Affinity DataIC50: 10nMAssay Description:Inhibition of pure human thymidyllate synthase from extract of Manca human lymphoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against thymidylate synthase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of Escherichia coli thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 microMMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of thymidyllate synthase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Evaluated for the inhibition of thymidylate synthase in L. caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against dihydrofolate reductase derived from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Evaluated for the inhibition of thymidylate synthase in intact L1210 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against thymidylate Synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibitory activity against thymidylate Synthase from human recombinant sourcesMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:The compound was not tested for inhibition of L1210 Thymidylate synthase due to insolubilityMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against Lactobacillus casei Thymidylate synthase (TS).More data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibitory concentration against Escherichia coli Thymidylate synthase (TS).More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against recombinant human (rh) Thymidylate synthase (TS)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of Toxoplasma gondii DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Concentration required for 50% inhibition against dihydrofolate reductase of S. faeciumMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibitory concentration against rat Thymidylate synthase (TS)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University
Curated by ChEMBL
Duquesne University
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of Toxoplasma gondii thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of dihydrofolate reductase in Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Evaluated for the inhibition of dihydrofolate reductase in L. caseiMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibitory activity against dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:The compound was evaluated in vitro for inhibition of purified L1210 dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:Tested for 50% inhibition of WI-L2 Dihydrofolate reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibitory activity against thymidylate synthase in the intact L1210 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+3nMAssay Description:Evaluated for the inhibition of thymidylate synthesis in intact L1210 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Concentration required for 50% inhibition against dihydrofolate reductase of S. faeciumMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against the thymidylate synthase in the Permeabilized L1210 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of Escherichia coli DHFRMore data for this Ligand-Target Pair