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Found 10 of ec50 for monomerid = 50105085
TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  21nMAssay Description:The EC50 and Imax for μ opioid receptors was determined using a [35S]GTPγS binding assay. This assay measures the functional properties of ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  25.1nMpH: 7.4 T: 2°CAssay Description:Test compound and/or vehicle was preincubated with the cell membranes and 3 uM GDP in modified HEPES buffer (pH 7.4) for 20 minutes, followed by addi...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  34nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  34nMAssay Description:The Ki (binding affinity) for opioid receptors was determined using a competitive displacement assay as previously described in Neumeyer (Journal of ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetMu-type opioid receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  46nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  56nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50105085(17-cyclobutylmethyl-4,5alpha-epoxymorphinan-3,6alp...)
Affinity DataEC50:  250nMAssay Description:Agonist activity at human KOPR expressed in U2OS cells assessed as beta-arrestin2 recruitment after 90 mins by DiscoveRx PathHunter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank