Affinity DataIC50: 1.10nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 2nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.49nMAssay Description:Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
TargetGuanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2(Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 4nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMT: 25°CAssay Description:The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Partial displacement of [3H]LY354740 from recombinant rat mGluR2More data for this Ligand-Target Pair