BindingDB PrimarySearch

Found 14 of ic50 for monomerid = 50328584

Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 0.290nMAssay Description:Inhibition of human mTOR complex 1 after 30 mins by FRET assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 2nMAssay Description:Inhibition of mTOR in p53-deficient MEF assessed as phosphorylation of S6K1 at Thr389 by immunoblottingMore data for this Ligand-Target Pair

PDB Reactome pathway
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Target of rapamycin complex subunit LST8(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 2nMAssay Description:Inhibition of N-terminally FLAG-tagged mTORC1 (unknown origin) expressed in HEK293T cells using S6K1 or Akt1 as substrate after 20 mins by immunoblot...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 4.30nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 6.30nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Target of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 10nMAssay Description:Inhibition of N-terminally FLAG-tagged mTORC2 (unknown origin) expressed in human HeLa cells using S6K1 or Akt1 as substrate after 20 mins by immunob...More data for this Ligand-Target Pair

PDB MMDB KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 171nMAssay Description:Inhibition of P110gammaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 176nMAssay Description:Inhibition of PI3K-C2 alphaMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 250nMAssay Description:Inhibition of P110alpha/p85-alphaMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 533nMAssay Description:Inhibition of human hVPS34More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 549nMAssay Description:Inhibition of PI3K-C2 betaMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 564nMAssay Description:Inhibition of P110delta/p85-alphaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: 6.68E+3nMAssay Description:Inhibition of PI4KbetaMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)

IC50: >1.00E+4nMAssay Description:Inhibition of PI4KalphaMore data for this Ligand-Target Pair

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Filter my 14 hits

Targets 12▿
- Serine/threonine-protein kinase mTOR 3
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Phosphatidylinositol 4-kinase alpha 1
- Target of rapamycin complex 2 subunit MAPKAP1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- DNA-dependent protein kinase catalytic subunit 1
- Target of rapamycin complex subunit LST8 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
Publications 2▿
- J Med Chem 53: 7146-55 (2010) 12
- J Med Chem 61: 4656-4687 (2018) 2
Institutions 2▿
- Dana-Farber Cancer Institute 12
- China Pharmaceutical University 2
Affinity: 0.29 to 1.0E+4 nM▿
- IC50 14
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1