriptase Tyr181Cys mutant-associated RNA-dependent DNA polymerase activity after 30 mins
- ChEMBL_1467615 (CHEMBL3411711) Inhibition of HIV1 reverse transcriptase Lys103Asn mutant-associated RNA-dependent DNA polymerase activity after 30 mins
- ChEMBL_1565176 (CHEMBL3782568) Inhibition of HIV1 reverse transcriptase using DIG-labeled dNTPs as substrate after 1 hr by ELISA
- ChEMBL_1801099 (CHEMBL4273391) Inhibition of HIV1 reverse transcriptase RNaseH activity using 3'-fluorescein/5'-Dabcyl labeled HTS-1 substrate
- ChEMBL_1891833 (CHEMBL4393754) Inhibition of wild type recombinant HIV1 reverse transcriptase using poly(rA)-oligo(dT) as template/primer
- ChEMBL_195836 (CHEMBL799135) The compound was evaluated for inhibition of HIV-1 wild types GluL38-Lys recombinant reverse transcriptase
- ChEMBL_196042 (CHEMBL802219) Binding affinity towards L100I mutant HIV-1 reverse transcriptase (as per ref 10 in the article)
- ChEMBL_196043 (CHEMBL802220) Binding affinity towards wild type HIV-1 reverse transcriptase (as per ref 10 in the article)
- ChEMBL_197278 (CHEMBL804265) Inhibition of HIV-1 reverse transcriptase using a poly(rC):oligo(dG)12-18 template primer
- ChEMBL_197431 (CHEMBL802397) Antiviral activity was evaluated by RT (reverse transcriptase) activity in cells acutely infected with HIV-1
- ChEMBL_2201744 (CHEMBL5114452) Inhibition of HIV-1 reverse transcriptase preincubated for 45 mins followed by substrate addition by immunoassay
- ChEMBL_2485584 Inhibition of recombinant wild-type HIV-1 reverse transcriptase incubated for 40 mins by fluorescence based assay
- ChEMBL_304323 (CHEMBL829295) Effective concentration towards HIV-1 wild type reverse transcriptase activity by 50% measured in cellular assay
- ChEMBL_471469 (CHEMBL938151) Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assay
- ChEMBL_482407 (CHEMBL966000) Inhibition of HIV1 recombinant reverse transcriptase expressed in Escherichia coli using poly(dC)-oligo(dG) template
- ChEMBL_487139 (CHEMBL1022720) Inhibition of HIV1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rA)-oligo(dT) template
- ChEMBL_487140 (CHEMBL1022721) Inhibition of HIV1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rC)-oligo(dG) template
- ChEMBL_487141 (CHEMBL1022722) Inhibition of HIV1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rU)-oligo(dA) template
- ChEMBL_487142 (CHEMBL1022724) Inhibition of HIV1 recombinant reverse transcriptase expressed in Escherichia coli using poly(rG)-oligo(dC) template
- ChEMBL_490001 (CHEMBL984664) Inhibition of HIV1 reverse transcriptase M41L/D67N/L210W/T215Y mutant by steady state nucleotide incorporation assay
- ChEMBL_501126 (CHEMBL978904) Inhibition of recombinant HIV1 reverse transcriptase in cell free Quan-T-RT by scintillation proximity assay
- ChEMBL_516597 (CHEMBL988684) Inhibition of HIV1 recombinant reverse transcriptase K103N mutant-DNA binary complex expressed in Escherichia coli BL21
- ChEMBL_619113 (CHEMBL1102820) Inhibition of HIV1 reverse transcriptase expressed in human MT4 cells after 72 hrs by spread assay
- ChEMBL_699967 (CHEMBL1646374) Inhibition RNase H activity of HIV1 reverse transcriptase expressed in Escherichia coli stain BL21(DE3)pLysS
- ChEMBL_768876 (CHEMBL1831952) Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA
- ChEMBL_805873 (CHEMBL1960054) Inhibition of HIV1 reverse transcriptase assessed as incorporation of biotin-dUTP into poly(rA)-oligo(dT)
- ChEMBL_806933 (CHEMBL1959234) Inhibition of RNA-dependent DNA polymerase activity of wild type Human immunodeficiency virus 1 reverse transcriptase
- ChEMBL_806934 (CHEMBL1959235) Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 reverse transcriptase Lys103Asn mutant
- ChEMBL_939436 (CHEMBL2327819) Inhibition of wild type HIV-1 reverse transcriptase knuckles site after 30 mins by fluorescence assay
- ChEMBL_1278689 (CHEMBL3095867) Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin dUTP incorporation by primer extension assay
- ChEMBL_1279770 (CHEMBL3095331) Inhibition of recombinant HIV1 reverse transcriptase using poly rA:dT as template/primer after 1 hr by ELISA
- ChEMBL_1293405 (CHEMBL3122428) Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotinylated dUTP incorporation after 1 hr by ELISA
- ChEMBL_1454138 (CHEMBL3362905) Inhibition of HIV1 recombinant wild type reverse transcriptase p66/p51 using dsDNA by microplate reader based assay
- ChEMBL_1467612 (CHEMBL3411708) Inhibition of HIV1 reverse transcriptase Tyr181Cys mutant-associated DNA polymerase-independent RNase H activity after 1 hr
- ChEMBL_1467614 (CHEMBL3411710) Inhibition of HIV1 reverse transcriptase Lys103Asn mutant-associated DNA polymerase-independent RNase H activity after 1 hr
- ChEMBL_1501272 (CHEMBL3587981) Inhibition of wild-type HIV1 Reverse transcriptase p66/p51 assessed as relative fluorescence signal after 40 mins
- ChEMBL_195077 (CHEMBL797531) Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.
- ChEMBL_195204 (CHEMBL798996) HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTP
- ChEMBL_195842 (CHEMBL799141) The percent reduction of the reverse transcriptase (RT) activity in HIV-1/MN-infected MT-2 cells.
- ChEMBL_196053 (CHEMBL802885) In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution K103N
- ChEMBL_196180 (CHEMBL804953) In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution L100I
- ChEMBL_196181 (CHEMBL807530) In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution V106A
- ChEMBL_196182 (CHEMBL801170) In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y181I
- ChEMBL_196183 (CHEMBL801171) In vitro inhibitory activity against HIV-1 mutant Reverse transcriptase containing the single amino acid substitution Y188L
- ChEMBL_196194 (CHEMBL803639) The compound was tested for the inhibition of human immunodeficiency virus-1 reverse transcriptase(HIV-1 RT).
- ChEMBL_196375 (CHEMBL802547) Inhibitory concentration against wild type HIV-1/138Lys reverse transcriptase (RT) using [3H]dGTP as a radioligand
- ChEMBL_197124 (CHEMBL801614) Effective concentration that reduces HIV-induced cytopathic effect by 50% was determined by reverse transcriptase (RT) assay.
- ChEMBL_197266 (CHEMBL804182) Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 12 in the article)
- ChEMBL_197267 (CHEMBL804183) Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 6 in the article)
- ChEMBL_197268 (CHEMBL804184) Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 7 in the article)
- ChEMBL_197269 (CHEMBL877731) Effective concentration required against L100I mutant HIV-1 reverse transcriptase (as per ref 8 in the article)
- ChEMBL_197271 (CHEMBL804186) Effective concentration required against wild type HIV-1 reverse transcriptase (as per ref 12 in the article)
- ChEMBL_197272 (CHEMBL802509) Effective concentration required against wild type HIV-1 reverse transcriptase (as per ref 6 in the article)
- ChEMBL_197273 (CHEMBL804260) Effective concentration required against wild type HIV-1 reverse transcriptase (as per ref 7 in the article)
- ChEMBL_197274 (CHEMBL804261) Effective concentration required against wild type HIV-1 reverse transcriptase (as per ref 8 in the article)
- ChEMBL_2125951 (CHEMBL4835296) Inhibition of recombinant wild type HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into template
- ChEMBL_2201730 (CHEMBL5114438) Inhibition of recombinant HIV-1 reverse transcriptase using ABTS as substrate incubated for 1 hr by ELISA
- ChEMBL_2322215 Inhibition of wild type HIV-1 reverse transcriptase assessed as inhibition of biotin deoxyuridine triphosphate incorporation into protein
- ChEMBL_385312 (CHEMBL869229) Inhibition of recombinant HIV1 reverse transcriptase measured as inhibition of incorporation of [32P]GTP in rCDG primer
- ChEMBL_490007 (CHEMBL984670) Binding affinity to ternary complex of HIV1 reverse transcriptase with primer/template in presence of dCTP substrate
- ChEMBL_516598 (CHEMBL988685) Inhibition of HIV1 recombinant reverse transcriptase K103N mutant-DNA-dNTP ternary complex expressed in Escherichia coli BL21
- ChEMBL_579309 (CHEMBL1054760) Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand
- ChEMBL_579310 (CHEMBL1054761) Inhibition of HIV1 reverse transcriptase K103N mutant assessed as 32P-labeled GMP incorporation into nascent DNA strand
- ChEMBL_609013 (CHEMBL1073155) Inhibition of RNA-dependent DNA polymerase activity of HIV1 reverse transcriptase using poly(rA)/pligo(dT) template
- ChEMBL_619115 (CHEMBL1102822) Inhibition of HIV1 reverse transcriptase Y181C mutant in human MT4 cells after 72 hrs by spread assay
- ChEMBL_722005 (CHEMBL1675620) Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase G190A mutant by filter-based filtration assay
- ChEMBL_722006 (CHEMBL1675621) Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase Y181C mutant by filter-based filtration assay
- ChEMBL_769639 (CHEMBL1833572) Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into enzyme by colorimetry
- ChEMBL_939432 (CHEMBL2327815) Inhibition of wild type HIV-1 reverse transcriptase 507 site incubated after 30 mins by fluorescence assay
- ChEMBL_947897 (CHEMBL2343640) Inhibition of HIV-1 reverse transcriptase assessed as decrease in incorporation of [3H]TTP into polyA template
- ChEMBL_950904 (CHEMBL2349977) Inhibition of HIV 1 reverse transcriptase assessed as incorporation of biotin-dUTP into poly rA.dT by ELISA
- ChEMBL_989993 (CHEMBL2447598) Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotinylated dUTP incorporation after 1 hr by ELISA
- ChEBML_195054 Compound was evaluated for its inhibitory activity against recombinant HIV-1 Reverse transcriptase using cell free RT inhibition assay
- ChEBML_195675 Tested for its ability to inhibit HIV-1 reverse transcriptase polymerization using A17 double mutant HIV-1-RT enzyme
- ChEMBL_1276474 (CHEMBL3088598) Inhibition of RNase H activity of recombinant HIV1 reverse transcriptase using poly(dC)-[3H]poly(rG) as substrate
- ChEMBL_1795818 (CHEMBL4267935) Inhibition of HIV1 reverse transcriptase K103N mutant infected in human MT4 cells harboring GFP by scanning microscopic analysis
- ChEMBL_1795820 (CHEMBL4267937) Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT4 cells harboring GFP by scanning microscopic analysis
- ChEMBL_1891834 (CHEMBL4393755) Inhibition of wild type recombinant HIV1 reverse transcriptase Y181C mutant using poly(rA)-oligo(dT) as template/primer
- ChEMBL_1932801 (CHEMBL4478453) Inhibition of RNase H activity of full length HIV1 reverse transcriptase using RNA-DNA duplex HTS-1 substrate
- ChEMBL_196374 (CHEMBL873105) Inhibitory concentration against wild type HIV-1 reverse transcriptase (RT) using poly rC.dG as the template or primer
- ChEMBL_2028543 (CHEMBL4682701) Inhibition of HIV-1BH10 reverse transcriptase expressed in Escherichia coli assessed as polymerization by real time FRET assay
- ChEMBL_2320625 Inhibition of HIV-1 reverse transcriptase incubated for 1 hrs in presence of biotin-labeled dNTPs by ELISA assay
- ChEMBL_2488968 Inhibition of wild-type HIV-1 reverse transcriptase incubated for 1 hr in presence of biotin-dUTP by ELISA
- ChEMBL_427347 (CHEMBL909267) Inhibition of reverse transcriptase activity in HIV1 infected HeLa-MAGI cells at 37 deg C after 48 hrs
- ChEMBL_539719 (CHEMBL1031568) Inhibition of DNA dependent DNA polymerase activity of HIV1 reverse transcriptase Y181C mutant expressed in Escherichia coli BL21
- ChEMBL_543748 (CHEMBL1020339) Inhibition of HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli using calf thymus DNA substrate
- ChEMBL_630077 (CHEMBL1109997) Inhibition of biotin-dUTP labeled HIV-1 reverse transcriptase after 30 mins colorimetric streptavidin alkaline phosphatase reporter system
- ChEMBL_734861 (CHEMBL1693123) Inhibition of HIV1 3B reverse transcriptase activity infected in human H9 cells assessed as level of p24 antigen
- ChEMBL_758401 (CHEMBL1811267) Inhibition of HIV1 reverse transcriptase assessed as residual enzyme activity at 50 uM after 1 hr by ELISA
- ChEMBL_768886 (CHEMBL1832053) Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA
- ChEMBL_806931 (CHEMBL1959154) Inhibition of ribonuclease H activity of HIV1 reverse transcriptase using as poly(dC)-[3H]poly(rG) as substrate
- ChEMBL_823533 (CHEMBL2045976) Inhibition of HIV1 reverse transcriptase using poly(ra)/oligo(dT)15 homopolymer template as substrate after 1 hr
- ChEMBL_911152 (CHEMBL3057813) Inhibition of wild type Human immunodeficiency virus 1 reverse transcriptase after 30 min by fluorescence microplate reader analysis
- ChEMBL_939435 (CHEMBL2327818) Inhibition of wild type HIV-1 reverse transcriptase incoming nucleotide binding site after 30 mins by fluorescence assay
- ChEMBL_949008 (CHEMBL2342760) Non-competitive inhibition of wild type HIV1 reverse transcriptase p66/p51 after 30 mins by liquid scintillation counting
- HIV-1 Reverse Transcriptase Assay IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extension assay. EC50s were obtained from inhibition of virus-induced cell-death in MT-4 cells.
- ChEBML_197421 Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of tritiated thymidine triphosphate onto a biotinylated rN.dN template primer
- ChEMBL_1448873 (CHEMBL3375075) Inhibition of purified recombinant HIV-1 reverse transcriptase after 1 hr using biotin-labeled dUTP by digoxigenin-peroxidase assay
- ChEMBL_1499865 (CHEMBL3583197) Inhibition of RNase H function of HIV1 reverse transcriptase using DNA/RNA hybrid as substrate by fluorescence spectrometer analysis
- ChEMBL_1784955 (CHEMBL4256472) Inhibition of wild-type HIV1 reverse transcriptase infected in human MT4 cells assessed as reduction in biotin-dUTP incorporation
- ChEMBL_1795817 (CHEMBL4267934) Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells harboring GFP by scanning microscopic analysis
- ChEMBL_1899208 (CHEMBL4401323) Inhibition of HIV1 reverse transcriptase RNase H expressed in Escherichia coli JM109 using RNA/DNA duplex substrate HTS-1
- ChEMBL_1906077 (CHEMBL4408435) Inhibition of recombinant HIV-1 reverse transcriptase p66/p51 incubated for 40 mins by picogreen dye based spectrofluorometric assay
- ChEMBL_195054 (CHEMBL798358) Compound was evaluated for its inhibitory activity against recombinant HIV-1 Reverse transcriptase using cell free RT inhibition assay
- ChEMBL_195675 (CHEMBL800748) Tested for its ability to inhibit HIV-1 reverse transcriptase polymerization using A17 double mutant HIV-1-RT enzyme
- ChEMBL_195681 (CHEMBL800598) Tested for its ability to inhibit HIV-1 reverse transcriptase strand transfer using wild type HIV-1-RT enzyme
- ChEMBL_196516 (CHEMBL798330) Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)
- ChEMBL_196517 (CHEMBL798331) Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)
- ChEMBL_2224845 (CHEMBL5138358) Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assay
- ChEMBL_2224846 (CHEMBL5138359) Inhibition of HIV-1 reverse transcriptase K103N mutant assessed as reduction in luciferase reporter activity by single-round assay
- ChEMBL_2224847 (CHEMBL5138360) Inhibition of HIV-1 reverse transcriptase E138K mutant assessed as reduction in luciferase reporter activity by single-round assay
- ChEMBL_2224848 (CHEMBL5138361) Inhibition of HIV-1 reverse transcriptase Y181C mutant assessed as reduction in luciferase reporter activity by single-round assay
- ChEMBL_2224849 (CHEMBL5138362) Inhibition of HIV-1 reverse transcriptase Y188L mutant assessed as reduction in luciferase reporter activity by single-round assay
- ChEMBL_2317478 Inhibition of wild type HIV-1 reverse transcriptase RNase-associated RNase H activity using RNA/DNA template-primer as substrate
- ChEMBL_2345375 Inhibition of wild type HIV-1 reverse transcriptase assessed as assessed as inhibition of biotin deoxyuridine triphosphate incorporation into protein
- ChEMBL_471453 (CHEMBL952768) Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assay
- ChEMBL_79484 (CHEMBL689897) Cross Resistance (antiviral activity) with 4xAZT (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79618 (CHEMBL693547) Cross Resistance (antiviral activity) with A98G (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79619 (CHEMBL693548) Cross Resistance (antiviral activity) with K101E (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79620 (CHEMBL693549) Cross Resistance (antiviral activity) with K103N (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79621 (CHEMBL693550) Cross Resistance (antiviral activity) with L100I (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79623 (CHEMBL693709) Cross Resistance (antiviral activity) with L74V (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79624 (CHEMBL693710) Cross Resistance (antiviral activity) with V106A (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79625 (CHEMBL693711) Cross Resistance (antiviral activity) with V108I (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79627 (CHEMBL693713) Cross Resistance (antiviral activity) with V179D (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79628 (CHEMBL884232) Cross Resistance (antiviral activity) with Y181C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79629 (CHEMBL693714) Cross Resistance (antiviral activity) with Y188C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79630 (CHEMBL693715) Cross Resistance (antiviral activity) with Y181C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79632 (CHEMBL695506) Cross Resistance (antiviral activity) with A98G (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79633 (CHEMBL695507) Cross Resistance (antiviral activity) with K101E (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_968173 (CHEMBL2399276) Inhibition of HIV1 reverse transcriptase using poly(rA)/oligo(dT)15 as substrate after 60 mins by fluorescence assay
- Enzyme Inhibition Assay The assay is based on a sandwich-ELISA protocol employing the ROCHE colorimetric reverse transcriptase kit (cat # 1468120910).
- ChEBML_196366 Compound was evaluated for inhibition of HIV-2 reverse transcriptase using rC.dG and [3H]-dGTP as substrates at 100 ug/mL
- ChEMBL_1558481 (CHEMBL3773516) Inhibition of recombinant HIV-1 reverse transcriptase using 234 nt long RNA template after 10 mins by liquid scintillation analysis
- ChEMBL_1795819 (CHEMBL4267936) Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells harboring GFP by scanning microscopic analysis
- ChEMBL_1801100 (CHEMBL4273392) Inhibition of HIV1 reverse transcriptase polymerase activity using 18 nucleotide DNA primer and 100 nucleotide DNA template after 30 mins
- ChEMBL_1849538 (CHEMBL4350079) Binding affinity to recombinant wild-type full length HIV1 reverse transcriptase p66/p51 expressed in Escherichia coli by biolayer interferometry
- ChEMBL_1855821 (CHEMBL4356550) Inhibition of recombinant wild type HIV1 reverse transcriptase p66/p51 incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_1862051 (CHEMBL4362907) Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into template incubated for 1 hr by ELISA
- ChEMBL_1869038 (CHEMBL4370104) Inhibition of recombinant HIV1 reverse transcriptase using (DIG)-dUTP and biotin-labeled dNTPs as substrate after 1 hr by ELISA
- ChEMBL_195679 (CHEMBL800596) Tested for its ability to inhibit HIV-1 reverse transcriptase strand transfer using A17 double mutant HIV-1-RT enzyme
- ChEMBL_197125 (CHEMBL803726) Reverse transcriptase activity was measured in the culture supernatant, concentration that reduces by 50% the HIV produced in the supernatant.
- ChEMBL_197420 (CHEMBL799809) Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of tritiated thymidine triphosphate onto a biotinylated rA.dT template primer
- ChEMBL_197421 (CHEMBL799810) Ability to inhibit HIV-1 IIIB reverse transcriptase catalyzed incorporation of tritiated thymidine triphosphate onto a biotinylated rN.dN template primer
- ChEMBL_2079300 (CHEMBL4735091) Inhibition of HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into template incubated for 1 hr by ELISA
- ChEMBL_2100865 (CHEMBL4809261) Inhibition of HIV-1 p66/p51 reverse transcriptase L100I mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_2100866 (CHEMBL4809262) Inhibition of HIV-1 p66/p51 reverse transcriptase K103N mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_2100867 (CHEMBL4809263) Inhibition of HIV-1 p66/p51 reverse transcriptase Y181C mutant incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_2100870 (CHEMBL4809266) Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_2157173 (CHEMBL5041833) Inhibition of wild type HIV-1 reverse transcriptase using biotin-labelled dNTPs as substrate incubated for 2 hrs by ELISA
- ChEMBL_2160236 (CHEMBL5044986) Inhibition of recombinant wild type p66/p51 HIV1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_2438483 Inhibition of recombinant HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase activity incubated for 30 mins by liquid scintillation method
- ChEMBL_317566 (CHEMBL825231) Effective concentration of the compound towards HIV-1 K103N/Y181C mutant reverse transcriptase activity by 50% measured in cellular assay
- ChEMBL_484391 (CHEMBL955364) Inhibition of DNA dependent DNA polymerase activity of HIV1 BH10 recombinant reverse transcriptase p66/p51 assessed as residual enzyme activity
- ChEMBL_539716 (CHEMBL1031565) Inhibition of RNA dependent DNA polymerase activity of HIV1 BH10 recombinant reverse transcriptase p66/p51 assessed as residual enzyme activity
- ChEMBL_539717 (CHEMBL1031566) Inhibition of DNA dependent DNA polymerase activity of HIV1 BH10 recombinant reverse transcriptase p66/p51 assessed as residual enzyme activity
- ChEMBL_666602 (CHEMBL1263762) Inhibition of RNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by filter-based filtration assay
- ChEMBL_666603 (CHEMBL1263763) Inhibition of RNA-dependent DNA polymerase activity of HIV1 subtype B reverse transcriptase M230L mutant by filter-based filtration assay
- ChEMBL_79485 (CHEMBL689898) Cross Resistance (antiviral activity) with 4xAZT/L100I (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_79486 (CHEMBL689899) Cross Resistance (antiviral activity) with 4xAZT/Y181C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_886109 (CHEMBL2210031) Inhibition of HIV1 recombinant reverse transcriptase assessed as incorporation of biotin-dUTP into poly(rC)-oligo(dG) by colorimetric analysis
- ChEMBL_939437 (CHEMBL2327820) Inhibition of wild type HIV-1 reverse transcriptase p66/p51 NNRTI adjacent binding site after 30 mins by fluorescence assay
- ChEMBL_1463321 (CHEMBL3399548) Inhibition of HIV1 reverse transcriptase L100I mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463322 (CHEMBL3399549) Inhibition of HIV1 reverse transcriptase K103N mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463323 (CHEMBL3399550) Inhibition of HIV1 reverse transcriptase V106A mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463324 (CHEMBL3399551) Inhibition of HIV1 reverse transcriptase Y181C mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1463325 (CHEMBL3399552) Inhibition of HIV1 reverse transcriptase G190A mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1626013 (CHEMBL3868482) Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT2 cells assessed as protection against viral infection by MTT assay
- ChEMBL_1763340 (CHEMBL4198587) Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assay
- ChEMBL_1795837 (CHEMBL4267954) Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytopathic effect
- ChEMBL_1801106 (CHEMBL4273398) Inhibition of recombinant HIV1 reverse transcriptase RNase H expressed in Escherichia coli JM109 using RNA/DNA duplex substrate HTS1 as substrate
- ChEMBL_1867169 (CHEMBL4368144) Inhibition of HIV1 reverse transcriptase Y181C/K103N double mutant infected in human MT4 cells assessed as reduction in virus-induced cytopathogenicity
- ChEMBL_196365 (CHEMBL805998) Compound was evaluated for inhibition of HIV-2 reverse transcriptase using rC.dG and [3H]-dGTP as substrates at 100 ug/ml
- ChEMBL_196366 (CHEMBL805999) Compound was evaluated for inhibition of HIV-2 reverse transcriptase using rC.dG and [3H]-dGTP as substrates at 100 ug/mL
- ChEMBL_197452 (CHEMBL804237) Compound was evaluated for inhibition of HIV-1 reverse transcriptase using rC.dG and [3H]dGTP as substrates at 100 ug/ml
- ChEMBL_197453 (CHEMBL804238) Compound was evaluated for inhibition of HIV-1 reverse transcriptase using rC.dG and [3H]dGTP as substrates at 100 ug/mL
- ChEMBL_2104796 (CHEMBL4813299) Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into cDNA measured after 1 hr by ELISA
- ChEMBL_2226856 (CHEMBL5140369) Inhibition of recombinant wild-type p66/p51 HIV-1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
- ChEMBL_490747 (CHEMBL994471) Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as incorporation of radioactive dTTP into poly(rA)/oligo(DT)
- ChEMBL_499472 (CHEMBL1018501) Inhibition of HIV1 recombinant reverse transcriptase assessed as incorporation of [32P]GTP into poly(rC).oligo(dG) (rCdG) homopolymer template primer
- ChEMBL_508433 (CHEMBL1001303) Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in presence of Mg2+ ions by band shift assay
- ChEMBL_508434 (CHEMBL1001304) Binding affinity to HIV1 reverse transcriptase p66/p51-polypurine tract primer complex in absence of Mg2+ ions by band shift assay
- ChEMBL_642255 (CHEMBL1177074) Inhibition of HIV1 reverse transcriptase-mediated thymidine incorporation into D23/D36 primer-template preincubated for 15 mins by polyacrylamide gel-electrophoresis
- ChEMBL_666605 (CHEMBL1263765) Inhibition of DNA-dependent DNA polymerase activity of wild type HIV1 subtype B reverse transcriptase by gel-based primer extension assay
- ChEMBL_666606 (CHEMBL1263766) Inhibition of DNA-dependent DNA polymerase activity of HIV1 subtype B reverse transcriptase M230L mutant by gel-based primer extension assay
- ChEMBL_722008 (CHEMBL1675623) Inhibition of Human immunodeficiency virus 1 subtype B reverse transcriptase DNA-dependent DNA polymerase activity by gel-based primer extension assay
- ChEMBL_822365 (CHEMBL2038743) Inhibition of HIV1 wildtype reverse transcriptase using poly(rA)/oligo(dT)15 as template by colometric streptavidin alkaline phosphate reporter assay
- ChEMBL_854340 (CHEMBL2154560) Inhibition of wild type HIV1 reverse transcriptase activity using poly (rA)/oligo (dT)15 homopolymer template after 1 hr by ELISA
- Quantitative Reverse Transcriptase Assay We used quantitative reverse-transcriptase PCR to measure the RNA levels of certain AMP genes (lysozyme, gallerimycin, moricin and cecropin) in caterpillars of M. sexta and the greater waxmoth G. mellonella challenged with Serratia entomophila or Salmonella enterica, respectively, following injection of different urea lipid compounds.
- ChEMBL_1463326 (CHEMBL3399553) Inhibition of HIV1 reverse transcriptase K103N/Y181C mutant using radioactively-labeled [alpha-32P]ATP substrate and activated DNA as template-primer complex
- ChEMBL_1518191 (CHEMBL3619838) Inhibition of recombinant HIV1 Reverse transcriptase p66/p51 using poly (rA)-oligo (dT) as template primer after 40 mins by spectrofluorometric analysis
- ChEMBL_1575430 (CHEMBL3802512) Inhibition of HIV1 wild type reverse transcriptase p66/p51 using poly(rA) template and measured after 40 mins by picogreen based spectrofluorometry
- ChEMBL_1784956 (CHEMBL4256473) Inhibition of HIV1 reverse transcriptase K103N mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay
- ChEMBL_1784957 (CHEMBL4256474) Inhibition of HIV1 reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay
- ChEMBL_1784958 (CHEMBL4256475) Inhibition of HIV1 reverse transcriptase L100I mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay
- ChEMBL_1784959 (CHEMBL4256476) Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay
- ChEMBL_1784960 (CHEMBL4256477) Inhibition of HIV1 reverse transcriptase Y188L mutant infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay
- ChEMBL_1795803 (CHEMBL4267920) Inhibition of HIV1 LAI reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1795823 (CHEMBL4267940) Inhibition of HIV1 3B reverse transcriptase infected in human MT2 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1885886 (CHEMBL4387468) Inhibition of HIV1 reverse transcriptase RNase H activity expressed in Escherichia coli using 32P-labeled template 31Trna RNA and DNA oligonucleotide 21P
- ChEMBL_1925207 (CHEMBL4428279) Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS1 substrate
- ChEMBL_197262 (CHEMBL804178) Cross Resistance (antiviral activity) with NL4-3(WT) NNRTI (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_2123611 (CHEMBL4832844) Inhibition of wild type HIV1 reverse transcriptase assessed as reduction in biotin-dUTP incorporation into protein incubated for 1 hrs by ELISA
- ChEMBL_2222731 (CHEMBL5136065) Inhibition of HIV-1 reverse transcriptase using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorometric analysis
- ChEMBL_2321675 Inhibition of recombinant HIV-1 reverse transcriptase associated RNA-dependent DNA polymerase activity incubated for 30 mins by multilabel counter plate reader analysis
- ChEMBL_2321688 Inhibition of HIV-1 reverse transcriptase associated RNase H using 5-GTTTTCTTTTCCCCCCTGAC-3 Fluorescein/5CAAAAGAAAAGGGGGGACUG-3-Dabcyl as substrate incubated for 1 hr
- ChEMBL_2438485 Inhibition of N-terminal 6-his-tagged HIV-1 reverse transcriptase RNase H (427 to 560 residues) transfected in Escherichia coli BL21 (DE3)
- ChEMBL_471455 (CHEMBL952770) Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assay
- ChEMBL_80139 (CHEMBL692750) Compound was tested for its inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.
- ChEMBL_1338882 (CHEMBL3240120) Inhibition of recombinant HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation in to poly [A] x oligo[dT]15 by ELISA
- ChEMBL_1450642 (CHEMBL3362706) Inhibition of wild type HIV1 reverse transcriptase assessed as inhibition of DNA primer extension using [8-3H(N)]-dATP by scintillation proximity assay
- ChEMBL_1473739 (CHEMBL3418256) Inhibition of Moloney murine leukemia virus reverse transcriptase polymerase activity using Td100/Pd18 DNA-DNA substrate incubated for 30 mins by fluorescence assay
- ChEMBL_1626014 (CHEMBL3868483) Inhibition of HIV1 reverse transcriptase K103N/Y181C double mutant infected in human MT2 cells assessed as protection against viral infection by MTT assay
- ChEMBL_1763341 (CHEMBL4198588) Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting method
- ChEMBL_1784950 (CHEMBL4256467) Inhibition of wild-type HIV1 3B reverse transcriptase infected in human MT4 cells assessed as protection against virus-induced cytotoxicity by MTT assay
- ChEMBL_1795804 (CHEMBL4267921) Inhibition of HIV1 reverse transcriptase L100I mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1795805 (CHEMBL4267922) Inhibition of HIV1 reverse transcriptase K103N mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1795806 (CHEMBL4267923) Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1795807 (CHEMBL4267924) Inhibition of HIV1 reverse transcriptase Y188L mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1795824 (CHEMBL4267941) Inhibition of HIV1 reverse transcriptase Y181C mutant infected in human MT2 cells assessed as protection against virus-induced cytopathic effect by MTT assay
- ChEMBL_1795838 (CHEMBL4267955) Inhibition of HIV1 RES056 reverse transcriptase K103N/Y181C double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect
- ChEMBL_1899209 (CHEMBL4401324) Inhibition of HIV1 reverse transcriptase polymerase using deoxynucleotide triphosphates and 18 nucleotide DNA primer annealed to 100 nucleotide DNA template after 30 mins
- ChEMBL_1925208 (CHEMBL4428280) Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrate
- ChEMBL_2081890 (CHEMBL4737681) Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into wild type RT measured after 1 hr by ELISA
- ChEMBL_2201723 (CHEMBL5114431) Inhibition of HIV-1 reverse transcriptase in virus infected human C8166 cells assessed as reduction in virus-induced cytopathic effect by MTT assay
- ChEMBL_2323751 Inhibition of HIV-1 reverse transcriptase assessed as assessed as reduction of biotin-dUTP incorporation into protein incubated for 1 hrs by ELISA analysis
- ChEMBL_581398 (CHEMBL1053305) Inhibition of HIV1 recombinant RNA-dependent DNA polymerase activity of reverse transcriptase assessed as incorporation of radioactive dTTP into poly(rA)/oligo(dT)
- ChEMBL_722004 (CHEMBL1675619) Inhibition of RNA-dependent DNA polymerase activity of wild-type Human immunodeficiency virus 1 subtype B reverse transcriptase by filter-based filtration assay
- ChEMBL_79631 (CHEMBL695505) Cross Resistance (antiviral activity)of the compound with 4xAZT/Y181C (Non nucleoside reverse transcriptase inhibitor) resistant HIV isolate from cytopathic cell killing assay
- ChEMBL_858888 (CHEMBL2167934) Inhibition of HIV1 reverse transcriptase L100I mutant RNA-dependent DNA polymerase activity using poly(rA)/oligo(dT)10:1 and [3H]-dTTP substrate
- ChEMBL_858889 (CHEMBL2168109) Inhibition of HIV1 reverse transcriptase K103N mutant RNA-dependent DNA polymerase activity using poly(rA)/oligo(dT)10:1 and [3H]-dTTP substrate
- ChEMBL_858890 (CHEMBL2168110) Inhibition of wild type HIV1 reverse transcriptase RNA-dependent DNA polymerase activity using poly(rA)/oligo(dT)10:1 and [3H]-dTTP substrate
- ChEMBL_884996 (CHEMBL2211256) Inhibition of HIV1 reverse transcriptase assessed as biotin-dUTP incorporation into enzyme using poly(rC)-oligo(dG) as template primer by colorimetric analysis
- HIV RT Assay The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.