Compile Data Set for Download or QSAR
maximum 50k data
Found 17 of ic50 for monomerid = 50330261
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CDK4/cyclin D1 expressed in baculovirus infected Sf21 cells after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50:  324nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50:  365nMAssay Description:Inhibition of CDK4 in human Jeko1 cells assessed as phosphorylated pRb at Ser780 level after 2 hrs by ELISA relative to total pRb levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50:  5.27E+3nMAssay Description:Inhibition of human CDK2/cyclin A after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PKBalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-METMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50330261(4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of human CDK1/cyclin B after 2 hrs by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed