Compile Data Set for Download or QSAR
maximum 50k data
Found 778 of ic50 for UniProtKB: O60885
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575844(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl-4-...)
Affinity DataIC50:  0.300nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575868(4-((6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-methy...)
Affinity DataIC50:  0.340nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575845((S)-2-(6-(3,5-dimethylisoxazol-4-yl)-4-((3-fluorop...)
Affinity DataIC50:  0.350nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575867((S)-2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-4-((...)
Affinity DataIC50:  0.400nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575781((S)-2-(6-(3,5-dimethylisoxazol-4-yl)-1-methyl-4-(p...)
Affinity DataIC50:  0.480nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575853((S)-2-(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-me...)
Affinity DataIC50:  0.490nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575852(2-(4-((3-Fluoropyridin-2-yl)(tetrahydro-2H-pyran-4...)
Affinity DataIC50:  0.540nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575846(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-N,1-dimethy...)
Affinity DataIC50:  0.550nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575849(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  0.570nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575851(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  0.590nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575869(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-N,N,1-trime...)
Affinity DataIC50:  0.610nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575847(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  0.660nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575856(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-4-((3-me...)
Affinity DataIC50:  0.680nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575850(3-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  0.790nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575854(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-4-((3-fl...)
Affinity DataIC50:  0.880nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575855((S)-2-(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-4-((...)
Affinity DataIC50:  0.970nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575859(2-(6-(3,5-dimethylisoxazol-4-yl)-1-methyl-4-((tetr...)
Affinity DataIC50:  0.990nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575848(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  1.10nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575863(2-(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  1.30nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575865(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  1.60nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575860((S)—N-(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)...)
Affinity DataIC50:  1.90nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249313(US9458145, 1020-289)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM223492(US10407441, Compound JQ8 | US10925881, Name (S)-JQ...)
Affinity DataIC50:  2.19nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575861(2-(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl...)
Affinity DataIC50:  2.20nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM223493(US10407441, Compound JQ13 | US10925881, Name (S)-J...)
Affinity DataIC50:  2.49nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575862((R)-2-(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-4-((...)
Affinity DataIC50:  3nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM223491(US10407441, Compound JQ6 | US10925881, Name (S)-JQ...)
Affinity DataIC50:  3.48nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249309(US10017501, Compound 1020-114 | US9458145, 1020-11...)
Affinity DataIC50:  3.80nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249305(US10017501, Compound 1020-103 | US9458145, 1020-10...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575864((R)-2-(6-(3,5-dimethylisoxazol-4-yl)-4-((3-fluorop...)
Affinity DataIC50:  4.60nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575866(6-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-1-methyl-3-...)
Affinity DataIC50:  4.67nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249312(US10017501, Compound 1020-257 | US9458145, 1020-25...)
Affinity DataIC50:  4.70nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249314(US10017501, Compound 1020-298 | US9458145, 1020-29...)
Affinity DataIC50:  5.40nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249311(US10017501, Compound 1020-239 | US9458145, 1020-23...)
Affinity DataIC50:  5.90nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249306(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Affinity DataIC50:  7.20nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249307(US10017501, Compound 1020-112 | US9458145, 1020-11...)
Affinity DataIC50:  10.4nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249308(US10017501, Compound 1020-113 | US9458145, 1020-11...)
Affinity DataIC50:  10.7nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249310(US10017501, Compound 1020-224 | US9458145, 1020-22...)
Affinity DataIC50:  10.8nMpH: 7.5 T: 2°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575857(2-(6-(3,5-dimethylisoxazol-4-yl)-1-methyl-4-((3-me...)
Affinity DataIC50:  12nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249284(US10017501, Compound 1020-72 | US9458145, 1020-72)
Affinity DataIC50:  12.3nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249297(US10017501, Compound 1020-102 | US9458145, 1020-10...)
Affinity DataIC50:  14.3nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249277(US10017501, Compound 1020-18 | US9458145, 1020-18)
Affinity DataIC50:  14.4nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249292(US10017501, Compound 1020-88 | US9458145, 1020-88)
Affinity DataIC50:  15.9nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575858(2-(6-(1,4-Dimethyl-1H-1,2,3-triazol-5-yl)-4-(1-(4-...)
Affinity DataIC50:  17nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by EchoŽ 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  18nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249279(US10017501, Compound 1020-28 | US9458145, 1020-28)
Affinity DataIC50:  18.1nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249285(US10017501, Compound 1020-74 | US9458145, 1020-74)
Affinity DataIC50:  18.9nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  19nMAssay Description:1. Add 20 μl of the diluted compound to each well of the 384-well opti plate2. Tap the plate gently3. Add 10 μl of the enzyme to each well ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249281(US10017501, Compound 1020-44 | US9458145, 1020-44)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM249283(US10017501, Compound 1020-57 | US9458145, 1020-57)
Affinity DataIC50:  22.6nMpH: 7.5 T: 2°CAssay Description:Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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